From the operating table to global science: How a near-death experience sparked my passion for life [0.03%]
从手术台到全球科学：一次濒死经历如何点燃我对生活的热情
Kevin Christopher Brown Jr
Kevin Christopher Brown Jr
Kevin Christopher Brown Jr. is a winner of the fourth annual Rising Black Scientists Awards for a scholar in the life and health sciences. We asked emerging Black scientists to tell us about their scientific vision and goals, experiences th...
Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer [0.03%]
化疗难治性高级别浆液性卵巢癌的蛋白质基因组分析
Shrabanti Chowdhury,Jacob J Kennedy,Richard G Ivey et al.
Shrabanti Chowdhury et al.
Published Erratum
Cell. 2024 Feb 15;187(4):1016. DOI:10.1016/j.cell.2024.01.016 2024
GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis [0.03%]
GSDMB在IBD中增加并独立于细胞焦亡调节上皮修复/修补功能
Nitish Rana,Giuseppe Privitera,Hannah C Kondolf et al.
Nitish Rana et al.
Published Erratum
Cell. 2024 Feb 15;187(4):1011-1015. DOI:10.1016/j.cell.2024.01.010 2024
Francesca Petralia,Weiping Ma,Tomer M Yaron et al.
Francesca Petralia et al.
Despite the successes of immunotherapy in cancer treatment over recent decades, less than
Hugo Schweke,Martin Pacesa,Tal Levin et al.
Hugo Schweke et al.
Protein structures are essential to understanding cellular processes in molecular detail. While advances in artificial intelligence revealed the tertiary structure of proteins at scale, their quaternary structure remains mostly unknown. We ...
The cycling and aging mouse female reproductive tract at single-cell resolution [0.03%]
单细胞分辨率下的年轻和年老小鼠雌性生殖系统
Ivana Winkler,Alexander Tolkachov,Fritjof Lammers et al.
Ivana Winkler et al.
The female reproductive tract (FRT) undergoes extensive remodeling during reproductive cycling. This recurrent remodeling and how it shapes organ-specific aging remains poorly explored. Using single-cell and spatial transcriptomics, we syst...
PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends [0.03%]
PARP1-DNA共浓缩驱动DNA修复位点组装以防止断端DNA分离
Nagaraja Chappidi,Thomas Quail,Simon Doll et al.
Nagaraja Chappidi et al.
DNA double-strand breaks (DSBs) are repaired at DSB sites. How DSB sites assemble and how broken DNA is prevented from separating is not understood. Here we uncover that the synapsis of broken DNA is mediated by the DSB sensor protein poly(...
A synthetic differentiation circuit in Escherichia coli for suppressing mutant takeover [0.03%]
大肠杆菌中的一个合成分化电路可用于抑制突变体接管
David S Glass,Anat Bren,Elizabeth Vaisbourd et al.
David S Glass et al.
Differentiation is crucial for multicellularity. However, it is inherently susceptible to mutant cells that fail to differentiate. These mutants outcompete normal cells by excessive self-renewal. It remains unclear what mechanisms can resis...
Microglia maintain structural integrity during fetal brain morphogenesis [0.03%]
小胶质细胞维持胎儿大脑形态发生过程中的结构完整性
Akindé René Lawrence,Alice Canzi,Cécile Bridlance et al.
Akindé René Lawrence et al.
Microglia (MG), the brain-resident macrophages, play major roles in health and disease via a diversity of cellular states. While embryonic MG display a large heterogeneity of cellular distribution and transcriptomic states, their functions ...
Dainan Yu,Haifeng Wan,Chao Tong et al.
Dainan Yu et al.
Pregnancy induces dramatic metabolic changes in females; yet, the intricacies of this metabolic reprogramming remain poorly understood, especially in primates. Using cynomolgus monkeys, we constructed a comprehensive multi-tissue metabolome...