The liver-secreted protein FGL1 restrains a subset of innate-like B cell responses via the receptor TACI [0.03%]
肝分泌蛋白FGL1通过受体TACI限制一类固有样B细胞反应
Tina Tianjiao Su,Jianwei He,Yuge Wang et al.
Tina Tianjiao Su et al.
The liver-secreted protein fibrinogen-like protein 1 (FGL1) is a ligand of the coinhibitory receptor LAG3 on T cells; however, Fgl1-/- mice exhibit autoimmune features distinct from those of Lag3-/- mice. Here, we examined whether FGL1 acts...
Qian Fang,Kai Markus Schneider
Qian Fang
Bile acids have emerged as compartmentalized immunometabolic signals that link host metabolism, microbial ecology, and tumor immunity. Altered bile acid profiles are common across malignancies and are associated with tumor progression, immu...
Environmentally induced cell stiffening shapes metastatic site selection by tuning the immune vulnerability of cancer cells [0.03%]
肿瘤细胞通过调节免疫脆弱性来选择转移部位
Yassmin A Elbanna,Maria Tello-Lafoz,Aliya Holland et al.
Yassmin A Elbanna et al.
Metastatic microenvironments vary widely not only in their biochemical composition but also in their mechanical properties. Here, we examined how the mechanical rigidity of the metastatic niche affects metastases seeding and the local effic...
TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation [0.03%]
初始T调节细胞在外周的分化取决于TCR识别环境或自身抗原的APC类型及特异性
Xinxin Chi,Charlotte H Wang,Yollanda Franco Parisotto et al.
Xinxin Chi et al.
Peripheral differentiation of regulatory T (pTreg) cells promotes immunological tolerance to obligate non-self, such as food or symbiotic microbes. We examined the relative importance of TCR recognition vs. environmental cues, leveraging CR...
Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma [0.03%]
疾病相关小胶质细胞在胶质瘤中采用阶段特异性表型以调节T细胞命运和免疫反应
Jiawen Qian,Chen Wang,Yi Zhang et al.
Jiawen Qian et al.
Malignant gliomas are lethal brain tumors characterized by profound local immunosuppression and a radically remodeled myeloid landscape. Although these tumors mobilize resident microglia and infiltrating monocyte-derived macrophages, the me...
Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING [0.03%]
嘌呤和嘧啶类细菌环二核苷酸逃逸吞噬体并激活固有免疫传感器STING
Stephanie A Ragland,Katherine E Lindblad,Yao Li et al.
Stephanie A Ragland et al.
Toll-like receptors (TLRs) are considered general sensors of bacterial encounters. Here, we examined whether other pattern recognition receptors are commonly activated during bacterial infection. TLR-independent interferon (IFN) responses w...
Autophagy maintains high endothelial venule identity and function during inflammation [0.03%]
自噬在炎症期间维持高内皮微静脉的同一性和功能
Kathryn A Jacobs,Yichao Hua,Apostolos Panagiotis Nikolakopoulos et al.
Kathryn A Jacobs et al.
High endothelial venules (HEVs) play a crucial role in adaptive immune responses in secondary lymphoid organs (SLOs). They are equipped with high amounts of peripheral node addressin (PNAd), harboring carbohydrate structures that serve as L...
The transcription factor BACH1 couples chromatin priming and repression to enable macrophage plasticity and adaptation [0.03%]
转录因子BACH1通过连接染色质预备和抑制来实现巨噬细胞的可塑性和适应性
Petros Tzerpos,Dóra Bojcsuk,Krisztian Bene et al.
Petros Tzerpos et al.
Macrophage activation and tissue adaptation involve precise transcriptional control by lineage-determining transcription factors (LDTFs) and stimulus-dependent TFs. The heme-regulated transcriptional repressor BACH1 clusters with myeloid LD...
Activation of the auricular vagus nerve reflex suppresses airway inflammation [0.03%]
耳迷走神经反射激活可抑制气道炎症反应
Rintaro Shibuya,Nobuya Abe,Keaton Song et al.
Rintaro Shibuya et al.
The vagus nerve regulates inflammation via sensory-motor arcs. While vagal sensory neurons relay signals from within the body (interoception), whether external inputs can regulate visceral neuroimmune responses (exteroception) remains poorl...
Antigen-restricted Candida albicans Th17 cells link oral-gut immunity and adopt pathogenic features during intestinal inflammation [0.03%]
抗原限制的白色念珠菌Candida albicans Th17细胞连接口腔-肠道免疫并在肠炎期间采用致病特征
Gabriela Rios Martini,Philipp Hofmann,Ann-Kristin Kamps et al.
Gabriela Rios Martini et al.
The commensal yeast Candida albicans is a major inducer of human mucosal Th17 cells. How C. albicans drives Th17 cell responses at homeostasis, and whether such responses contribute to inflammatory diseases, remains poorly understood. Here,...