A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation [0.03%]
一种细胞特异性机制驱动经颅磁刺激的快速抗抑郁作用
Michael W Gongwer,Alex Qi,Alexander S Enos et al.
Michael W Gongwer et al.
Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for brain disorders, but its therapeutic mechanism is poorly understood. We developed a mouse model of rTMS with superior clinical face validity and investigated t...
Virological characteristics of SARS-CoV-2-related coronaviruses dynamically circulating in Southeast Asia [0.03%]
东南亚地区动态流行的SARS-CoV-2相关冠状病毒的病毒学特征
Supaporn Wacharapluesadee,Wilaiporn Saikruang,Spyros Lytras et al.
Supaporn Wacharapluesadee et al.
By sampling horseshoe bats-the reservoir hosts of SARS-CoV-2-related coronaviruses (SC2r-CoVs)-in Thailand, we present two clades of SC2r-CoVs co-circulating in the same bat population. Through a comprehensive set of experimental approaches...
Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections [0.03%]
成熟的B细胞反应导致中和I型干扰素从而导致严重的病毒感染
Morgane Fournier,Matthias Vanderkerken,Karim Dorgham et al.
Morgane Fournier et al.
Autoantibodies neutralizing type-I interferons (AAN-I-IFNs) emerge as global, common, and strong determinants of a growing number of severe viral diseases. We report that AAN-I-IFNs+ patients with life-threatening COVID-19 pneumonia harbor ...
Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome [0.03%]
多队列蛋白基因组分析揭示了蛋白质组和疾病网络中的遗传效应
Mine Koprulu,Karl Smith-Byrne,Brian Richard Ferolito et al.
Mine Koprulu et al.
Understanding the genetic regulation of circulating protein levels can provide new insights into disease mechanisms. Here, we present the largest proteogenomic study to date (n = 78,664 participants across 38 studies), identifying >24,000 p...
Ben Sang,Ling Feng Ye,Zheng Fu et al.
Ben Sang et al.
Tri-complex inhibitors (TCIs) are molecular glues that bind the active, guanosine triphosphate (GTP)-bound state of RAS and recruit cyclophilin A (CYPA) to form a synthetic complex that blocks oncogenic signaling. Although these agents have...
Biodiversity and biogeography of the multi-kingdom cancer microbiome [0.03%]
癌症微生物组的多领域生物多样性和生物地理学分布
Anders B Dohlman,Robin Mjelle,Henry M Wood et al.
Anders B Dohlman et al.
Microorganisms represent an important component of the tumor microenvironment, but conflicting reports have left the extent of microbial prevalence across cancer types unclear, necessitating more robust methods for characterizing tumor-asso...
Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells [0.03%]
遗传变异揭示了一个可调控造血干细胞的同源异型长非编码RNA
Peng Lyu,Gaurav Agarwal,Chun-Jie Guo et al.
Peng Lyu et al.
The HOXA gene locus coordinates body patterning, hematopoiesis, and differentiation. While studying blood phenotype-associated variation within the HOXA locus, we identified a genetic variant, rs17437411, associated with globally reduced bl...
An anaerobic pathogen rewires host metabolism to fuel oxidative growth in the inflamed gut [0.03%]
肠道厌氧病原体重构宿主代谢以驱动炎症肠道内的需氧生长
Luisella Spiga,Ryan T Fansler,Yifan Wu et al.
Luisella Spiga et al.
To colonize their host and cause disease, enteric pathogens must deploy their virulence factors to establish distinct nutrient niches. How anaerobic pathogens construct nutrient niches in the densely populated large intestine remains poorly...
Distinct in vivo dynamics of donor-derived stem cell memory CAR T cells post-allogeneic HSCT relapse [0.03%]
异基因造血干细胞移植后复发的体内供体来源的记忆CAR-T细胞的独特动态变化
Luca Gattinoni,Gabriele Inchingolo,Dennis C Harrer et al.
Luca Gattinoni et al.
Donor-derived CD19-CAR T cells offer a therapeutic option for B cell malignancies relapsing after allogeneic hematopoietic stem cell transplantation but are often constrained by poor engraftment, expansion, and persistence. In a first-in-hu...
PLANeT: Understanding and leveraging the genome of land plants for a sustainable future [0.03%]
PLANET：了解和利用陆地植物基因组以实现可持续未来
Li Wang,Mohamed Amar,Carlos I Arbizu et al.
Li Wang et al.
Land plants underpin civilization and planetary health, yet their genomic diversity remains largely uncharted. Current resources are unstandardized and scarce, lacking reference genomes for 95% of genera, 70% of families, and 51% of orders,...