Bijay P Dhungel,Hua Xu,Rajini Nagarajah et al.
Bijay P Dhungel et al.
Systemic gene therapy using adeno-associated virus (AAV) vectors is approved for the treatment of several genetic disorders, but challenges and toxicities associated with high vector doses remain. We report an alternate receptor for AAV (AA...
Optogenetics-enabled discovery of integrated stress response modulators [0.03%]
光遗传学激活集成应激反应以改善学习和记忆功能及相关疾病的治疗研究发现
Felix Wong,Alicia Li,Satotaka Omori et al.
Felix Wong et al.
The integrated stress response (ISR) is a conserved stress response that maintains homeostasis in eukaryotic cells. Modulating the ISR holds therapeutic potential for diseases including viral infection, cancer, and neurodegeneration, but fe...
Engineering yeast multicellular behaviors via synthetic adhesion and contact signaling [0.03%]
通过合成粘附和接触信号工程酵母多细胞行为
Fankang Meng,William M Shaw,Yui Kei Keith Kam et al.
Fankang Meng et al.
Multicellular coordination enhances biological complexity, yet the widely used yeast Saccharomyces cerevisiae possesses limited multicellular capabilities. Here, we expand the possibilities for engineering multicellular behaviors in yeast b...
A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma [0.03%]
一种多佐剂的个人新抗原疫苗能够产生针对黑色素瘤的强效免疫反应
Eryn Blass,Derin B Keskin,Chloe R Tu et al.
Eryn Blass et al.
Personalized neoantigen-targeting vaccines have demonstrated great promise; however, improved immunogenicity is still needed. Since antigen availability and effective T cell priming are critical for maximal immunogenicity, we tested a synth...
Identification and application of cell-type-specific enhancers for the macaque brain [0.03%]
识别和应用恒河猴大脑中细胞类型特异性增强子
Ling Li,Yiming Huang,Dengyu Lu et al.
Ling Li et al.
Genetic targeting methods for monitoring and manipulating neuronal activity are not widely used for studying the primate brain, largely owing to the lack of a cell-type-specific targeting method. Using single-cell RNA and ATAC sequencing of...
Combination antiretroviral therapy and MCL-1 inhibition mitigate HTLV-1 infection in vivo [0.03%]
抗逆转录病毒疗法和MCL-1抑制可减轻HTLV-1感染
James P Cooney,Ashley Hirons,Natasha Jansz et al.
James P Cooney et al.
This study investigated preventative and therapeutic agents against human T cell lymphotropic virus type-1 subtype-C (HTLV-1c) infection. We established and characterized a humanized mouse model of HTLV-1c infection and identified that HTLV...
High-speed mapping of whole-mouse peripheral nerves at subcellular resolution [0.03%]
用于绘制整个小鼠周围神经的高速亚细胞分辨率图谱技术
Mei-Yu Shi,Yuchen Yao,Miao Wang et al.
Mei-Yu Shi et al.
In contrast to the rapid advancements in mesoscale connectomic mapping of the mammalian brain, similar mapping of the peripheral nervous system has remained challenging due to the body size and complexity. Here, we present a high-speed bloc...
Single-neuron projectomes of macaque prefrontal cortex reveal refined axon targeting and arborization [0.03%]
单神经元投射图谱揭示了猕猴前额叶皮层精妙的轴突侧支化和目标定位
Lingfeng Gou,Yanzhi Wang,Le Gao et al.
Lingfeng Gou et al.
Cortical expansion endows advanced cognitive functions in primates, and whole-brain single-neuron projection analysis helps to elucidate underlying neural circuit mechanisms. Here, we reconstructed 2,231 single-neuron projectomes for the ma...
L John Fahrner,Emma Chen,Eric Topol et al.
L John Fahrner et al.
Rapid advancements in artificial intelligence (AI), particularly large language models (LLMs) and multimodal AI, are transforming medicine through enhancements in diagnostics, patient interaction, and medical forecasting. LLMs enable conver...
Michael A Skinnider,Gregoire Courtine,Jocelyne Bloch et al.
Michael A Skinnider et al.
In a matter of years, single-cell omics has matured from a pioneering technique employed by just a handful of specialized laboratories to become a ubiquitous feature of biological research and a key driver of scientific discovery. The wides...