Ineffective control of Epstein-Barr-virus-induced autoimmunity increases the risk for multiple sclerosis [0.03%]
EB病毒诱导的自身免疫控制不力增加患多发性硬化症的风险
Hannes Vietzen,Sarah M Berger,Laura M Kühner et al.
Hannes Vietzen et al.
Multiple sclerosis (MS) is a demyelinating disease of the CNS. Epstein-Barr virus (EBV) contributes to the MS pathogenesis because high levels of EBV EBNA386-405-specific antibodies cross react with the CNS-derived GlialCAM370-389. However,...
APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread [0.03%]
APOE3CH改变小胶质细胞反应并抑制Aβ诱导的tau蛋白种子形成和扩散
Yun Chen,Sihui Song,Samira Parhizkar et al.
Yun Chen et al.
A recent case report described an individual who was a homozygous carrier of the APOE3 Christchurch (APOE3ch) mutation and resistant to autosomal dominant Alzheimer's Disease (AD) caused by a PSEN1-E280A mutation. Whether APOE3ch contribute...
Circuit mechanism for suppression of frontal cortical ignition during NREM sleep [0.03%]
非快速眼动睡眠期间抑制前皮层点燃的电路机制
Bing Li,Chenyan Ma,Yun-An Huang et al.
Bing Li et al.
Conscious perception is greatly diminished during sleep, but the underlying circuit mechanism is poorly understood. We show that cortical ignition-a brain process shown to be associated with conscious awareness in humans and non-human prima...
Raphael Blain,Gérard Couly,Eimad Shotar et al.
Raphael Blain et al.
The evolution and development of the head have long captivated researchers due to the crucial role of the head as the gateway for sensory stimuli and the intricate structural complexity of the head. Although significant progress has been ma...
Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy [0.03%]
中期至晚期妊娠及糖尿病妊娠胎儿代谢图谱
Cesar A Perez-Ramirez,Haruko Nakano,Richard C Law et al.
Cesar A Perez-Ramirez et al.
Mounting evidence suggests metabolism instructs stem cell fate decisions. However, how fetal metabolism changes during development and how altered maternal metabolism shapes fetal metabolism remain unexplored. We present a descriptive atlas...
Mapping the transcriptome: Realizing the full potential of spatial data analysis [0.03%]
转录组定位：实现空间数据分析的全部潜力
Eleftherios Zormpas,Rachel Queen,Alexis Comber et al.
Eleftherios Zormpas et al.
RNA sequencing in situ allows for whole-transcriptome characterization at high resolution, while retaining spatial information. These data present an analytical challenge for bioinformatics-how to leverage spatial information effectively? P...
Benjamin Kleaveland
Benjamin Kleaveland
MicroRNAs (miRNAs) guide Argonaute (AGO) proteins to bind and repress target RNAs. However, some unusual targets trigger destruction of the miRNA, a phenomenon known as target-directed miRNA degradation (TDMD). This Snapshot depicts our cur...
Systematic identification and characterization of genes in the regulation and biogenesis of photosynthetic machinery [0.03%]
光合装置调节和生物发生的基因的系统鉴定与表征
Moshe Kafri,Weronika Patena,Lance Martin et al.
Moshe Kafri et al.
Photosynthesis is central to food production and the Earth's biogeochemistry, yet the molecular basis for its regulation remains poorly understood. Here, using high-throughput genetics in the model eukaryotic alga Chlamydomonas reinhardtii,...
Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors [0.03%]
分子构图揭示散发性结直肠肿瘤的进化和微环境动态变化
Cody N Heiser,Alan J Simmons,Frank Revetta et al.
Cody N Heiser et al.
Colorectal cancer exhibits dynamic cellular and genetic heterogeneity during progression from precursor lesions toward malignancy. Analysis of spatial multi-omic data from 31 human colorectal specimens enabled phylogeographic mapping of tum...
Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses [0.03%]
基于trellis树的分析揭示了基质对患者衍生器官样药物反应的调节作用
María Ramos Zapatero,Alexander Tong,James W Opzoomer et al.
María Ramos Zapatero et al.
Patient-derived organoids (PDOs) can model personalized therapy responses; however, current screening technologies cannot reveal drug response mechanisms or how tumor microenvironment cells alter therapeutic performance. To address this, we...