Glucocerebrosidase rescues alpha-synuclein from amyloid formation in vitro [0.03%]
葡糖脑苷脂酶通过体外实验抑制α-突触核蛋白的淀粉样纤维化作用
Michael Barber,Henrik Muller,Robert J C Gilbert et al.
Michael Barber et al.
Alpha-synuclein (αSyn) is a lipid-binding protein that assembles into amyloid fibrils in Parkinson's disease (PD). Lipid binding can accelerate the rate of αSyn fibril formation by stimulating primary nucleation. Recently, the lysosomal p...
Epitope-guided detection of a molecular glue-induced ternary complex using engineered synthetic antibody fragments [0.03%]
表位导向检测分子胶诱导的三元复合物采用工程化合成抗体片段方法
Kelly M O&#x;Leary,Tomasz Slezak,Duc Anh Le et al.
Kelly M O&#x;Leary et al.
Molecular glues represent a class of small molecules that enable the modulation of proteins lacking traditional ligand-binding pockets. A defining feature of molecular glues is their ability to bind cooperatively at weak or neomorphic prote...
The role of SLC24A5 (NCKX5) in human skin pigmentation: the importance of cation transport activity [0.03%]
SLC24A5(NCKX5)在人类皮肤色素沉着中的作用及阳离子转运活性的重要性
Tatiana Rogasevskaia,Ali H Jalloul,Robert T Szerencsei et al.
Tatiana Rogasevskaia et al.
Human pigmentation is determined by melanosome development and melanin production through melanogenesis, a process regulated by melanogenic proteins. A single nucleotide polymorphism (A111T) in the SLC24A5 gene, which encodes the K⁺-depend...
The Advantages of AI for Computational Protein Studies and Looking Ahead at the Next Challenges: Single Structures Are Not Enough [0.03%]
人工智能在计算蛋白研究中的优势及展望未来挑战：单一结构研究不足以为继
Pradeep Bk,Shi-Jie Chen,Ruxandra Dima et al.
Pradeep Bk et al.
The ability to understand proteins and their behaviors has been drastically improved by major successes in structure prediction and the appearance of Large Protein Language Models. The speed with which Deep Learning and Artificial Intellige...
The central pore of HIV-1 capsomers promotes sustained stability of the viral capsid [0.03%]
HIV-1衣壳多聚体的中央孔道促进病毒衣壳的稳定性
Alex B Kleinpeter,Donna L Mallery,Anna Albecka et al.
Alex B Kleinpeter et al.
The HIV-1 capsid, which orchestrates several key post-entry events to facilitate infection, is composed of hexamers and pentamers (capsomers) of the capsid (CA) protein. The capsomers are arranged in a closed, conical structure - the capsid...
Aadrita Hazra,Bishajit Sarkar,Emma K Carlson et al.
Aadrita Hazra et al.
Inflammasomes are vital components of the innate immune system that sense invading pathogens and other danger signals. Upon activation, these cytosolic platforms induce pyroptotic cell death and IL-1 cytokine production. Inflammasome respon...
The β2αB loop determines NAD(P) cofactor specificity and kinetics in trypanosomal D-3-hydroxy-butyrate dehydrogenases [0.03%]
β2αB环决定棘原体D-3-羟基丁酸脱氢酶的NAD（P）辅因子特异性和动力学特征
Hideharu Hashimoto,Ian H Mawn,William Escobar-Arrilaga et al.
Hideharu Hashimoto et al.
Bacterial d-3-hydroxybutyrate dehydrogenases (HBDHs) catalyze the conversion between d-3-hydroxybutyrate and acetoacetate with NAD as the cofactor but not with NAD 2'-phosphate (NADP). However, HBDHs of the early-branched eukaryotic genus T...
Distinct Assembly Complexes facilitate cbb3-type Cytochrome Oxidase Maturation [0.03%]
独特的蛋白装配复合物促进cbb3型细胞色素氧化酶成熟
Kaiwei Shen,Yavuz Öztürk,Jorge Jimenez-Niebla et al.
Kaiwei Shen et al.
Cytochrome oxidase (Cox) assembly is inherently challenging because subunit associations need to be tightly coordinated with cofactor insertions. In mitochondria, this process relies on large assembly machineries, whereas bacterial Cox asse...
The Half-Life of a Mark: Dwell Time and the Missing Time Axis of the Epitranscriptome [0.03%]
甲基的半衰期——缺失的时间轴及其对表转录组的影响
Hidenori Tani
Hidenori Tani
The epitranscriptome has been mapped in extraordinary detail, and metabolic-labeling assays have begun to measure how fast modifications turn over at the population level - yet the per-molecule residence time of a mark, how long it remains ...
Rafaela Lacerda,Miguel Carvalho,Luísa Romão
Rafaela Lacerda
Nonsense-mediated decay (NMD) is a vital RNA surveillance mechanism in eukaryotic cells that ensures mRNA quality and regulates gene expression. NMD targets mRNAs with premature translation-termination codons to prevent the production of po...