Silibinin restricts mitochondria-associated inflammatory pathways in LPS-stimulated murine microglia BV2 through TREM2 [0.03%]
白花青素通过TREM2限制LPS刺激的小胶质BV2细胞中与线粒体相关的炎症途径
Wenhui Chen,Xiaoling Wang,Panwen Liu et al.
Wenhui Chen et al.
Microglia are resident immune cells in the central nervous system mediating brain inflammatory responses. The flavonoid silibinin has been found to restrict the neuronal inflammatory conditions in vivo. To fully reveal the underlying mechan...
Fengfeng Xie,Zhanhua Shi,Jiaying Zhu et al.
Fengfeng Xie et al.
Purpose: Preeclampsia (PE) is a multifactorial disease, in which immune dysregulations especially pathogenic autoantibody AT1-AA is critically involved. MFG-E8 deficiency can lead to autoimmune disorders, yet its role in ...
UVB induces DNA hypomethylation and cell activation in CD4+ T cells of systemic lupus erythematosus via miR-410 regulating GADD45A [0.03%]
紫外线通过miR-410调控GADD45A诱导系统性红斑狼疮CD4⁺T细胞DNA低甲基化和细胞活化
Zheng Cai,Zhi-Luo Cheng,Ya-Nan Tan et al.
Zheng Cai et al.
Objective: To explore the impact of ultraviolet B (UVB) on the DNA methylation and activation in CD4+ T cells of systemic lupus erythematosus (SLE) patients and the underlying mechanisms. ...
WISP-3 enhances proinflammatory cytokine IL-1β production in rheumatoid arthritis through the FAK, JNK and AP-1 pathways [0.03%]
WNIP-3通过FAK，JNK和AP-1途径增强类风湿关节炎中促炎症细胞因子IL-1β的产生
Sheng-Mou Hou,Guo-Shou Wang,Jeng-Hung Guo et al.
Sheng-Mou Hou et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, progressive joint destruction, and long-term disability. Interleukin-1β (IL-1β) is a key pro-infla...
Armed oncolytic adenovirus elicits a "self-feeder" effect to supercharge NK cells for solid tumor control [0.03%]
武装溶瘤腺病毒诱发的"自补给"效应可增强NK细胞对实体肿瘤的控制能力
Qibin Liao,Siqiang Lai,Zhongyi Fan et al.
Qibin Liao et al.
Background: Natural killer (NK) cells are pivotal effectors in innate anti-tumor immunity, but their efficacy against solid tumors is constrained by inadequate tumor infiltration and functional suppression within the tumo...
Tumor resection may abort the antitumor immune response produced from primary foci [0.03%]
肿瘤切除可能终止由原发灶产生的抗肿瘤免疫反应
Kun Xu,Bin Zhao,Jiaxin Mei et al.
Kun Xu et al.
Clinical observations suggest that after surgical removal of the primary tumor, metastases exhibit accelerated growth. This suggests that the primary tumor may exert inhibitory effects on micrometastases, and its surgical removal may conver...
The RNA-binding protein ALYREF promotes mitochondrial dysfunction and ferroptosis in CD4+ helper T cells in chronic obstructive pulmonary disease and non-small cell lung cancer by enhancing ZWINT mRNA stability [0.03%]
RNA结合蛋白ALYREF通过增强ZWINTmRNA稳定性促进慢性阻塞性肺疾病和非小细胞肺癌中CD4+辅助性T细胞的线粒体功能障碍和铁死亡
ShiMin Li,Qi Song,FuShi Dong et al.
ShiMin Li et al.
Background and aims: Immune dysfunction in the tumor microenvironment contributes to the progression of non-small cell lung cancer (NSCLC) in patients with chronic obstructive pulmonary disease (COPD). This study aimed to...
FGF20 alleviates neuroinflammation in ischemic stroke by modulating microglial polarization via TREM2-TLR4/NF-κB pathway [0.03%]
FGF20通过TREM2-TLR4/NF-κB信号通路调节小胶质细胞极化从而缓解缺血性卒中的神经炎症反应
Liyun Zhu,Shufei Guo,Zhengyi Wang et al.
Liyun Zhu et al.
Microglia play dual roles in neuroinflammation, driving either detrimental M1 or protective M2 polarization, which critically impacts the outcomes of ischemic stroke. While fibroblast growth factor 20 (FGF20) is established as a neurotrophi...
Corrigendum to "BCG and β-glucan primed monocytes yield dendritic cells that hamper the induction of pro-inflammatory T cell immunity" [Cell. Immunol. 419 (2026) 105060] [0.03%]
关于“BCG和β-葡聚糖预处理的单核细胞生成的树突状细胞可抑制促炎性T细胞免疫诱导”的勘误[细胞免疫学419(2026)105060]
Jorge Cuenca-Escalona,Robbin Kramer,Clara Marjalizo-Jimenez et al.
Jorge Cuenca-Escalona et al.
Published Erratum
Cellular immunology. 2026 Mar 10:105087. DOI:10.1016/j.cellimm.2026.105087 2026
STAT signaling pathway in pregnancy stages and related to complications [0.03%]
STAT信号通路在妊娠各阶段的表达及其与并发症的相关性研究进展
Lida Aslanian-Kalkhoran,Danial Abbas-Kabiri,Farshid Afandideh et al.
Lida Aslanian-Kalkhoran et al.
Signal transducer and activator of transcription (STAT) proteins are essential DNA-binding proteins that not only facilitate signal transduction but also play a critical role in regulating gene transcription, making them vital for cellular ...