Human inherited CCR2 deficiency underlies progressive polycystic lung disease [0.03%]
人类继承的CCR2缺陷导致进行性多囊肺病
Anna-Lena Neehus,Brenna Carey,Marija Landekic et al.
Anna-Lena Neehus et al.
We describe a human lung disease caused by autosomal recessive, complete deficiency of the monocyte chemokine receptor C-C motif chemokine receptor 2 (CCR2). Nine children from five independent kindreds have pulmonary alveolar proteinosis (...
Extracellular pectin-RALF phase separation mediates FERONIA global signaling function [0.03%]
胞外的果胶-RALF相分离介导FERONIA全局信号功能
Ming-Che James Liu,Fang-Ling Jessica Yeh,Robert Yvon et al.
Ming-Che James Liu et al.
The FERONIA (FER)-LLG1 co-receptor and its peptide ligand RALF regulate myriad processes for plant growth and survival. Focusing on signal-induced cell surface responses, we discovered that intrinsically disordered RALF triggers clustering ...
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma [0.03%]
基于时间的单细胞转录组学定义了胶质母细胞瘤中的免疫路径
Daniel Kirschenbaum,Ken Xie,Florian Ingelfinger et al.
Daniel Kirschenbaum et al.
Deciphering the cell-state transitions underlying immune adaptation across time is fundamental for advancing biology. Empirical in vivo genomic technologies that capture cellular dynamics are currently lacking. We present Zman-seq, a single...
Masato Tamari,Kate L Del Bel,Aaron M Ver Heul et al.
Masato Tamari et al.
Cytokines employ downstream Janus kinases (JAKs) to promote chronic inflammatory diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with JAK1 gain-of-function (GoF) variants develop atopic dermatitis (AD) an...
Automatic cell-type harmonization and integration across Human Cell Atlas datasets [0.03%]
人类细胞图谱数据集中自动细胞类型统一与整合
Chuan Xu,Martin Prete,Simone Webb et al.
Chuan Xu et al.
Harmonizing cell types across the single-cell community and assembling them into a common framework is central to building a standardized Human Cell Atlas. Here, we present CellHint, a predictive clustering tree-based tool to resolve cell-t...
Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [0.03%]
脆性X综合症中长突触基因的空間協同异染色质化
Thomas Malachowski,Keerthivasan Raanin Chandradoss,Ravi Boya et al.
Thomas Malachowski et al.
Short tandem repeat (STR) instability causes transcriptional silencing in several repeat expansion disorders. In fragile X syndrome (FXS), mutation-length expansion of a CGG STR represses FMR1 via local DNA methylation. Here, we find megaba...
Martin Wilkinson,Yong Xu,Dev Thacker et al.
Martin Wilkinson et al.
Cryoelectron microscopy (cryo-EM) has provided unprecedented insights into amyloid fibril structures, including those associated with disease. However, these structures represent the endpoints of long assembly processes, and their relations...
LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons [0.03%]
LRRC37B是人类电压门控钠通道的修饰因子，并且影响皮层神经元轴突的兴奋性
Baptiste Libé-Philippot,Amélie Lejeune,Keimpe Wierda et al.
Baptiste Libé-Philippot et al.
The enhanced cognitive abilities characterizing the human species result from specialized features of neurons and circuits. Here, we report that the hominid-specific gene LRRC37B encodes a receptor expressed in human cortical pyramidal neur...
Paul J Farrell
Paul J Farrell
Autoimmune cross-reaction of specific antibodies to Epstein-Barr virus (EBV) has been associated with development of multiple sclerosis (MS). In this issue of Cell, Vietzen et al. identify additional immunological regulatory mechanisms that...
RAF-like protein kinases mediate a deeply conserved, rapid auxin response [0.03%]
类似RAF的蛋白激酶介导了快速反应的生长素应答这一古老机制
Andre Kuhn,Mark Roosjen,Sumanth Mutte et al.
Andre Kuhn et al.
The plant-signaling molecule auxin triggers fast and slow cellular responses across land plants and algae. The nuclear auxin pathway mediates gene expression and controls growth and development in land plants, but this pathway is absent fro...