Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus
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The human seasonal coronavirus HKU1-CoV, which causes common colds worldwide, relies on the sequential binding to surface glycans and transmembrane serine protease 2 (TMPRSS2) for entry into target cells. TMPRSS2 is synthesized as a zymogen that undergoes auto... ...
