Cholesterol metabolism in immune cells: From mechanisms to therapeutic opportunities [0.03%]
胆固醇代谢的免疫细胞：从机制到治疗机遇
Mingyang Yin,Tao Liang,Yumeng Zhang et al.
Mingyang Yin et al.
All immune cells engage in cholesterol metabolism, which generates a spectrum of bioactive metabolites that mainly include cholesterol itself, its biosynthetic intermediates, and oxidized or sulfated derivatives. These metabolites regulate ...
Théo Bouloudani,Catherine Sautès-Fridman
Théo Bouloudani
The presence of tertiary lymphoid structures (TLSs) associates with improved anti-tumor immunity, and as such, understanding why some tumors develop TLSs is of prime interest. In the current issue of Cancer Cell, Kirschstein et al. demonstr...
Spyridon Makris,Sophie E Acton
Spyridon Makris
Fibroblasts are highly attuned for immune crosstalk within lymphoid tissues. In this issue of Immunity, Alouche et al. provide insight into how fibroblast immunoregulatory phenotypes are acquired and maintained, revealing that Ccl19hi fibro...
Guillem Montamat-Garcia,Claudia Mauri
Guillem Montamat-Garcia
Systemic lupus erythematosus is characterized by autoantibodies against nuclear antigens. In this issue of Immunity, Al Souz et al. report that kidney damage in lupus nephritis is sustained by stem-like CD8+ T cells that migrate from lympho...
Guardian of two galaxies: Senescence-associated immune cells control disease tolerance and aging [0.03%]
二星系守护者：衰老相关免疫细胞控制疾病耐受性和衰老
Wolfgang Vivas,Sebastian Weis
Wolfgang Vivas
Preservation of host fitness is a common feature of longevity and immunity to infection. In this issue of Immunity, Triana-Martinez et al. reveal that p16High senescence-associated immune cells promote disease tolerance and healthy aging. M...
Eunyoung Kim,Xinzhu Yu
Eunyoung Kim
Altered astrocyte-microglia interactions have been implicated in the pathogenesis of Alzheimer's disease, but the underpinning mechanisms remain unclear. Zhang and colleagues show that astrocytic PAD2-mediated citrullination of vimentin act...
Communicating science [0.03%]
科技的沟通交流
Shruti Naik,Josep Tabernero,Fabienne Mackay et al.
Shruti Naik et al.
Research that is done but never shared cannot make an impact. Science communication has many forms and audiences, from research colleagues to the general public. Here, investigators discuss the importance of engaging in the dissemination of...
Activating an interleukin 4-FLT3-STAT6 axis in multipotent progenitors restores lymphopoiesis in inflammation and aging [0.03%]
激活多能祖细胞中的白细胞介素4-FLT3- STAT6轴可在炎症和衰老期间恢复淋巴细胞生成
Jingfei Yao,Yuting Wang,Yi Zhang
Jingfei Yao
Chronic inflammation and aging skew hematopoiesis toward myelopoiesis at the expense of lymphoid output. We screened type 2 and anti-inflammatory cytokines to identify extrinsic signals capable of restoring lymphoid lineage commitment in he...
A longitudinal atlas of human psoriatic skin reveals the mechanisms of anti-IL-23 therapy in disrupting the type 17 inflammatory circuit [0.03%]
人皮肤银屑病纵向图谱揭示抗IL-23疗法破坏Ⅰ型先天性炎症回路的机制
Rundong Jiang,Andrew Blauvelt,Linyu Shi et al.
Rundong Jiang et al.
Biologic therapies targeting the IL-23/IL-17 axis have transformed the treatment of psoriasis and show lasting efficacy after treatment cessation. To investigate the immune mechanisms behind these biologics, we performed single-cell RNA seq...
Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells [0.03%]
卵巢癌肿瘤引流淋巴结缺乏生发中心但富集了与瘤内B细胞克隆相关的抗肿瘤记忆B细胞
Nachum Nathan,Philipp Paparoditis,Avital Sarusi-Portuguez et al.
Nachum Nathan et al.
The presence of B cells within high-grade serous ovarian cancer (HGSOC) tumors associates with favorable prognoses. We examined the contribution of tumor-draining lymph nodes (TDLNs) to the anti-tumor B cell response. Patient-derived TDLNs ...