The uptake, intracellular trafficking and recycling of FcRn-blocking therapeutics in human endothelial cells in vitro
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The neonatal Fc receptor (FcRn) recycles immunoglobulin G (IgG) in cells and is responsible for the long half-life of IgG relative to other plasma proteins. FcRn also recycles pathogenic IgG autoantibodies and is the target for several new targeted therapeutic... ...
