Liquid-liquid phase separation modulates the structural heterogeneity of tau amyloid fibrils [0.03%]
液滴凝聚可调节tau蛋白淀粉样纤维的结构异质性
Ishtiyaq A Ganaie,Jayant B Udgaonkar
Ishtiyaq A Ganaie
The protein tau can undergo two types of phase transitions, amyloid fibrillar aggregation leading to neurodegenerative disease, as well as liquid-liquid phase separation (LLPS) leading to the formation of protein condensates. The link betwe...
Jiahao He,Yansheng Chen,Jinxi Wu et al.
Jiahao He et al.
The biological activities of many membrane proteins are pH-regulated, yet mapping their pH dependence experimentally is slow and expensive. In this work, we present MPKaDB (http://computbiophys.com /DeepKa/mpkadb), a comprehensive pKadataba...
PrePPI - Structure-based prediction of protein-protein interactomes and networks [0.03%]
基于结构的蛋白质相互作用预测及网络预测平台(PrePPI)
Caroline Velez,Aniket Naravane,Victor I Robila et al.
Caroline Velez et al.
PrePPI is a structure-based pipeline that predicts protein-protein interactions (PPIs) between two structured domains and between structured domains and short linear motifs (SLiMs) on a proteome-wide scale. Since the 2023 Computational Reso...
Active Site Assembly by SMG5 as a Mechanism for SMG6 Endonuclease Licencing in Nonsense-mediated mRNA Decay [0.03%]
SMG5活化位点组装机制在无义介导的mRNA降解中对SMG6内切酶的许可作用
Enes S Arpa,Michael Taschner,Mara De Matos et al.
Enes S Arpa et al.
Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic surveillance pathway that eliminates transcripts containing premature termination codons (PTCs). Substantial progress has been made in defining the transcript features that mark a...
Kate Magante,Candice M Armstrong,Mark Lee et al.
Kate Magante et al.
The acquisition of iron is critical for the survival and the virulence of numerous infectious pathogens, and most bacteria acquire ferrous iron (Fe2+) by utilizing the ferrous iron transport (Feo) system. FeoB is the main component of this ...
Structural, mechanistic and phylogenetic insights into a freshwater actinorhodopsin [0.03%]
结构、机制和系统发育视角下的淡水光应蛋白（actinorhodopsin）
Nadia Djabeur,Jean-Marc Jeckelmann,Nooraldeen Ayoub et al.
Nadia Djabeur et al.
Actinorhodopsins represent a unique subgroup of microbial rhodopsins, predominantly found in non-marine Actinobacteria and proposed to contribute to the global energy cycle. Despite their ecological significance, structural information on t...
Shirin Jahangirnejad,Jean-Philippe Côté,Daniel A Lafontaine
Shirin Jahangirnejad
Riboswitches offer a promising avenue as targets for the development of novel bacterial antibiotics. For this approach to work, it requires that target riboswitches control the expression of essential genes for bacterial survival. However, ...
Rising Stars: Molecular and functional diversity of the sensory nervous system [0.03%]
新兴神经系统感觉神经元的多样性和功能研究
Xinbo Ni,Wenwen Zeng
Xinbo Ni
Dr. Wenwen Zeng serves as a professor in the Institute for Immunology and School of Basic Medical Sciences at Tsinghua University. She received her B.Sc. degree in Tsinghua University and a Ph.D. degree in the University of Texas Southweste...
Cell Lines CoCoPUTs: A Database of Codon and Codon-pair Usage Frequencies in Cell Lines [0.03%]
细胞系中的密码子与密码子对使用频率数据库(CoCoPUTs)
Nigam Padhiar,Nathan Clement,Upendra Katneni et al.
Nigam Padhiar et al.
Cell lines are essential tools for studying biological mechanisms, advancing pre-clinical drug discovery and supporting biologics production. To further research in these fields, we introduce the Cell Lines CoCoPUTs (Codon and Codon Pair Us...
PERCEPTRON-PTMKB: A Web Server for Residue-Based Post-Translational Modification Analysis and Propensity Scoring [0.03%]
基于残基的蛋白质翻译后修饰分析和倾向性评分的网络服务器PERCEPTRON-PTMKB
Abdullah Bin Faiz,Muhammad Shoaib,Safee Ullah Chaudary
Abdullah Bin Faiz
The identification of post-translational modifications (PTMs) of protein residues is vital for understanding protein functions and their subsequent role in cellular processes. Researchers have collected substantial experimental data on PTMs...