Resistance to Striga parasitism through reduction of strigolactone exudation [0.03%]
通过减少赤霉素外渗来抵抗Striga寄生
Jiayang Shi,Cuo Mei,Fengyong Ge et al.
Jiayang Shi et al.
Parasitism with Striga poses a major threat to global food production. Striga germination and growth rely on strigolactones (SLs) exuded by crop roots under phosphate (Pi)-deficient conditions, although the mechanism of this host-parasite i...
ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation [0.03%]
ArfGAP2促进STING质子通道活性、细胞因子转运和自身炎症
Subhajit Poddar,Samuel D Chauvin,Christopher H Archer et al.
Subhajit Poddar et al.
Stimulator of interferon genes (STING) transmits signals downstream of the cytosolic DNA sensor cyclic guanosine monophosphate-AMP synthase (cGAS), leading to transcriptional upregulation of cytokines. However, components of the STING signa...
Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice [0.03%]
不同错配修复复合体基因决定了亨廷顿小鼠神经元CAG重复序列的扩增速率及其特异性病理变化
Nan Wang,Shasha Zhang,Peter Langfelder et al.
Nan Wang et al.
Huntington's disease (HD) modifiers include mismatch-repair (MMR) genes, but their connections to neuronal pathogenesis remain unclear. Here, we genetically tested 9 HD genome-wide association study (GWAS)/MMR genes in mutant Huntingtin (mH...
Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2 [0.03%]
肺源性促血栓微环境通过整合素β2驱动癌症相关血栓和转移的形成及应用抗氧化剂治疗的可能性研究外泌体机制研究
Serena Lucotti,Yusuke Ogitani,Candia M Kenific et al.
Serena Lucotti et al.
Cancer is a systemic disease with complications beyond the primary tumor site. Among them, thrombosis is the second leading cause of death in patients with certain cancers (e.g., pancreatic ductal adenocarcinoma [PDAC]) and advanced-stage d...
Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution [0.03%]
中性粒细胞源性胞外囊泡通过调控补体活化促进炎症消退
Alan Y Hsu,Qingxiang Huang,Xiong Pi et al.
Alan Y Hsu et al.
Although subsets with immunosuppressive properties exist, neutrophils are typically known for their pro-inflammatory role and pathogen clearance capabilities. Here, we reveal that neutrophils can paradoxically aid in resolving inflammation ...
Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses [0.03%]
HKU5冠状病毒科体内使用ACE2受体的趋同进化分子机制
Young-Jun Park,Chen Liu,Jimin Lee et al.
Young-Jun Park et al.
DPP4 was considered a canonical receptor for merbecoviruses until the recent discovery of African bat-borne MERS-related coronaviruses using ACE2. The extent and diversity of ACE2 utilization among merbecoviruses and their receptor species ...
Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses [0.03%]
中东呼吸综合征相关冠状病毒多次独立获得ACE2使用能力
Cheng-Bao Ma,Chen Liu,Young-Jun Park et al.
Cheng-Bao Ma et al.
The angiotensin-converting enzyme 2 (ACE2) receptor is shared by various coronaviruses with distinct receptor-binding domain (RBD) architectures, yet our understanding of these convergent acquisition events remains elusive. Here, we report ...
Jaime L Schneider,Kiran Kurmi,Yutong Dai et al.
Jaime L Schneider et al.
Little is known about metabolic vulnerabilities in oncogene-driven lung cancer. Here, we perform a phosphoproteomic screen in anaplastic lymphoma kinase (ALK)-rearranged ("ALK+") patient-derived cell lines and identify guanylate kinase 1 (G...
Gianluca Mauri,Giorgio Patelli,Giovanni Crisafulli et al.
Gianluca Mauri et al.
The incidence of early-onset colorectal cancer (EO-CRC) is surging, and by 2030, one-third of all CRCs will occur before the commonly recommended screening age of 50 years. The time required for EO-CRC to reach the metastatic stage is unkno...
Inspiring the next generation of engineers and scientists to be champions of equitable change [0.03%]
激励下一代工程师和科学家成为公平变革的倡导者
Nyasha Milanzi
Nyasha Milanzi
Nyasha Milanzi is a winner of the fifth annual Rising Black Scientists Awards for a scholar in the physical, data, earth, and environmental sciences. We asked emerging Black scientists to tell us about their scientific vision and goals, exp...