Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity [0.03%]
原位Pfs230-Pfs48/45复合物与六种阻断疟疾传播抗体的冷冻电镜结构揭示了其作用机制
Ezra T Bekkering,Randy Yoo,Sophia Hailemariam et al.
Ezra T Bekkering et al.
The Pfs230:Pfs48/45 complex forms the basis for leading malaria transmission-blocking vaccine candidates, yet little is known about its molecular assembly. Here, we used cryo-electron microscopy to elucidate the structure of the endogenous ...
Obesity, diabetes, and inflammation: Pathophysiology and clinical implications [0.03%]
肥胖、糖尿病和炎症：病理生理学及临床意义
Marc Y Donath,Daniel J Drucker
Marc Y Donath
Obesity and its related disorders, including type 2 diabetes and liver, kidney, and cardiovascular diseases, are now recognized as chronic inflammatory conditions. Here, we review the mechanisms underlying inflammation in these settings and...
Peter Libby,Oliver Soehnlein
Peter Libby
Inflammatory pathways operate at all stages of atherosclerosis. These processes are driven by risk factors and other stimuli that can spark inflammation by eliciting misdirected responses of intrinsic vascular cells and leukocytes, culminat...
Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis [0.03%]
NOTCH3通过破坏调节性T细胞在多发性硬化中驱动自身免疫性神经炎症
Mehdi Benamar,Paola Contini,Klaus Schmitz-Abe et al.
Mehdi Benamar et al.
The immune regulatory defects that promote neuroinflammation in multiple sclerosis (MS) remain unclear. We show that a specific regulatory T (Treg) cell subpopulation expressing Notch3 was increased in individuals with MS and in mice with e...
The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells [0.03%]
转录抑制因子BLIMP1制约CD8⁺T细胞记忆分化命运
Maegan K Murphy,Matthew McCullen,Joshua L Deffenbaugh et al.
Maegan K Murphy et al.
During differentiation of CD8+ T cells, the transcription factors TCF-1 and Blimp1 control progenitor and terminally differentiated states, respectively. Here, we examined the hierarchy and functional consequences of cross-regulation betwee...
Eomesodermin+ CD4+ T cells are critical for curative immunotherapy outcomes [0.03%]
Eomesodermin+ CD4+ T细胞对治愈性免疫疗法效果至关重要
Ping Zhang,Françoise Haeseleer,Olivia G Waltner et al.
Ping Zhang et al.
Interleukin 10 (IL-10)-producing CD4+ type-1 regulatory T cells (Tr1) promote immune tolerance during chronic infection, autoimmunity, and transplantation. However, specific Eomesodermin (Eomes)-dependent stages of Tr1 differentiation and f...
S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis [0.03%]
金黄色葡萄球菌参与皮肤抗原致敏引起的basophil和白细胞介素4依赖性食物过敏反应增强现象
Mrinmoy Das,Mohammed Alasharee,Brian Woods et al.
Mrinmoy Das et al.
The mechanism of the association of S. aureus skin colonization with food allergy in atopic dermatitis (AD) is unknown. Interleukin-4 (IL-4) plays an important role in food allergy. We found elevated serum IL-4 concentrations in AD patients...
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4 [0.03%]
瘤内低氧通过慢性激活整合应激反应转录因子ATF4促进CD8+T细胞功能障碍
Coral Del Mar Alicea Pauneto,Brian P Riesenberg,Evelyn J Gandy et al.
Coral Del Mar Alicea Pauneto et al.
Metabolic stress in the tumor microenvironment (TME) promotes T cell dysfunction and immune checkpoint inhibitor (ICI) resistance. We examined the contribution of activating transcription factor 4 (ATF4), the central node of the integrated ...
Control of myeloid lineage fidelity and response to stimuli by ISWI-enforced nucleosome phasing [0.03%]
ISWI介导的核小体定位确保髓系细胞谱系稳定性和信号响应性
Sara Polletti,Júlia Melià-Alomà,Francesco Pileri et al.
Sara Polletti et al.
The interplay between chromatin remodelers and pioneer transcription factors (TFs) regulates cis-regulatory element accessibility to maintain cell identity and transcriptional fidelity. We investigated the impact of imitation of switch (ISW...
Stephanie C Eisenbarth,Facundo Batista,Jason Cyster et al.
Stephanie C Eisenbarth et al.
In the twenty years since extrafollicular B cell responses were originally described, much has been learned about B cell biology. With this progress, the term "extrafollicular" has expanded beyond its initial use to describe a variety of B ...