Rebecca A Green,Renat N Khaliullin,Zhiling Zhao et al.
Rebecca A Green et al.
Systematic functional profiling of the gene set that directs embryonic development is an important challenge. To tackle this challenge, we used 4D imaging of C. elegans embryogenesis to capture the effects of 500 gene knockdowns and develop...
Philip Francis Thomsen,Mads Reinholdt Jensen,Eva Egelyng Sigsgaard
Philip Francis Thomsen
Environmental DNA (eDNA) has opened promising avenues for establishing standardized, cost-efficient monitoring of biodiversity. However, comprehensive and systematic implementation is urgently needed to address the current biodiversity cris...
ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity [0.03%]
ARID1A通过抑制R-loop介导的STING型I干扰素通路活化抗肿瘤免疫反应
Matthew B Maxwell,Marianne S Hom-Tedla,Jawoon Yi et al.
Matthew B Maxwell et al.
Clinical trials have identified ARID1A mutations as enriched among patients who respond favorably to immune checkpoint blockade (ICB) in several solid tumor types independent of microsatellite instability. We show that ARID1A loss in murine...
An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis [0.03%]
造血干细胞到血小板分化进程中年龄渐进式的血小板生成加剧了血栓形成
Donna M Poscablo,Atesh K Worthington,Stephanie Smith-Berdan et al.
Donna M Poscablo et al.
Platelet dysregulation is drastically increased with advanced age and contributes to making cardiovascular disorders the leading cause of death of elderly humans. Here, we reveal a direct differentiation pathway from hematopoietic stem cell...
Sergi Junyent,Maciej Meglicki,Roman Vetter et al.
Sergi Junyent et al.
Retrospective lineage reconstruction of humans predicts that dramatic clonal imbalances in the body can be traced to the 2-cell stage embryo. However, whether and how such clonal asymmetries arise in the embryo is unclear. Here, we performe...
Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor [0.03%]
Osr2充当一种生物力学检查点以加剧肿瘤中CD8⁺T细胞的衰竭
Jinjia Zhang,Junhong Li,Yongqiang Hou et al.
Jinjia Zhang et al.
Alterations in extracellular matrix (ECM) architecture and stiffness represent hallmarks of cancer. Whether the biomechanical property of ECM impacts the functionality of tumor-reactive CD8+ T cells remains largely unknown. Here, we reveal ...
Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin [0.03%]
有脊椎动物的着丝点在有丝分裂中是有功能的双相结构，并通过粘连素得到稳定
Carlos Sacristan,Kumiko Samejima,Lorena Andrade Ruiz et al.
Carlos Sacristan et al.
Centromeres are scaffolds for the assembly of kinetochores that ensure chromosome segregation during cell division. How vertebrate centromeres obtain a three-dimensional structure to accomplish their primary function is unclear. Using super...
Spinal projecting neurons in rostral ventromedial medulla co-regulate motor and sympathetic tone [0.03%]
脑干腹内侧延髓中上行和下行投射神经元的分离及鉴定
Zicong Zhang,Junfeng Su,Jing Tang et al.
Zicong Zhang et al.
Many behaviors require the coordinated actions of somatic and autonomic functions. However, the underlying mechanisms remain elusive. By opto-stimulating different populations of descending spinal projecting neurons (SPNs) in anesthetized m...
Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact [0.03%]
血管周围神经元通过神经血管接触指导三维血管晶格形成
Kenichi Toma,Mengya Zhao,Shaobo Zhang et al.
Kenichi Toma et al.
The vasculature of the central nervous system is a 3D lattice composed of laminar vascular beds interconnected by penetrating vessels. The mechanisms controlling 3D lattice network formation remain largely unknown. Combining viral labeling,...
Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster [0.03%]
基于果蝇突触位点电子显微镜图像的神经递质分类
Nils Eckstein,Alexander Shakeel Bates,Andrew Champion et al.
Nils Eckstein et al.
High-resolution electron microscopy of nervous systems has enabled the reconstruction of synaptic connectomes. However, we do not know the synaptic sign for each connection (i.e., whether a connection is excitatory or inhibitory), which is ...