Matthew McCallum,Young-Jun Park,Cameron Stewart et al.
Matthew McCallum et al.
The human coronavirus HKU1 spike (S) glycoprotein engages host cell surface sialoglycans and transmembrane protease serine 2 (TMPRSS2) to initiate infection. The molecular basis of HKU1 binding to TMPRSS2 and determinants of host receptor t...
The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation [0.03%]
地塞米松挽救重度COVID-19患者生命的作用与单核细胞功能逆转相关
Rainer Knoll,Elisa T Helbig,Kilian Dahm et al.
Rainer Knoll et al.
Dexamethasone is a life-saving treatment for severe COVID-19, yet its mechanism of action is unknown, and many patients deteriorate or die despite timely treatment initiation. Here, we identify dexamethasone treatment-induced cellular and m...
Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus [0.03%]
TMPRSS2酶原激活及与HKU1季节性冠状病毒识别的结构基础
Ignacio Fernández,Nell Saunders,Stéphane Duquerroy et al.
Ignacio Fernández et al.
The human seasonal coronavirus HKU1-CoV, which causes common colds worldwide, relies on the sequential binding to surface glycans and transmembrane serine protease 2 (TMPRSS2) for entry into target cells. TMPRSS2 is synthesized as a zymogen...
Koning Shen,Jenni Durieux,Cesar G Mena et al.
Koning Shen et al.
The ability of mitochondria to coordinate stress responses across tissues is critical for health. In C. elegans, neurons experiencing mitochondrial stress elicit an inter-tissue signaling pathway through the release of mitokine signals, suc...
Loss of transient receptor potential channel 5 causes obesity and postpartum depression [0.03%]
瞬时受体电位通道5的丢失导致肥胖和产后抑郁
Yongxiang Li,Tessa M Cacciottolo,Na Yin et al.
Yongxiang Li et al.
Hypothalamic neural circuits regulate instinctive behaviors such as food seeking, the fight/flight response, socialization, and maternal care. Here, we identified microdeletions on chromosome Xq23 disrupting the brain-expressed transient re...
Temporal dynamics of woolly mammoth genome erosion prior to extinction [0.03%]
更新世猛犸象灭绝前遗失基因组的动态变化规律
Marianne Dehasque,Hernán E Morales,David Díez-Del-Molino et al.
Marianne Dehasque et al.
A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population decl...
Hanlin Zhang,C Kimberly Tsui,Gilberto Garcia et al.
Hanlin Zhang et al.
Cellular homeostasis is intricately influenced by stimuli from the microenvironment, including signaling molecules, metabolites, and pathogens. Functioning as a signaling hub within the cell, mitochondria integrate information from various ...
Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain [0.03%]
小胶质细胞源性C1q整合到衰老大脑的神经rna结合蛋白复合物中并影响蛋白质稳态
Nicole Scott-Hewitt,Matthew Mahoney,Youtong Huang et al.
Nicole Scott-Hewitt et al.
Neuroimmune interactions mediate intercellular communication and underlie critical brain functions. Microglia, CNS-resident macrophages, modulate the brain through direct physical interactions and the secretion of molecules. One such secret...
Stress-dependent condensate formation regulated by the ubiquitin-related modifier Urm1 [0.03%]
由泛素相关修饰酶Urm1调控的应激依赖性凝聚体形成
Lucas V Cairo,Xiaoyu Hong,Martin B D Müller et al.
Lucas V Cairo et al.
The ability of proteins and RNA to coalesce into phase-separated assemblies, such as the nucleolus and stress granules, is a basic principle in organizing membraneless cellular compartments. While the constituents of biomolecular condensate...
Preclinical proof of principle for orally delivered Th17 antagonist miniproteins [0.03%]
口服递送Th17拮抗性迷你蛋白的药代动力学和药效学原理的验证研究
Stephanie Berger,Franziska Seeger,Ta-Yi Yu et al.
Stephanie Berger et al.
Interleukin (IL)-23 and IL-17 are well-validated therapeutic targets in autoinflammatory diseases. Antibodies targeting IL-23 and IL-17 have shown clinical efficacy but are limited by high costs, safety risks, lack of sustained efficacy, an...