Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation [0.03%]
组蛋白H3变异通过DDM1介导的染色质重塑遗传甲基化模式
Seung Cho Lee,Dexter W Adams,Jonathan J Ipsaro et al.
Seung Cho Lee et al.
Nucleosomes block access to DNA methyltransferase, unless they are remodeled by DECREASE in DNA METHYLATION 1 (DDM1LSH/HELLS), a Snf2-like master regulator of epigenetic inheritance. We show that DDM1 promotes replacement of histone variant...
Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis [0.03%]
调控血细胞生成的偏向分子机制蓝图
Naotaka Tsutsumi,Zahra Masoumi,Sophie C James et al.
Naotaka Tsutsumi et al.
Thrombopoietin (THPO or TPO) is an essential cytokine for hematopoietic stem cell (HSC) maintenance and megakaryocyte differentiation. Here, we report the 3.4 Å resolution cryoelectron microscopy structure of the extracellular TPO-TPO rece...
PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development [0.03%]
PINK1、Keap1和Rtnl1在发育过程中调节内质网的选择性清除作用
Ruoxi Wang,Tina M Fortier,Fei Chai et al.
Ruoxi Wang et al.
Selective clearance of organelles, including endoplasmic reticulum (ER) and mitochondria, by autophagy plays an important role in cell health. Here, we describe a developmentally programmed selective ER clearance by autophagy. We show that ...
Rhythm Shukla,Aaron J Peoples,Kevin C Ludwig et al.
Rhythm Shukla et al.
Antimicrobial resistance is a leading mortality factor worldwide. Here, we report the discovery of clovibactin, an antibiotic isolated from uncultured soil bacteria. Clovibactin efficiently kills drug-resistant Gram-positive bacterial patho...
Brain-wide representations of behavior spanning multiple timescales and states in C. elegans [0.03%]
一种可以在多个时间尺度和状态下表示行为的全脑模型及其在秀丽隐杆线虫中的应用
Adam A Atanas,Jungsoo Kim,Ziyu Wang et al.
Adam A Atanas et al.
Changes in an animal's behavior and internal state are accompanied by widespread changes in activity across its brain. However, how neurons across the brain encode behavior and how this is impacted by state is poorly understood. We recorded...
Fei Tang,Jinhu Li,Lu Qi et al.
Fei Tang et al.
Natural killer (NK) cells play indispensable roles in innate immune responses against tumor progression. To depict their phenotypic and functional diversities in the tumor microenvironment, we perform integrative single-cell RNA sequencing ...
Epigenetic memory of coronavirus infection in innate immune cells and their progenitors [0.03%]
冠状病毒感染在固有免疫细胞及其祖细胞中的表观遗传记忆
Jin-Gyu Cheong,Arjun Ravishankar,Siddhartha Sharma et al.
Jin-Gyu Cheong et al.
Inflammation can trigger lasting phenotypes in immune and non-immune cells. Whether and how human infections and associated inflammation can form innate immune memory in hematopoietic stem and progenitor cells (HSPC) has remained unclear. W...
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin [0.03%]
肿瘤相关巨噬细胞触发肝癌浸润边缘MAIT细胞功能障碍
Benjamin Ruf,Matthias Bruhns,Sepideh Babaei et al.
Benjamin Ruf et al.
Mucosal-associated invariant T (MAIT) cells represent an abundant innate-like T cell subtype in the human liver. MAIT cells are assigned crucial roles in regulating immunity and inflammation, yet their role in liver cancer remains elusive. ...
A conserved family of immune effectors cleaves cellular ATP upon viral infection [0.03%]
一个保守的免疫效应物家族在病毒感染时切割细胞内的ATP
Francois Rousset,Erez Yirmiya,Shahar Nesher et al.
Francois Rousset et al.
During viral infection, cells can deploy immune strategies that deprive viruses of molecules essential for their replication. Here, we report a family of immune effectors in bacteria that, upon phage infection, degrade cellular adenosine tr...
Nicolas C Rivron,Alfonso Martinez Arias,Martin F Pera et al.
Nicolas C Rivron et al.
A human embryo's legal definition and its entitlement to protection vary greatly worldwide. Recently, human pluripotent stem cells have been used to form in vitro models of early embryos that have challenged legal definitions and raised que...