A longitudinal study of children identifies antibody Fc-mediated functions and antigen targets of immunity to Plasmodium vivax malaria [0.03%]
一项针对儿童的纵向研究识别出抗疟原虫疟疾的免疫抗体Fc介导的功能及抗原目标
D Herbert Opi,Rhea J Longley,Eizo Takashima et al.
D Herbert Opi et al.
Plasmodium vivax is the most widespread cause of malaria with a high burden of disease. Progress in reducing the global malaria burden has stalled with no vaccines available partly due to a limited knowledge of targets and mechanisms of pro...
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes [0.03%]
晚近进入生发中心的B淋巴细胞优先分化为识别亚显性表位的记忆细胞
Pengcheng Zhou,Harald Hartweger,Andrew J MacLean et al.
Pengcheng Zhou et al.
Germinal center (GC) responses are initially seeded by founder B cells and subsequently diversified by continual entry of naive B cells that compete for antigen and T cell help. Here, we examined the contribution of these later-arriving inv...
Xiaoying Chen,David M Holtzman,Marco Colonna
Xiaoying Chen
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to cognitive decline, dementia, and ultimately death. Recent anatomical and functional discoveries of neuroimmune interactions during the development and progre...
MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species [0.03%]
MafB是一个保守的转录调节因子，在组织和物种中调控巨噬细胞发育和功能身份
Domien Vanneste,Wen Peng,Zhuangzhuang Liu et al.
Domien Vanneste et al.
Homeostatic resident tissue macrophages (RTMs) not only exhibit diversity across tissues but also share common features that are driven by conserved transcriptional programs. While the transcription factor MafB is highly expressed in macrop...
Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer [0.03%]
氧化应激诱导的端粒不稳定性驱动癌症中的T细胞功能障碍
Dayana B Rivadeneira,Sanjana Thosar,Kevin Quann et al.
Dayana B Rivadeneira et al.
Published Erratum
Immunity. 2026 Feb 26:S1074-7613(26)00085-3. DOI:10.1016/j.immuni.2026.02.015 2026
HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV-vectored immunotherapy in humanized mice [0.03%]
人源化小鼠中的HIV广谱中和抗体逃逸动力学决定了腺相关病毒载体免疫治疗的效果
Nicolas M S Galvez,Adam D Nitido,Seo Bin Yoo et al.
Nicolas M S Galvez et al.
Broadly neutralizing antibodies (bNAbs) have shown promise for the prevention and treatment of HIV. Potency and breadth measured in vitro are often used as predictors of clinical potential; however, human studies demonstrate that the clinic...
Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection [0.03%]
感觉神经元产生的物质P和TAFA4在病毒感染过程中促进疾病耐受性
Anais Roger,Tiphaine Fohrer,Ugo Mardelle et al.
Anais Roger et al.
Host resistance to infection relies on coordinated interactions between the immune and nervous systems. However, the molecular mechanisms underlying this cross-regulation remain unclear, particularly during viral infections. We have shown t...
Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection [0.03%]
干细胞样上皮内γδT细胞分化是宿主抵抗感染的必需条件
Shiyuan Xie,Qi Xing,Qian Zhang et al.
Shiyuan Xie et al.
TCRγδ+ intraepithelial lymphocytes (γδIELs) are crucial for maintaining intestinal homeostasis, yet their functional regulation remains incompletely understood. Here, we demonstrated two distinct γδIEL subsets: CD160+TCF1+BCL6+ stem-l...
Antibody-mediated feedback modulates interclonal competition in the germinal center [0.03%]
抗体介导的反馈调节生发中心间的克隆竞争
Alexandru Barbulescu,Jana Bilanovic,Tom Langelaar et al.
Alexandru Barbulescu et al.
Antibodies generated by prior immune responses regulate B cell activation and germinal center (GC) access upon recall immunization. Here, we examined how antibodies produced by an ongoing immune response influence the outcomes of contempora...
Polystyrene microplastic-induced pathophysiology is driven by disruption of efferocytosis [0.03%]
聚苯乙烯微塑料引起的病理生理学由抑制吞噬作用驱动
Ana C Codo,Jesus E Romero-Pichardo,Zhaoquan Wang et al.
Ana C Codo et al.
Microplastics (MPs), microparticles from plastic degradation, pose a substantial threat to human health. Macrophages, the body's immune sentinels, are unable to break down MPs, suggesting that MP accumulation could impair essential function...