Sleep deprivation exacerbates hepatic steatosis by promoting hepatic inflammation and oxidative stress through gut microbiota dysbiosis in metabolic dysfunction-associated fatty liver disease rat [0.03%]
Hou Hui,Abulizi Guzailiayi,He Sirui et al.
Hou Hui et al.
Objective: The study aimed to explore the impact of sleep deprivation on hepatic steatosis in metabolic dysfunction-associated fatty liver disease (MASLD) and its possible mechanisms. ...
Case study, clinical trials, critical analysis and mechanistic overview of conventional and resistant breast cancer treatment using functionalized albumin nanoparticles: a comprehensive review [0.03%]
Shuvadip Bhowmik,Abhimanyu Dev
Shuvadip Bhowmik
Albumin nanoparticles have emerged as a promising drug delivery platform for targeted breast cancer therapy, offering advantages such as biocompatibility, non-toxicity, and the ability to overcome drug resistance. This comprehensive review ...
Structure of a chimeric RORα ligand-binding domain in fusion with a RIP-140 coactivator peptide [0.03%]
Xiaojie Li,Gongchun Zhang,Lingchen Tan et al.
Xiaojie Li et al.
The retinoic acid-related orphan receptor α (RORα) is a potential drug target for cancer, inflammation, and metabolic diseases. Structure-guided ligand optimization can facilitate the development of selective RORα modulators. However, st...
Matrix metalloproteinase-3 (MMP3) in non-syndromic cleft lip and palate: extracellular matrix remodeling, developmental signaling, and molecular mechanisms [0.03%]
Jean Rodrigues Evangelista,Christian Ferreira Bernardi,Alessandra V S Faria et al.
Jean Rodrigues Evangelista et al.
Non-syndromic cleft lip and/or palate is one of the most common congenital craniofacial malformations and results from disruptions in tightly regulated developmental processes during early embryogenesis. Although non-syndromic cleft lip and...
Identification of non-toxic AAV capsid variants with enhanced deep retinal transduction and extended distribution following subretinal delivery [0.03%]
Hoon Lim,Seungho Choi,Ye-Eun Jeon et al.
Hoon Lim et al.
Subretinal injection remains the standard method for delivering genes to the retina. However, diffusion into deeper retinal layers is often limited by sequestration of wild-type AAV2 vectors at the retinal pigment epithelium (RPE). In this ...
Decoding antibiotic resistance in tuberculosis: Role of RRDR and non-RRDR mutations in diagnostic perspectives [0.03%]
Risha Hazarika,Sanjukta Patra
Risha Hazarika
Rifampicin resistance continues to pose a challenge to successful tuberculosis (TB) control, mainly driven by mutations in the rpoB gene of Mycobacterium tuberculosis. Although most diagnostic tools, such as Xpert MTB/RIF, Xpert Ultra, and ...
Emerging strategies in exosome engineering: From cellular preconditioning to hybridization for targeted therapeutics [0.03%]
Rafie Belali,Maryam Jafar Sameri
Rafie Belali
Exosomes are nanosized extracellular vesicles that originate from all cell types. They have a precious role in intercellular communication and therapeutic delivery. Exosomes are considered attractive candidates because of their innate bioco...
Mogroside V alleviates diquat-induced renal tubular epithelial cell injury via the TUG1/miR-29-3p/SIRT1 axis [0.03%]
Hao Li,Wenli Shang,Xinbing Xu et al.
Hao Li et al.
Mogroside V (MV), a major bioactive component isolated from Siraitia grosvenorii, exhibits diverse pharmacological properties, yet its protective role in toxin-induced renal injury remains incompletely defined. This study investigated the e...
High concentrations of GW9508 enhance sperm velocity in mice via peroxisome proliferator-activated receptor γ [0.03%]
Ryutaro Moriyama,Aika Tuji,Shunya Ikeda et al.
Ryutaro Moriyama et al.
In this study, we investigated the effects of GW9508, a well-known long-chain fatty acid receptor agonist, on mouse sperm function and its underlying target molecules. RT-PCR analysis detected mRNA expression of Gpr120 and Pparγ in mouse t...
Chengyao Ni,Peng Hu,Yiming Ni
Chengyao Ni
Heart failure (HF) is associated with mitochondrial quality control, a key process in quality control. Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) regulates mitophagy, but its role in HF remains unclear. This st...