Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis [0.03%]
五羟色胺转运蛋白通过调节肿瘤内五羟色胺轴抑制抗肿瘤免疫反应
Bo Li,James Elsten-Brown,Miao Li et al.
Bo Li et al.
Identifying additional immune checkpoints hindering antitumor T cell responses is key to the development of next-generation cancer immunotherapies. Here, we report the induction of serotonin transporter (SERT), a regulator of serotonin leve...
Integrating reproductive states and social cues in the control of sociosexual behaviors [0.03%]
整合生殖状态和社交线索以控制社会性行为
Yuping Wang,Xinli Song,Xiangmao Chen et al.
Yuping Wang et al.
Female sociosexual behaviors, essential for survival and reproduction, are modulated by ovarian hormones and triggered in the context of appropriate social cues. Here, we identify primary estrous-sensitive Cacna1h-expressing medial prefront...
Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors [0.03%]
肠道菌群代谢饮食中的植物化学物质控制PI3K抑制剂的抗癌活性
Asael Roichman,Qianying Zuo,Sunghoon Hwang et al.
Asael Roichman et al.
Phosphatidylinositol 3-kinase (PI3K) signaling is both the effector pathway of insulin and among the most frequently activated pathways in human cancer. In murine cancer models, the efficacy of PI3K inhibitors is dramatically enhanced by a ...
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain [0.03%]
偏向 Arrestin 结合的神经紧张素受体 1 阿花托剂可缓解急性疼痛和慢性疼痛
Ran Guo,Ouyang Chen,Yang Zhou et al.
Ran Guo et al.
G-protein-biased agonists have been shown to enhance opioid analgesia by circumventing β-arrestin-2 (βarr2) signaling. We previously reported that SBI-553, a neurotensin receptor 1 (NTSR1)-positive allosteric modulator biased toward βarr...
Eitan Erez Zahavi,Indrek Koppel,Riki Kawaguchi et al.
Eitan Erez Zahavi et al.
Neuronal growth and regeneration are regulated by local translation of mRNAs in axons. We examined RNA polyadenylation changes upon sensory neuron injury and found upregulation of a subset of polyadenylated B2-SINE repeat elements, hereby t...
Zhisen Yang,Hong Wei,Yulin Gan et al.
Zhisen Yang et al.
Auxin is crucial in orchestrating diverse aspects of plant growth and development and modulating responses to environmental signals. The asymmetric spatiotemporal distribution of auxin generates local gradient patterns, which are regulated ...
LoxCode in vivo barcoding reveals epiblast clonal fate bias to fetal organs [0.03%]
LoxCode 体内条形码揭示胚胎干细胞向胎儿器官的命运偏向
Tom S Weber,Christine Biben,Denise C Miles et al.
Tom S Weber et al.
Much remains to be learned about the clonal fate of mammalian epiblast cells. Here, we develop high-diversity Cre recombinase-driven LoxCode barcoding for in vivo clonal lineage tracing for bulk tissue and single-cell readout. Embryonic day...
Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development [0.03%]
gastrulation后卵黄囊样胚胎干细胞模型可作为人类胚外组织发育研究的体外模型
Borzo Gharibi,Oliver C K Inge,Irene Rodriguez-Hernandez et al.
Borzo Gharibi et al.
The amnion, an extra-embryonic tissue in mammalian embryos, is thought to provide crucial signaling, structural, and nutritional support during pregnancy. Despite its pivotal importance, studying human amnion formation and function has been...
Maria H Festing,Kubra B Akkaya-Colak,Maria M Mihaylova
Maria H Festing
Several organs undergo changes during pregnancy to accommodate fetal growth, including the small intestine. However, the signals that trigger this intestinal remodeling are not well understood. In a recent study, Ameku et al. describe an an...
Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat? [0.03%]
公共宏基因组中的线粒体DNA：机遇还是隐私威胁？
Mohamed S Sarhan,Giacomo Antonello,Hansi Weissensteiner et al.
Mohamed S Sarhan et al.
Human DNA is unavoidably present in metagenomic analyses of human microbiomes. While current protocols remove human DNA before submission to public repositories, mitochondrial DNA (mtDNA) has been overlooked and frequently persists. We disc...