Thomas W Battaglia,Iris L Mimpen,Joleen J H Traets et al.
Thomas W Battaglia et al.
Microbial communities are resident to multiple niches of the human body and are important modulators of the host immune system and responses to anticancer therapies. Recent studies have shown that complex microbial communities are present w...
A genome-wide spectrum of tandem repeat expansions in 338,963 humans [0.03%]
人类基因组中串联重复序列扩增的全基因组谱系研究
Ya Cui,Wenbin Ye,Jason Sheng Li et al.
Ya Cui et al.
The Genome Aggregation Database (gnomAD), widely recognized as the gold-standard reference map of human genetic variation, has largely overlooked tandem repeat (TR) expansions, despite the fact that TRs constitute ∼6% of our genome and are...
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation [0.03%]
人类iPSCTau病模型发现tau蛋白传播的调节因子
Celeste Parra Bravo,Alice Maria Giani,Jesus Madero-Perez et al.
Celeste Parra Bravo et al.
Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to a lack of appropriate human models. Here, we engineered human induced pluripotent stem cell (hiPSC)-derived neuronal ...
Kuo Liu,Xinfeng Meng,Zixin Liu et al.
Kuo Liu et al.
Alveolar type 2 (AT2) cells are stem cells of the alveolar epithelia. Previous genetic lineage tracing studies reported multiple cellular origins for AT2 cells after injury. However, conventional lineage tracing based on Cre-loxP has the li...
Infant microbes and metabolites point to childhood neurodevelopmental disorders [0.03%]
婴儿微生物和代谢物与儿童神经发育障碍的关系
Angelica P Ahrens,Tuulia Hyötyläinen,Joseph R Petrone et al.
Angelica P Ahrens et al.
This study has followed a birth cohort for over 20 years to find factors associated with neurodevelopmental disorder (ND) diagnosis. Detailed, early-life longitudinal questionnaires captured infection and antibiotic events, stress, prenatal...
Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria [0.03%]
弗雷明汉心脏研究中的肠道微生物组和代谢组谱分析揭示了胆固醇代谢细菌
Chenhao Li,Martin Stražar,Ahmed M T Mohamed et al.
Chenhao Li et al.
Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an altered gut microbiome. Our understanding of the underlying mechanisms has been hindered by lack of matched multi-omic data with diagnostic biomarkers. T...
Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling [0.03%]
绘制结肠炎细胞生物地理图谱揭示成纤维细胞轨迹及空间重塑的协调作用
Paolo Cadinu,Kisha N Sivanathan,Aditya Misra et al.
Paolo Cadinu et al.
Gut inflammation involves contributions from immune and non-immune cells, whose interactions are shaped by the spatial organization of the healthy gut and its remodeling during inflammation. The crosstalk between fibroblasts and immune cell...
Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells [0.03%]
癌细胞源性Tau通过SLC6A6介导的CD8+t细胞 Tau摄取促进免疫检查点基因表达及T细胞衰竭诱导作用
Tianyu Cao,Wenyao Zhang,Qi Wang et al.
Tianyu Cao et al.
Taurine is used to bolster immunity, but its effects on antitumor immunity are unclear. Here, we report that cancer-related taurine consumption causes T cell exhaustion and tumor progression. The taurine transporter SLC6A6 is correlated wit...
Barcoding of episodic memories in the hippocampus of a food-caching bird [0.03%]
食储鸟海马脑中关于时序记忆的条形码机制神经系统实验研究
Selmaan N Chettih,Emily L Mackevicius,Stephanie Hale et al.
Selmaan N Chettih et al.
The hippocampus is critical for episodic memory. Although hippocampal activity represents place and other behaviorally relevant variables, it is unclear how it encodes numerous memories of specific events in life. To study episodic coding, ...
The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity [0.03%]
SPATA5-SPATA5L1解旋酶复合体调控复制叉蛋白稳态以维持基因组稳定性
Vidhya Krishnamoorthy,Martina Foglizzo,Robert L Dilley et al.
Vidhya Krishnamoorthy et al.
Ubiquitin-dependent unfolding of the CMG helicase by VCP/p97 is required to terminate DNA replication. Other replisome components are not processed in the same fashion, suggesting that additional mechanisms underlie replication protein turn...