Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake
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In mammalian cells, two phosphatidylserine (PS) synthases drive PS synthesis. Gain-of-function mutations in the Ptdss1 gene lead to heightened PS production, causing Lenz-Majewski syndrome (LMS). Recently, pharmacological inhibition of PSS1 has been shown to s... ...
