Peiminine modulates T cell-associated gene expression and inflammatory activity in experimental autoimmune hepatitis [0.03%]
皮敏欣调节实验性自身免疫性肝炎的小鼠T细胞相关基因表达及炎症活性
Amin Azizan,Mohammad Ali Abyazi,Seyed Kiarash Aghayan et al.
Amin Azizan et al.
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease characterized by immune-mediated hepatocellular injury and insufficient regulatory T cell (Treg) control. Despite the efficacy of corticosteroids and azathioprine, incomplet...
Actin cytoskeleton stabilization inhibits NLRP3 inflammasome activation and mitigates renal inflammation and fibrosis in obstructive nephropathy [0.03%]
肌动蛋白细胞骨架稳定抑制NLRP3炎性小体活化并缓解阻塞性肾病的肾脏炎症和纤维化
Qiaoli Xu,Jinxin Li,Xing Wan et al.
Qiaoli Xu et al.
Obstructive nephropathy is characterized by progressive renal inflammation and tubular injury, in which the NLRP3 inflammasome plays a pivotal role. However, the contribution of cytoskeletal dynamics to inflammasome activation remains poorl...
Exosomes derived from ovarian cancer promote the progression of ovarian cancer through macrophage M2 polarization mediated by the THBS1/TGFBI signaling axis [0.03%]
卵巢癌来源的外泌体通过THBS1/TGFBI信号轴介导的M2型巨噬细胞极化促进卵巢癌进展
Linlin Yang,Yue Jia,Ying Liu et al.
Linlin Yang et al.
Background: Tumor-derived exosomes play a critical role in facilitating intercellular communication between cancer cells and tumor-associated macrophages (TAMs). Nevertheless, the precise molecular mechanisms underlying e...
Simon Fillatreau,Yi Hao
Simon Fillatreau
The immune system is conventionally viewed as an army of fighters present naturally in an inactive state, ready to react to microbial invasion. Activation follows the detection of microbial molecules either by innate receptors, which are br...
Evaluating the impact of using bone marrow-derived macrophages to turn early tumor sites into hot early tumor sites [0.03%]
评估使用骨髓来源的巨噬细胞将早期肿瘤部位转化为"热"早期肿瘤部位的影响
Joshua Finn,Emily Kessler,Melissa Lass et al.
Joshua Finn et al.
The impact of transforming an early tumor site into a hot early tumor site was evaluated using bone marrow-derived macrophages (BMDM) activated with IFN-γ and sCD40L in combination with Toll-like receptor (TLR) agonists (lipopolysaccharide...
The inflammatory effects of a repeated exposure of human macrophages to PM2.5 from house dust-SRM 2585 are partially reversible and disrupt the LPS/CD14 signaling pathways [0.03%]
人体巨噬细胞反复暴露于来自房屋灰尘的SRM 2585PM2.5引起的部分可以逆转的炎症效应会干扰LPS/CD14信号传导途径
Lelong Marie,Morin Laura,Pottier Ivannah et al.
Lelong Marie et al.
Objectives: To evaluate whether repeated exposures to house dust PM2.5, used at nontoxic concentrations, activate human macrophages after one- and seven-days post-treatment, and whether such PM2.5 exposure may alter their...
Immunomodulatory effects of mesenchymal stromal cell secretome accelerate repair in a sickle cell disease wound model [0.03%]
间充质基质细胞分泌组的免疫调节作用可加速镰状细胞病伤口模型中的修复
Brysa M Silveira,Tiago O Ribeiro,Songeli M Freire et al.
Brysa M Silveira et al.
Chronic leg ulcers (CLUs) are a debilitating complication of sickle cell disease (SCD), driven by persistent inflammation, immune dysregulation, and vascular dysfunction. Current therapies fail to correct the hostile immune microenvironment...
Mesenchymal stromal cells relieved systemic lupus erythematosus via CCL2 dependent macrophage polarization [0.03%]
间充质干细胞通过CCL2依赖的巨噬细胞极化来缓解系统性红斑狼疮
Xin Wen,Genhong Yao,Yujie Zhou et al.
Xin Wen et al.
Systemic lupus erythematosus (SLE) was an autoimmune disease leading to high morbidity and mortality without effective and low-side effect conventional drugs. Our previous clinical studies demonstrated umbilical cord derived mesenchymal str...
Differential heterologous immunological effects induced by ChAdOx1-S and BNT162b2 COVID-19 vaccines [0.03%]
异源免疫接种与国产和进口新冠疫苗的免疫学效应差异性研究
Elisabeth A Dulfer,Büsra Geckin,Martijn Zoodsma et al.
Elisabeth A Dulfer et al.
Background: The mRNA- and adenovirus-based COVID-19 vaccines may induce different heterologous effects on non-COVID morbidity. We aimed to investigate immunological mechanisms that may account for these differences. ...
Fan Zou,Yishan Zhang,Mingdong Wang et al.
Fan Zou et al.
The tumor microenvironment (TME) has emerged as a prominent focus of cancer research in recent years, with various drugs in this field, including programmed cell death receptor 1 (PD-1) antibodies and cytotoxic T lymphocyte antigen 4 (CTLA-...