Michael D Gershon
Michael D Gershon
In this issue of Cell, Yang and colleagues demonstrate that autocrine activation of serotonin receptors on tumor-infiltrating CD8+ T cells enhances antitumor immunity. Modulating serotonin signaling may provide a new approach to therapy for...
Luísa V Lopes,Paula A Pousinha
Luísa V Lopes
In this issue of Cell, Harris et al. reveal that high-molecular-weight soluble tau-rather than amyloid-beta-impairs burst firing in hippocampal neurons, providing a mechanistic link to cognitive decline in Alzheimer's disease. This disrupti...
Yan-Gang Sun,Qingming Luo,Mu-Ming Poo
Yan-Gang Sun
Advances in brain mapping technologies have made substantial progress in identifying diverse cell types and their connectivity. Focusing on papers recently contributed by the Mesoscopic Brain Mapping Consortium to Cell, Neuron, and Developm...
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy [0.03%]
运动诱导的微生物代谢物通过促进免疫治疗效果来增强CD8 T细胞抗肿瘤免疫力
Catherine M Phelps,Nathaniel B Willis,Tingting Duan et al.
Catherine M Phelps et al.
Exercise improves immune checkpoint inhibitor (ICI) efficacy in cancers such as melanoma; however, the mechanisms through which exercise mediates this antitumor effect remain obscure. Here, we identify that the gut microbiota plays a critic...
Modeling the vertebrate regulatory sequence landscape by UUATAC-seq and deep learning [0.03%]
UUATAC-seq和深度学习建模脊椎动物调控序列图谱
Xiaoping Han,Hanyu Wu,Xueyi Wang et al.
Xiaoping Han et al.
The regulatory sequences of vertebrate genomes remain incompletely understood. To address this, we developed an ultra-throughput, ultra-sensitive single-nucleus assay for transposase-accessible chromatin using sequencing (UUATAC-seq) protoc...
Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition [0.03%]
携带非核苷抑制剂的麻疹病毒复制酶复合体结构及抑制机制研究
Yiru Wang,Lixia Zhao,Yi Zhang et al.
Yiru Wang et al.
The measles virus (MeV), a highly contagious non-segmented negative-sense RNA virus in the Paramyxoviridae family, causes millions of infections annually, with no approved antivirals available. The viral polymerase complex, comprising the l...
Advancing protein evolution with inverse folding models integrating structural and evolutionary constraints [0.03%]
基于结构和进化约束的逆向折叠模型推动蛋白质进化
Hongyuan Fei,Yunjia Li,Yijing Liu et al.
Hongyuan Fei et al.
Protein engineering enables artificial protein evolution through iterative sequence changes, but current methods often suffer from low success rates and limited cost effectiveness. Here, we present AI-informed constraints for protein engine...
A natural gene on-off system confers field thermotolerance for grain quality and yield in rice [0.03%]
水稻田间高温抗性自然基因开关型调控系统可保护籽粒品质和产量
Wei Li,Ke Yang,Chaofan Hu et al.
Wei Li et al.
Published Erratum
Cell. 2025 Jul 3:S0092-8674(25)00744-5. DOI:10.1016/j.cell.2025.06.041 2025
Recessive epistasis of a synonymous mutation confers cucumber domestication through epitranscriptomic regulation [0.03%]
同义突变通过表转录调控制约黄瓜驯化
Tongxu Xin,Zhen Zhang,Yueying Zhang et al.
Tongxu Xin et al.
Synonymous mutations, once known as "silent" mutations, are increasingly attracting the interest of biologists. Although they may affect transcriptional or post-transcriptional processes, their impact on biological traits remains under-inve...
Development of clinically viable non-muscle myosin II small molecule inhibitors [0.03%]
临床可行的非肌肉肌球蛋白II小分子抑制剂的研发
Laszlo Radnai,Erica J Young,Carlos Kikuti et al.
Laszlo Radnai et al.
Non-muscle myosin II (NMII), a molecular motor that regulates critical processes such as cytokinesis and neuronal plasticity, has substantial therapeutic potential. However, translating this potential to in vivo use has been hampered by a l...