Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism [0.03%]
缺氧和复合体内遗传抑制因子通过相同机制拯救复合体I突变体
Joshua D Meisel,Maria Miranda,Owen S Skinner et al.
Joshua D Meisel et al.
The electron transport chain (ETC) of mitochondria, bacteria, and archaea couples electron flow to proton pumping and is adapted to diverse oxygen environments. Remarkably, in mice, neurological disease due to ETC complex I dysfunction is r...
Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death [0.03%]
通过诱导颗粒酶B介导的肿瘤细胞死亡来治疗性应用人类2型先天淋巴样细胞
Zhenlong Li,Rui Ma,Hejun Tang et al.
Zhenlong Li et al.
The therapeutic potential for human type 2 innate lymphoid cells (ILC2s) has been underexplored. Although not observed in mouse ILC2s, we found that human ILC2s secrete granzyme B (GZMB) and directly lyse tumor cells by inducing pyroptosis ...
Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA.2.86 and FLip variants [0.03%]
SARS-CoV-2 BA.2.86和FLip变种的免疫逃逸、感染性和融合性
Panke Qu,Kai Xu,Julia N Faraone et al.
Panke Qu et al.
Evolution of SARS-CoV-2 requires the reassessment of current vaccine measures. Here, we characterized BA.2.86 and XBB-derived variant FLip by investigating their neutralization alongside D614G, BA.1, BA.2, BA.4/5, XBB.1.5, and EG.5.1 by ser...
Delilah Hendriks,Anna Pagliaro,Francesco Andreatta et al.
Delilah Hendriks et al.
Human brain development involves an orchestrated, massive neural progenitor expansion while a multi-cellular tissue architecture is established. Continuously expanding organoids can be grown directly from multiple somatic tissues, yet to da...
SARS-CoV-2 BA.2.86 enters lung cells and evades neutralizing antibodies with high efficiency [0.03%]
SARS-CoV-2 BA.2.86高效进入肺细胞并躲避中和抗体
Lu Zhang,Amy Kempf,Inga Nehlmeier et al.
Lu Zhang et al.
BA.2.86, a recently identified descendant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2 sublineage, contains ∼35 mutations in the spike (S) protein and spreads in multiple countries. Here, we investigated...
Machine learning interpretable models of cell mechanics from protein images [0.03%]
从蛋白质图像中学习细胞力学的机器学习解释模型
Matthew S Schmitt,Jonathan Colen,Stefano Sala et al.
Matthew S Schmitt et al.
Cellular form and function emerge from complex mechanochemical systems within the cytoplasm. Currently, no systematic strategy exists to infer large-scale physical properties of a cell from its molecular components. This is an obstacle to u...
Direct observation of a condensate effect on super-enhancer controlled gene bursting [0.03%]
直接观察凝聚体对超级增强子控制的基因爆发的影响
Manyu Du,Simon Hendrik Stitzinger,Jan-Hendrik Spille et al.
Manyu Du et al.
Enhancers are distal DNA elements believed to loop and contact promoters to control gene expression. Recently, we found diffraction-sized transcriptional condensates at genes controlled by clusters of enhancers (super-enhancers). However, a...
A programmable reaction-diffusion system for spatiotemporal cell signaling circuit design [0.03%]
用于空间细胞信号电路设计的可编程反应扩散系统
Rohith Rajasekaran,Chih-Chia Chang,Elliott W Z Weix et al.
Rohith Rajasekaran et al.
Cells self-organize molecules in space and time to generate complex behaviors, but we lack synthetic strategies for engineering spatiotemporal signaling. We present a programmable reaction-diffusion platform for designing protein oscillatio...
Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA [0.03%]
工程连接TALE的脱氨酶以促进线粒体DNA中腺嘌呤碱基编辑的技术改进
Sung-Ik Cho,Kayeong Lim,Seongho Hong et al.
Sung-Ik Cho et al.
DddA-derived cytosine base editors (DdCBEs) and transcription activator-like effector (TALE)-linked deaminases (TALEDs) catalyze targeted base editing of mitochondrial DNA (mtDNA) in eukaryotic cells, a method useful for modeling of mitocho...
Constructing human neural circuits in living systems by transplantation [0.03%]
通过移植构建生物活体系统中的人类神经元回路
Sergiu P Pașca
Sergiu P Pașca
Our understanding of how the brain assembles its circuits and how this goes awry in disease remains incomplete. There has been great progress in generating human neurons from stem cells in vitro and, more recently, in constructing circuits ...