Multi-chamber cardioids unravel human heart development and cardiac defects [0.03%]
多心室心脏模型解析人类心脏发育及心脏缺陷机理
Clara Schmidt,Alison Deyett,Tobias Ilmer et al.
Clara Schmidt et al.
The number one cause of human fetal death are defects in heart development. Because the human embryonic heart is inaccessible and the impacts of mutations, drugs, and environmental factors on the specialized functions of different heart com...
Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals [0.03%]
长时间的睡眠剥夺会在哺乳动物中引发类似细胞因子风暴的症状
Di Sang,Keteng Lin,Yini Yang et al.
Di Sang et al.
Most animals require sleep, and sleep loss induces serious pathophysiological consequences, including death. Previous experimental approaches for investigating sleep impacts in mice have been unable to persistently deprive animals of both r...
TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes [0.03%]
TScan-II：一种从头鉴定CD4+ T细胞表位的基因组规模平台
Mohammad H Dezfulian,Tomasz Kula,Thomas Pranzatelli et al.
Mohammad H Dezfulian et al.
CD4+ T cells play fundamental roles in orchestrating immune responses and tissue homeostasis. However, our inability to associate peptide human leukocyte antigen class-II (HLA-II) complexes with their cognate T cell receptors (TCRs) in an u...
Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system [0.03%]
可溶性ACE2介导的SARS-CoV-2通过与肾素血管紧张素系统相关蛋白结合进入细胞
Man Lung Yeung,Jade Lee Lee Teng,Lilong Jia et al.
Man Lung Yeung et al.
Published Erratum
Cell. 2023 Nov 22;186(24):5428-5432. DOI:10.1016/j.cell.2023.10.008 2023
S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis [0.03%]
金黄色葡萄球菌通过V8蛋白酶-PAR1轴促进瘙痒和搔抓引起的皮肤损伤
Liwen Deng,Flavia Costa,Kimbria J Blake et al.
Liwen Deng et al.
Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly exposed to microbes and their products. However, the role of microbes in itch generation is unknown. Here, we show that Staphylococcus aureus, a...
Lineage-specific 3D genome organization is assembled at multiple scales by IKAROS [0.03%]
IKAROS在多个尺度上组装谱系特异性三维基因组结构
Yeguang Hu,Daniela Salgado Figueroa,Zhihong Zhang et al.
Yeguang Hu et al.
A generic level of chromatin organization generated by the interplay between cohesin and CTCF suffices to limit promiscuous interactions between regulatory elements, but a lineage-specific chromatin assembly that supersedes these constraint...
Tao Che,Bryan L Roth
Tao Che
Opioids are used for pain management despite the side effects that contribute to the opioid crisis. The pursuit of non-addictive opioid analgesics remains unattained due to the unresolved intricacies of opioid actions, receptor signaling ca...
Jack Major,Shruti Naik
Jack Major
Itch exacerbates infection and inflammation-associated skin pathology. In this issue of Cell, Deng et al. identify a V8 protease released by Staphylococcus aureus triggering itch via neuronal protease-activated receptor 1. In so doing, they...
Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth [0.03%]
糖基化queuosine修饰的tRNA优化了翻译速率和胚胎后的生长
Xuewei Zhao,Ding Ma,Kensuke Ishiguro et al.
Xuewei Zhao et al.
Transfer RNA (tRNA) modifications are critical for protein synthesis. Queuosine (Q), a 7-deaza-guanosine derivative, is present in tRNA anticodons. In vertebrate tRNAs for Tyr and Asp, Q is further glycosylated with galactose and mannose to...
Yameng Zhang,Allan-Hermann Pool,Tongtong Wang et al.
Yameng Zhang et al.
The hedonic value of salt fundamentally changes depending on the internal state. High concentrations of salt induce innate aversion under sated states, whereas such aversive stimuli transform into appetitive ones under sodium depletion. Neu...