Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a [0.03%]
在使用panobinostat和干扰素-α2a治疗过程中HIV-1前病毒的选择性表观遗传特权现象
Marie Armani-Tourret,Ce Gao,Ciputra Adijaya Hartana et al.
Marie Armani-Tourret et al.
CD4+ T cells with latent HIV-1 infection persist despite treatment with antiretroviral agents and represent the main barrier to a cure of HIV-1 infection. Pharmacological disruption of viral latency may expose HIV-1-infected cells to host i...
Randomized Controlled Trial
Cell. 2024 Feb 29;187(5):1238-1254.e14. DOI:10.1016/j.cell.2024.01.037 2024
The genetic changes that shaped Neandertals, Denisovans, and modern humans [0.03%]
塑造尼安德特人、丹尼索瓦人和现代人类的遗传变化
Hugo Zeberg,Mattias Jakobsson,Svante Pääbo
Hugo Zeberg
Modern human ancestors diverged from the ancestors of Neandertals and Denisovans about 600,000 years ago. Until about 40,000 years ago, these three groups existed in parallel, occasionally met, and exchanged genes. A critical question is wh...
Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis [0.03%]
具有两个多不饱和脂肪酰尾的磷脂促进铁死亡
Baiyu Qiu,Fereshteh Zandkarimi,Carla T Bezjian et al.
Baiyu Qiu et al.
Phospholipids containing a single polyunsaturated fatty acyl tail (PL-PUFA1s) are considered the driving force behind ferroptosis, whereas phospholipids with diacyl-PUFA tails (PL-PUFA2s) have been rarely characterized. Dietary lipids modul...
High fat intake sustains sorbitol intolerance after antibiotic-mediated Clostridia depletion from the gut microbiota [0.03%]
高脂肪摄入在肠道微生物群的梭状芽胞杆菌经抗生素处理减少后维持了山梨醇不耐受持续存在
Jee-Yon Lee,Connor R Tiffany,Scott P Mahan et al.
Jee-Yon Lee et al.
Carbohydrate intolerance, commonly linked to the consumption of lactose, fructose, or sorbitol, affects up to 30% of the population in high-income countries. Although sorbitol intolerance is attributed to malabsorption, the underlying mecha...
A multivalent mRNA monkeypox virus vaccine (BNT166) protects mice and macaques from orthopoxvirus disease [0.03%]
多价mRNA猴痘病毒疫苗（BNT166）可保护小鼠和猕猴免受正痘病毒感染
Adam Zuiani,Charles L Dulberger,Nilushi S De Silva et al.
Adam Zuiani et al.
In response to the 2022 outbreak of mpox driven by unprecedented human-to-human monkeypox virus (MPXV) transmission, we designed BNT166, aiming to create a highly immunogenic, safe, accessible, and scalable next-generation vaccine against M...
A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression [0.03%]
通过逆转座子-RNA调控髓鞘基因表达与有脊椎动物髓鞘形成的逆转病毒联系
Tanay Ghosh,Rafael G Almeida,Chao Zhao et al.
Tanay Ghosh et al.
Myelin, the insulating sheath that surrounds neuronal axons, is produced by oligodendrocytes in the central nervous system (CNS). This evolutionary innovation, which first appears in jawed vertebrates, enabled rapid transmission of nerve im...
Lisa F P Ng,Laurent Rénia
Lisa F P Ng
Although Chikungunya fever does not a have a high fatality rate (
Resilient wings, tangible impact: My journey from chrysalis to changemaker in STEM [0.03%]
坚韧的翅膀，实际的影响：我从蛹到STEM变革者的旅程
Jaye Antoinette Wilson
Jaye Antoinette Wilson
Jaye Antoinette Wilson is a winner of the fourth annual Rising Black Scientists Award for a scholar in the physical, data, earth, and environmental sciences. We asked emerging Black scientists to tell us about their scientific vision and go...
Enough with "the shakes": Fighting Parkinson's as a Black researcher and a community organizer [0.03%]
走出“震颤”的阴影：作为黑人研究者和社区组织者的抗帕金森病之路
Senegal Alfred Mabry
Senegal Alfred Mabry
Senegal Alfred Mabry is a winner of the fourth annual Rising Black Scientists Awards for a scholar in the life and health sciences. We asked emerging Black scientists to tell us about their scientific vision and goals, experiences that spar...
Akorfa Dagadu
Akorfa Dagadu
Akorfa Dagadu is a winner of the fourth annual Rising Black Scientists Awards for a scholar in the physical, data, earth, and environmental sciences. We asked emerging Black scientists to tell us about their scientific vision and goals, exp...