Hydrophobicity and signal sequence binding to the Sec complex: A single molecule biophysical perspective [0.03%]
疏水性和信号序列与Sec复合物结合的单分子生物物理研究视角
Wendy N Sánchez,Luka Robeson,Hilda M Alfaro-Valdés et al.
Wendy N Sánchez et al.
The Sec61 complex plays a critical role in protein translocation into the endoplasmic reticulum (ER), enabling the passage of soluble proteins into the lumen and the lateral insertion of membrane proteins. The Sec complex, comprising Sec61,...
CD19 CAR-macrophage suppressed the progression of DLBCL via modulating SYK/SHP2/TBK1/TFEB signaling [0.03%]
CD19 CAR-巨噬细胞通过调节SYK/SHP2/TBK1/TFEB信号抑制DLBCL进展
Xikui Zhang,Tao Wen,Pengfei Chen et al.
Xikui Zhang et al.
Objective: To explore the specific molecular mechanisms of CD19 CAR-Macrophage (CD19 CAR-M) in treating Diffuse Large B-cell Lymphoma (DLBCL). Methods: ...
Isoquercitrin alleviates sepsis-induced myocardial injury via the EGFR/PI3K/AKT signaling pathway [0.03%]
异檞皮素通过EGFR/PI3K/AKT信号通路缓解脓毒症诱导的心肌损伤
Hexin Zhai,Xingwei Yang,Yan Shao et al.
Hexin Zhai et al.
Background: Sepsis-induced myocardial injury is a life-threatening complication. Isoquercitrin (IQC), a natural flavonoid glycoside, exhibits anti-inflammatory and anti-apoptotic properties, yet its role in septic cardiom...
Nephronectin promotes ameloblast differentiation through its RGD motif [0.03%]
nephronectin通过其RGD基序促进 enamel细胞分化
Kanji Mizuta,Yuta Chiba,Tian Tian et al.
Kanji Mizuta et al.
Nephronectin (Npnt) is a multifunctional basement membrane protein containing EGF-like repeats and an RGD motif. While we previously reported that Npnt regulates dental epithelial stem cell proliferation via its EGF-like repeats, the specif...
Corrigendum to "Identification and cloning of odorant binding proteins from the scarab beetle Phyllopertha diversa" [Biochem. Biophys. Res. Commun. 263 (1999) 832-837] [0.03%]
对“多种变异象鼻虫气味结合蛋白的鉴定与克隆”[ Biochem.Biophys.Res.Commun. 263 (1999) 832-837 ] 的勘误通知
Hubert Wojtasek,Jean-François Picimbon,Walter Soares Leal
Hubert Wojtasek
Jin Wang,Ying Cai,Duanduan Wang et al.
Jin Wang et al.
DiGeorge syndrome critical region gene 8 (DGCR8) is best known as the RNA-binding subunit of the microprocessor complex required for canonical microRNA (miRNA) biogenesis. Whether DGCR8 also exerts a direct, microprocessor-independent funct...
Structural insights into UMP recognition and ligand specificity of orotidine 5'-Monophosphate decarboxylase from Fusobacterium nucleatum [0.03%]
核糖体催化反应底物识别及底物特异性的结构机制研究
Bogeun Kim,Jisub Hwang,Youn-Soo Shim et al.
Bogeun Kim et al.
Orotidine-5'-phosphate decarboxylase (OMP decarboxylase; ODCase) catalyzes a key step in de novo pyrimidine biosynthesis by converting orotidine-5'-monophosphate to uridine-5'-monophosphate. Despite its essential metabolic role, the structu...
AKAP12 is upregulated by base deletion at positions 61-78 in exon 3, leading to suppressed proliferation and metastasis of benzo[a]pyrene-transformed HBE cells [0.03%]
碱基缺失诱导的AKAP12上调通过抑制细胞增殖和转移阻断苯并[a]芘致支气管上皮细胞恶性转化
Mingmei Hao,Yujin Fu,Yitong Lin et al.
Mingmei Hao et al.
The carcinogenic mechanism of benzo[a]pyrene (BaP) is not fully understood. Our previous studies unexpectedly revealed that A-kinase anchoring protein 12 (AKAP12), a recognized tumor suppressor frequently downregulated in malignancies, is m...
Corrigendum to "Tepraloxydim metabolite exposure disrupts placental function revealed by single-cell sequencing and metabolomics" [Biochem. Biophys. Res. Commun. 827 (2026) 154073] [0.03%]
关于“单细胞测序和代谢组学揭示Tepraloxydim代谢物暴露干扰胎盘功能”[Biochem. Biophys. Res. Commun. 827 (2026) 154073]的勘误通知
Yunfei Teng,Zhou Qi,Jie Han et al.
Yunfei Teng et al.
AC137932.2 reinforces hypoxia-driven glycolytic remodeling in triple-negative breast cancer through an IGF2BP2/HIF-1α positive feedback loop [0.03%]
通过IGF2BP2/HIF-1α正反馈环促进三阴性乳腺癌低氧驱动的糖酵解重构的AC137932.2
Wenliang Lu,Wei Wang,Bo Chen et al.
Wenliang Lu et al.
Background: Triple-negative breast cancer (TNBC) displays aggressive progression and pronounced hypoxia-driven metabolic remodeling. However, whether the long non-coding RNA AC137932.2 mechanistically links hypoxia signal...