Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma [0.03%]
特异性的人类神经血管生态位早期菱形唇Protogenin⁺干/祖细胞启动并维持第3组髓母细胞瘤发生发展
Abhirami Visvanathan,Olivier Saulnier,Chuan Chen et al.
Abhirami Visvanathan et al.
We identify a population of Protogenin-positive (PRTG+ve) MYChigh NESTINlow stem cells in the four-week-old human embryonic hindbrain that subsequently localizes to the ventricular zone of the rhombic lip (RLVZ). Oncogenic transformation of...
Neoadjuvant PARPi or chemotherapy in ovarian cancer informs targeting effector Treg cells for homologous-recombination-deficient tumors [0.03%]
卵巢癌的新辅助PARP抑制剂或化疗指导针对同源重组缺陷肿瘤效应调节性T细胞的治疗
Yikai Luo,Yu Xia,Dan Liu et al.
Yikai Luo et al.
Homologous recombination deficiency (HRD) is prevalent in cancer, sensitizing tumor cells to poly (ADP-ribose) polymerase (PARP) inhibition. However, the impact of HRD and related therapies on the tumor microenvironment (TME) remains elusiv...
Jiali Yu,Yijian Yan,Shasha Li et al.
Jiali Yu et al.
Immune tolerance mechanisms are shared in cancer and pregnancy. Through cross-analyzing single-cell RNA-sequencing data from multiple human cancer types and the maternal-fetal interface, we found B7-H4 (VTCN1) is an onco-fetal immune tolera...
TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry [0.03%]
TMPRSS2和糖蛋白受体协同促进冠状病毒的入侵
Haofeng Wang,Xiaoce Liu,Xiang Zhang et al.
Haofeng Wang et al.
The entry of coronaviruses is initiated by spike recognition of host cellular receptors, involving proteinaceous and/or glycan receptors. Recently, TMPRSS2 was identified as the proteinaceous receptor for HCoV-HKU1 alongside sialoglycan as ...
Matthew McCallum,Young-Jun Park,Cameron Stewart et al.
Matthew McCallum et al.
The human coronavirus HKU1 spike (S) glycoprotein engages host cell surface sialoglycans and transmembrane protease serine 2 (TMPRSS2) to initiate infection. The molecular basis of HKU1 binding to TMPRSS2 and determinants of host receptor t...
The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation [0.03%]
地塞米松挽救重度COVID-19患者生命的作用与单核细胞功能逆转相关
Rainer Knoll,Elisa T Helbig,Kilian Dahm et al.
Rainer Knoll et al.
Dexamethasone is a life-saving treatment for severe COVID-19, yet its mechanism of action is unknown, and many patients deteriorate or die despite timely treatment initiation. Here, we identify dexamethasone treatment-induced cellular and m...
Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus [0.03%]
TMPRSS2酶原激活及与HKU1季节性冠状病毒识别的结构基础
Ignacio Fernández,Nell Saunders,Stéphane Duquerroy et al.
Ignacio Fernández et al.
The human seasonal coronavirus HKU1-CoV, which causes common colds worldwide, relies on the sequential binding to surface glycans and transmembrane serine protease 2 (TMPRSS2) for entry into target cells. TMPRSS2 is synthesized as a zymogen...
Koning Shen,Jenni Durieux,Cesar G Mena et al.
Koning Shen et al.
The ability of mitochondria to coordinate stress responses across tissues is critical for health. In C. elegans, neurons experiencing mitochondrial stress elicit an inter-tissue signaling pathway through the release of mitokine signals, suc...
Loss of transient receptor potential channel 5 causes obesity and postpartum depression [0.03%]
瞬时受体电位通道5的丢失导致肥胖和产后抑郁
Yongxiang Li,Tessa M Cacciottolo,Na Yin et al.
Yongxiang Li et al.
Hypothalamic neural circuits regulate instinctive behaviors such as food seeking, the fight/flight response, socialization, and maternal care. Here, we identified microdeletions on chromosome Xq23 disrupting the brain-expressed transient re...
Temporal dynamics of woolly mammoth genome erosion prior to extinction [0.03%]
更新世猛犸象灭绝前遗失基因组的动态变化规律
Marianne Dehasque,Hernán E Morales,David Díez-Del-Molino et al.
Marianne Dehasque et al.
A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population decl...