High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases [0.03%]
油酰-ACP水解酶高表达导致危及生命的呼吸系统病毒感染
Xiaoxiao Jia,Jeremy Chase Crawford,Deborah Gebregzabher et al.
Xiaoxiao Jia et al.
Respiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In patients hospitalized with avian A(H7N9) influenza, we investigated early drivers underpinning fatal dise...
Daan J Kloosterman,Johanna Erbani,Menno Boon et al.
Daan J Kloosterman et al.
Tumors growing in metabolically challenged environments, such as glioblastoma in the brain, are particularly reliant on crosstalk with their tumor microenvironment (TME) to satisfy their high energetic needs. To study the intricacies of thi...
Digvijay Singh,Neelesh Soni,Joshua Hutchings et al.
Digvijay Singh et al.
The nuclear pore complex (NPC) is the sole mediator of nucleocytoplasmic transport. Despite great advances in understanding its conserved core architecture, the peripheral regions can exhibit considerable variation within and between specie...
The need to diversify genomic studies: Insights from Andean highlanders and Amazonians [0.03%]
基因组研究多样化的必要性：安第斯高原人和亚马逊人的视角
Isabela Alvim,Carolina Silva-Carvalho,Marla Mendes de Aquino et al.
Isabela Alvim et al.
More globally diverse perspectives are needed in genomic studies and precision medicine practices on non-Europeans. Here, we illustrate this by discussing the distribution of clinically actionable genetic variants involved in drug response ...
Stress-sensitive neural circuits change the gut microbiome via duodenal glands [0.03%]
应激敏感神经环路通过十二指肠腺体改变肠道微生物群
Hao Chang,Matthew H Perkins,Leonardo S Novaes et al.
Hao Chang et al.
Negative psychological states impact immunity by altering the gut microbiome. However, the relationship between brain states and microbiome composition remains unclear. We show that Brunner's glands in the duodenum couple stress-sensitive b...
Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity [0.03%]
LAG-3和PD-1阻滞使CD8+t细胞中的细胞毒性基因模块和耗竭基因模块共表达以促进抗肿瘤免疫反应
Anthony R Cillo,Carly Cardello,Feng Shan et al.
Anthony R Cillo et al.
Relatlimab (rela; anti-LAG-3) plus nivolumab (nivo; anti-PD-1) is safe and effective for treatment of advanced melanoma. We designed a trial (NCT03743766) where advanced melanoma patients received rela, nivo, or rela+nivo to interrogate the...
Clinical Trial
Cell. 2024 Aug 8;187(16):4373-4388.e15. DOI:10.1016/j.cell.2024.06.036 2024
LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity [0.03%]
LAG-3和PD-1在CD8⁺T细胞上的协同作用促进耗竭并妨碍IFN-γ自分泌依赖性抗肿瘤免疫反应
Lawrence P Andrews,Samuel C Butler,Jian Cui et al.
Lawrence P Andrews et al.
Overcoming immune-mediated resistance to PD-1 blockade remains a major clinical challenge. Enhanced efficacy has been demonstrated in melanoma patients with combined nivolumab (anti-PD-1) and relatlimab (anti-LAG-3) treatment, the first in ...
LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity [0.03%]
LAG-3维持TOX表达，并通过调节CD94/NKG2-Qa-1轴调控耗竭性CD8+T细胞NK受体的表达及其细胞毒作用
Shin Foong Ngiow,Sasikanth Manne,Yinghui Jane Huang et al.
Shin Foong Ngiow et al.
Exhausted CD8 T (Tex) cells in chronic viral infection and cancer have sustained co-expression of inhibitory receptors (IRs). Tex cells can be reinvigorated by blocking IRs, such as PD-1, but synergistic reinvigoration and enhanced disease ...
Guidelines for minimal information on cellular senescence experimentation in vivo [0.03%]
有关体内细胞衰老实验的最少信息标准指南
Mikolaj Ogrodnik,Juan Carlos Acosta,Peter D Adams et al.
Mikolaj Ogrodnik et al.
Cellular senescence is a cell fate triggered in response to stress and is characterized by stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging from tissue repair to chronic disease. The development ...
Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry [0.03%]
窥探秘密：原子水平解析HKU1病毒进入宿主细胞过程中sialoglycan与TMPRSS2的相互作用机制
Ruth J Parsons,Priyamvada Acharya
Ruth J Parsons
The pre-fusion coronavirus HKU1 spike binds host sialoglycans and proteinaceous receptor TMPRSS2 for cell entry. In this issue of Cell, three papers by Fernández et al., McCallum et al., and Wang et al. provide structural information on HK...