Adaptive evolution of the enigmatic Takakia now facing climate change in Tibet [0.03%]
气候变化下的西藏苔类植物Takakia的适应性进化研究
Ruoyang Hu,Xuedong Li,Yong Hu et al.
Ruoyang Hu et al.
The most extreme environments are the most vulnerable to transformation under a rapidly changing climate. These ecosystems harbor some of the most specialized species, which will likely suffer the highest extinction rates. We document the s...
Distinct molecular profiles of skull bone marrow in health and neurological disorders [0.03%]
健康状况和神经障碍下颅骨骨髓的不同的分子特征
Zeynep Ilgin Kolabas,Louis B Kuemmerle,Robert Perneczky et al.
Zeynep Ilgin Kolabas et al.
The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct ...
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions [0.03%]
人源化小鼠肝脏揭示内皮细胞对重要肝代谢功能的调控作用
Eleanna Kaffe,Manolis Roulis,Jun Zhao et al.
Eleanna Kaffe et al.
Hepatocytes, the major metabolic hub of the body, execute functions that are human-specific, altered in human disease, and currently thought to be regulated through endocrine and cell-autonomous mechanisms. Here, we show that key metabolic ...
Molecular mechanism for Tn7-like transposon recruitment by a type I-B CRISPR effector [0.03%]
I-B型CRISPR效应物招募Tn7样转座子的分子机制
Shukun Wang,Clinton Gabel,Romana Siddique et al.
Shukun Wang et al.
Tn7-like transposons have co-opted CRISPR-Cas systems to facilitate the movement of their own DNA. These CRISPR-associated transposons (CASTs) are promising tools for programmable gene knockin. A key feature of CASTs is their ability to rec...
Xufeng Chen,Qiao Lu,Hua Zhou et al.
Xufeng Chen et al.
Immune-checkpoint blockade has revolutionized cancer treatment, but some cancers, such as acute myeloid leukemia (AML), do not respond or develop resistance. A potential mode of resistance is immune evasion of T cell immunity involving aber...
Cooperative assembly confers regulatory specificity and long-term genetic circuit stability [0.03%]
合作装配赋予调控特异性和长期基因线路稳定性
Meghan D J Bragdon,Nikit Patel,James Chuang et al.
Meghan D J Bragdon et al.
A ubiquitous feature of eukaryotic transcriptional regulation is cooperative self-assembly between transcription factors (TFs) and DNA cis-regulatory motifs. It is thought that this strategy enables specific regulatory connections to be for...
Sivan Gelb,Maria K Lehtinen
Sivan Gelb
Located in each brain ventricle, choroid plexus (ChP) tissue forms a blood-CSF barrier and produces cerebrospinal fluid (CSF) and other supportive factors. Sheets of ChP epithelial cells enclose a vascularized stroma of mesenchymal, immune,...
Sparse and stereotyped encoding implicates a core glomerulus for ant alarm behavior [0.03%]
稀疏和刻板的编码行为表明核心皮质球状体涉及蚂蚁报警行为
Taylor Hart,Dominic D Frank,Lindsey E Lopes et al.
Taylor Hart et al.
Published Erratum
Cell. 2023 Aug 3;186(16):3521. DOI:10.1016/j.cell.2023.07.022 2023
Enveloped viruses pseudotyped with mammalian myogenic cell fusogens target skeletal muscle for gene delivery [0.03%]
利用哺乳动物肌源性细胞融合素假型包膜病毒进行基因递送以靶向骨骼肌
Sajedah M Hindi,Michael J Petrany,Elena Greenfeld et al.
Sajedah M Hindi et al.
Published Erratum
Cell. 2023 Aug 3;186(16):3520. DOI:10.1016/j.cell.2023.06.025 2023
Large-scale snake genome analyses provide insights into vertebrate development [0.03%]
大规模蛇类基因组分析为脊椎动物发育提供见解
Changjun Peng,Dong-Dong Wu,Jin-Long Ren et al.
Changjun Peng et al.
Published Erratum
Cell. 2023 Aug 3;186(16):3519. DOI:10.1016/j.cell.2023.06.021 2023