Off-the-shelf CAR-T cells could prove paradigm shifting for autoimmune diseases [0.03%]
现成的CAR-T细胞有望对自身免疫病的治疗产生范式转变的效果
Daniel J Baker,Carl H June
Daniel J Baker
Early reports suggest that chimeric antigen receptor (CAR)-T therapy has remarkable potential for treating autoimmune disease. Current approaches rely on autologous CAR-T cells, creating a bottleneck to the broad deployment of this therapy....
Hiten D Madhani
Hiten D Madhani
Epigenetic inheritance of heterochromatin requires transfer of parental H3-H4 tetramers to both daughter duplexes during replication. Three recent papers exploit yeast genetics coupled to inheritance assays and AlphaFold2-multimer predictio...
Brian S Kim
Brian S Kim
In defying conventional views that dismissed itch as trivial, I persisted in studying basophils and ILC2s in human skin and atopic dermatitis. My research on JAK inhibitors for itch ultimately led to FDA-approved drugs. This is my story of ...
Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates [0.03%]
比较改良型安卡拉痘病毒疫苗和信使rna疫苗预防类猴痘病毒感染的保护效果研究（英文）
Eric M Mucker,Alec W Freyn,Sandra L Bixler et al.
Eric M Mucker et al.
In 2022, mpox virus (MPXV) spread worldwide, causing 99,581 mpox cases in 121 countries. Modified vaccinia Ankara (MVA) vaccine use reduced disease in at-risk populations but failed to deliver complete protection. Lag in manufacturing and d...
Comparative Study
Cell. 2024 Oct 3;187(20):5540-5553.e10. DOI:10.1016/j.cell.2024.08.043 2024
Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome [0.03%]
来自2500种食品的未被探索的微生物多样性及其与人类微生物组的关系
Niccolò Carlino,Aitor Blanco-Míguez,Michal Punčochář et al.
Niccolò Carlino et al.
Complex microbiomes are part of the food we eat and influence our own microbiome, but their diversity remains largely unexplored. Here, we generated the open access curatedFoodMetagenomicData (cFMD) resource by integrating 1,950 newly seque...
5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming [0.03%]
在合子重编程过程中，5-形式胞嘧啶是RNA Pol III的激活表观遗传标记
Eleftheria Parasyraki,Medhavi Mallick,Victoria Hatch et al.
Eleftheria Parasyraki et al.
5-Methylcytosine (5mC) is an established epigenetic mark in vertebrate genomic DNA, but whether its oxidation intermediates formed during TET-mediated DNA demethylation possess an instructive role of their own that is also physiologically r...
Cryo-EM-based discovery of a pathogenic parvovirus causing epidemic mortality by black wasting disease in farmed beetles [0.03%]
基于 cryo-em 的致病细小病毒的发现：该病毒通过黑消耗病导致养殖金龟子大规模死亡
Judit J Penzes,Martin Holm,Samantha A Yost et al.
Judit J Penzes et al.
We use cryoelectron microscopy (cryo-EM) as a sequence- and culture-independent diagnostic tool to identify the etiological agent of an agricultural pandemic. For the past 4 years, American insect-rearing facilities have experienced a disti...
Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake [0.03%]
人类磷脂酰丝氨酸合成酶1的分子洞察表明其抑制可促进低密度脂蛋白摄取
Tao Long,Dongyu Li,Goncalo Vale et al.
Tao Long et al.
In mammalian cells, two phosphatidylserine (PS) synthases drive PS synthesis. Gain-of-function mutations in the Ptdss1 gene lead to heightened PS production, causing Lenz-Majewski syndrome (LMS). Recently, pharmacological inhibition of PSS1...
Structural insights into the diversity and DNA cleavage mechanism of Fanzor [0.03%]
Fanclade锌指核酸酶的结构多样性及其DNA切割机制的阐释
Peiyu Xu,Makoto Saito,Guilhem Faure et al.
Peiyu Xu et al.
Fanzor (Fz) is an ωRNA-guided endonuclease extensively found throughout the eukaryotic domain with unique gene editing potential. Here, we describe the structures of Fzs from three different organisms. We find that Fzs share a common ωRNA...
Ke Liang,Zeyu Jin,Xiechao Zhan et al.
Ke Liang et al.
Chloroplast proteins are imported via the translocon at the outer chloroplast membrane (TOC)-translocon at the inner chloroplast membrane (TIC) supercomplex, driven by an ATPase motor. The Ycf2-FtsHi complex has been identified as the chlor...