Christopher J Wayne,Anna K Blakney
Christopher J Wayne
In November 2023, Japan's Ministry of Health, Labour and Welfare granted regulatory approval of ARCT-154, a self-amplifying RNA COVID-19 vaccine developed by Arcturus Therapeutics. Clinical trials showed comparable safety and efficacy using...
Nancy Raab-Traub,Benjamin E Gewurz
Nancy Raab-Traub
Time-series reconstruction of the molecular architecture of human centriole assembly [0.03%]
人中心粒组装分子结构的时空重构
Marine H Laporte,Davide Gambarotto,Éloïse Bertiaux et al.
Marine H Laporte et al.
Centriole biogenesis, as in most organelle assemblies, involves the sequential recruitment of sub-structural elements that will support its function. To uncover this process, we correlated the spatial location of 24 centriolar proteins with...
Thomas W Battaglia,Iris L Mimpen,Joleen J H Traets et al.
Thomas W Battaglia et al.
Microbial communities are resident to multiple niches of the human body and are important modulators of the host immune system and responses to anticancer therapies. Recent studies have shown that complex microbial communities are present w...
A genome-wide spectrum of tandem repeat expansions in 338,963 humans [0.03%]
人类基因组中串联重复序列扩增的全基因组谱系研究
Ya Cui,Wenbin Ye,Jason Sheng Li et al.
Ya Cui et al.
The Genome Aggregation Database (gnomAD), widely recognized as the gold-standard reference map of human genetic variation, has largely overlooked tandem repeat (TR) expansions, despite the fact that TRs constitute ∼6% of our genome and are...
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation [0.03%]
人类iPSCTau病模型发现tau蛋白传播的调节因子
Celeste Parra Bravo,Alice Maria Giani,Jesus Madero-Perez et al.
Celeste Parra Bravo et al.
Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to a lack of appropriate human models. Here, we engineered human induced pluripotent stem cell (hiPSC)-derived neuronal ...
Kuo Liu,Xinfeng Meng,Zixin Liu et al.
Kuo Liu et al.
Alveolar type 2 (AT2) cells are stem cells of the alveolar epithelia. Previous genetic lineage tracing studies reported multiple cellular origins for AT2 cells after injury. However, conventional lineage tracing based on Cre-loxP has the li...
Infant microbes and metabolites point to childhood neurodevelopmental disorders [0.03%]
婴儿微生物和代谢物与儿童神经发育障碍的关系
Angelica P Ahrens,Tuulia Hyötyläinen,Joseph R Petrone et al.
Angelica P Ahrens et al.
This study has followed a birth cohort for over 20 years to find factors associated with neurodevelopmental disorder (ND) diagnosis. Detailed, early-life longitudinal questionnaires captured infection and antibiotic events, stress, prenatal...
Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria [0.03%]
弗雷明汉心脏研究中的肠道微生物组和代谢组谱分析揭示了胆固醇代谢细菌
Chenhao Li,Martin Stražar,Ahmed M T Mohamed et al.
Chenhao Li et al.
Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an altered gut microbiome. Our understanding of the underlying mechanisms has been hindered by lack of matched multi-omic data with diagnostic biomarkers. T...
Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling [0.03%]
绘制结肠炎细胞生物地理图谱揭示成纤维细胞轨迹及空间重塑的协调作用
Paolo Cadinu,Kisha N Sivanathan,Aditya Misra et al.
Paolo Cadinu et al.
Gut inflammation involves contributions from immune and non-immune cells, whose interactions are shaped by the spatial organization of the healthy gut and its remodeling during inflammation. The crosstalk between fibroblasts and immune cell...