Phenotypic landscape of an invasive fungal pathogen reveals its unique biology [0.03%]
表型景观揭示了入侵性真菌病原体的独特生物学特性
Michael J Boucher,Sanjita Banerjee,Meenakshi B Joshi et al.
Michael J Boucher et al.
Cryptococcus neoformans is the most common cause of fungal meningitis and the top-ranking WHO fungal priority pathogen. Only distantly related to model fungi, C. neoformans is also a powerful experimental system for exploring conserved euka...
Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes [0.03%]
神经肽赋予并重新编程切叶蚁Atta cephalotes的职能分工
Michael B Gilbert,Karl M Glastad,Maxxum Fioriti et al.
Michael B Gilbert et al.
Social insects offer powerful models to investigate mechanisms of elaborate individual behaviors comprising a cooperative community. Workers of the leafcutter ant genus Atta are extreme examples of behavioral segregation among phenotypicall...
MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma [0.03%]
MT-125通过抑制非肌肉型肌球蛋白IIA和IIB来延长胶质母细胞瘤患者的生存期
Rajappa S Kenchappa,Laszlo Radnai,Erica J Young et al.
Rajappa S Kenchappa et al.
Glioblastoma (GBM) is the most lethal of primary brain tumors. Here, we report our studies of MT-125, a small-molecule inhibitor of non-muscle myosin II. MT-125 has high brain penetrance and an excellent safety profile, blocks GBM invasion ...
Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy [0.03%]
通过诱导线粒体自噬来解开线粒体对哺乳动物多能性的影响
Daniel A Schmitz,Seiya Oura,Leijie Li et al.
Daniel A Schmitz et al.
Mitochondrial abundance and genome are crucial for cellular function, with disruptions often associated with disease. However, methods to modulate these parameters for direct functional dissection remain limited. Here, we eliminate mitochon...
The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids [0.03%]
微生物组可使长链和短链脂肪酸来源的N-酰基甘油衍生脂质发生多样化
Helena Mannochio-Russo,Vincent Charron-Lamoureux,Martijn van Faassen et al.
Helena Mannochio-Russo et al.
N-Acyl lipids are important mediators of several biological processes including immune function and stress response. To enhance the detection of N-acyl lipids with untargeted mass spectrometry-based metabolomics, we created a reference spec...
Unveiling the origins and genetic makeup of the "forgotten people": A study of the Sarmatian-period population in the Carpathian Basin [0.03%]
揭开“被遗忘的人”的起源和遗传构成：喀尔巴阡盆地萨马提亚时期人群研究
Oszkár Schütz,Zoltán Maróti,Balázs Tihanyi et al.
Oszkár Schütz et al.
The nomadic Sarmatians dominated the Pontic Steppe from the 3rd century BCE and the Great Hungarian Plain from 50 CE until the Huns' 4th-century expansion. In this study, we present a large-scale genetic analysis of 156 genomes from 1st- to...
Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling [0.03%]
神经内分泌细胞通过沙漠型 Hedgehog 信号协调再生过程
William Kong,Wan-Jin Lu,Megha Dubey et al.
William Kong et al.
Understanding the mechanisms underlying mammalian regeneration may enable development of novel regenerative therapies. We present a mechanism wherein Desert hedgehog (Dhh), secreted from epithelial neuroendocrine cells, elicits a regenerati...
Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns [0.03%]
新生儿肠道微生物群衍生的次黄嘌呤编程抗流感保护性CD8⁺T细胞反应
Joseph Stevens,Erica Culberson,Jeremy Kinder et al.
Joseph Stevens et al.
Early-life susceptibility to respiratory viral infections remains a major public health concern, yet the underlying mechanisms are poorly understood. We demonstrate that antibiotic-induced dysbiosis impairs influenza-specific CD8+ T cell im...
Sensory Neurons that Detect Stretch and Nutrients in the Digestive System [0.03%]
检测消化道伸展和营养物质的感觉神经元
Erika K Williams,Rui B Chang,David E Strochlic et al.
Erika K Williams et al.
Published Erratum
Cell. 2025 Jun 7:S0092-8674(25)00631-2. DOI:10.1016/j.cell.2025.05.043 2025
Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects [0.03%]
微生物移植导致的微生物组不匹配引发持久的代谢和免疫调节的脱靶效应
Orlando DeLeon,Mora Mocanu,Alan Tan et al.
Orlando DeLeon et al.
Fecal microbiota transplant (FMT) is an increasingly used intervention, but its suitability to restore regional gut microbiota, particularly in the small bowel (SB), must be questioned because of its predominant anaerobic composition. In hu...