Macrophage polarization: A bridge connecting osteoarthritis and osteoporosis [0.03%]
巨噬细胞极化：骨关节炎和骨质疏松症之间的桥梁
Jian Cheng,Mingming Liu,Qianyu Li et al.
Jian Cheng et al.
Macrophage polarization plays a pivotal role in maintaining bone homeostasis and serves as a crucial mechanistic bridge in the comorbidity of osteoarthritis (OA) and osteoporosis (OP). Macrophages exhibit functional plasticity, polarizing i...
MPC1 deficiency promotes melanoma progression via Wnt/β-catenin signaling [0.03%]
MPC1缺乏通过Wnt / β-连环蛋白信号促进黑色素瘤进展
Qing Zhu,Mao Zhao,Weinan Guo et al.
Qing Zhu et al.
Melanoma represents the most aggressive and lethal form of skin cancer with high metastatic potential and elucidating the mechanisms underlying its progression is essential for developing effective therapies. The mitochondrial pyruvate carr...
Corrigendum to "Effect of L-theanine on the hippocampus, cerebral cortex and cerebellum of doxorubicin-treated rats" [Biochem. Biophys. Res. Commun.797 (2026) 153216] [0.03%]
硫霉素对阿霉素处理的大鼠海马、大脑皮层和小脑的影响一校正[Biochem. Biophys. Res. Commun.797 (2026) 153216]
Birgül Kural,Sevil Kör,Meltem Arıkan Malkoç et al.
Birgül Kural et al.
Betanin-encapsulated nanoparticles mitigate neurotoxicity against AlCl3-induced Alzheimer's disease via modulation of AChE/TNF-α/IL-1β expression [0.03%]
甜菜红素包载纳米粒通过调节乙酰胆碱酯酶和炎性细胞因子表达缓解铝氯所致阿尔茨海默病的神经毒性作用研究
Rabbiya Razzaq,Touqeer Ahmed,Azeem Mehmood Butt et al.
Rabbiya Razzaq et al.
Alzheimer's disease (AD), the most common health problem, is significantly characterized by oxidative stress, neuroinflammation, and cholinergic dysfunction, provoking growing interest in natural antioxidants with improved bioavailability. ...
Integrative analysis identifies lactylation-related biomarkers in sepsis via bioinformatics and machine learning [0.03%]
生物信息学和机器学习鉴定脓毒症相关的乳酰化标志物的综合分析
Haixiang Qian,Chenle Huang,Jiankang Meng et al.
Haixiang Qian et al.
Background: Protein lactylation is a novel post-translational modification driven by lactate and has emerged as a critical link between cellular metabolism and epigenetic regulation in inflammatory diseases, including sep...
Cyclin D1 and the resistance landscape of HIF2 inhibition in clear-cell renal cell carcinoma: Insights from a mini-review [0.03%]
cyclin D1与HIF2抑制在透明细胞肾细胞癌中的耐药性景观：迷你综述的见解
Zhenbang Zhong,Anqing Yang,Jinxiang Wang et al.
Zhenbang Zhong et al.
Clear-cell renal cell carcinoma (ccRCC) is primarily driven by VHL inactivation and subsequent stabilization of hypoxia-inducible factor 2α (HIF2α). The recent approval of the HIF2 inhibitor belzutifan represents a landmark advance, yet b...
Teneurin-4 in the nucleus accumbens modulates affective-like behaviors with potential effects on astrocytes in male mice [0.03%]
小鼠脑腹侧被盖区神经肽S受体在焦虑和情感相关的负性记忆消除中的作用研究
Wenbing Chen,Tomoya Kaigawa,Jun Yokose et al.
Wenbing Chen et al.
Affective disorders represent a major global health burden with limited therapeutic options. Teneurin-4 (TENM4), a cell adhesion molecule crucial for synaptic organization, has been implicated in neural circuit function, but its specific ro...
Corrigendum to "NMN synbiotics intervention modulates gut microbiota and metabolism in APP/PS1 Alzheimer's disease mouse models" [Biochem. Biophys. Res. Commun. 726 (2024) 150-274] [0.03%]
“烟酰胺单核苷酸合生元干预调节APP/PS1型阿尔茨海默病小鼠模型的肠道微生物组和代谢”的勘误表 [Biochem. Biophys. Res. Commun. 726 (2024) 150-274]
Jianing Zhang,Xiaodong Zhao,Huilian Xu et al.
Jianing Zhang et al.
Lactylation-mediated degradation of ANKS1B mitigates ischemic excitotoxicity by impairing GluN2B trafficking [0.03%]
乳酰化介导的ANKS1B降解通过损害GluN2B转运来缓解缺血性兴奋毒性
Ping Yang,Junzhao Liu,Xia Rong et al.
Ping Yang et al.
Ischemic stroke triggers a cascade of metabolic shifts and excitotoxicity, partially mediated by GluN2B-containing N-methyl-d-aspartate receptors (NMDARs). While protein lactylation has emerged as a key metabolic regulator, its role in modu...
Elucidating the mutation-induced conformational changes in hexose transporter for co-utilization of glucose and xylose [0.03%]
阐明己糖转运蛋白的突变诱导构象变化以协同利用葡萄糖和木糖
Pradipta Patra,Amit Ghosh
Pradipta Patra
Efficient co-utilization of glucose and xylose by Saccharomyces cerevisiae is crucial for economical biofuel production from renewable feedstocks. The F79S mutation in the hexose transporter HXT7 enhances xylose uptake, but the underlying m...