The Liver-Enriched Long Non-Coding RNA FAM99A Suppresses Tumorigenesis through Negative Regulation of Protein Synthesis [0.03%]
肝脏丰富长链非编码RNA FAM99A通过抑制蛋白质合成为肿瘤形成按刹车作用
Nima Sarfaraz,Ranjit Kaur,Sky Harper et al.
Nima Sarfaraz et al.
Primary liver cancer represents a significant global health burden, with limited therapeutic options for advanced disease. Long non-coding RNAs (lncRNAs) are increasingly found to play crucial roles in hepatic biology and disease progressio...
Direct actin monomer delivery is a WASP-specific requirement for Arp2/3 complex activation [0.03%]
直接向肌动蛋白单体递送是激活Arp2/3复合物的WASP特异性要求
Sofia R Carlson,Brad J Nolen
Sofia R Carlson
WASP family proteins activate Arp2/3 complex to nucleate branched actin filaments in diverse cellular processes. To activate, WASP proteins recruit actin monomers to Arp2/3 complex through their conserved WASP homology 2 domains, but how th...
Electrolyte-amino acid interplay in the stability mechanisms of halophilic proteins [0.03%]
卤嗜性蛋白稳定机制中的电解质-氨基酸相互作用
Xiaoci Hu,Ana Vila Verde
Xiaoci Hu
Proteins of halophilic microorganisms thrive in high-salt environments. Compared to mesophilic proteins, they are enriched in acidic residues and small polar/apolar amino acids while being depleted in large hydrophobic residues, features th...
Alpha&ESMhFolds: an updated web server for the comparison, evaluation, and annotation of human AlphaFold2 and ESMFold models [0.03%]
Alpha&ESMhFolds：一个更新的网络服务器，用于比较、评估和注释人类AlphaFold2和ESMFold模型
Manfredi Matteo,Vazzana Gabriele,Castrense Savojardo et al.
Manfredi Matteo et al.
The human reference proteome is routinely modeled with predictive tools such as AlphaFold2 and ESMFold. The two methods, based on different procedures, can behave differently depending on the experimental information available for a protein...
ProteoCast: a web server to predict, validate, and interpret missense variant effects [0.03%]
预测、验证和解释错义变异效应的web服务器-ProteoCast
Marina Abakarova,Maria Inés Freiberger,Arnaud Liehrmann et al.
Marina Abakarova et al.
Understanding how mutations affect protein function remains critical yet challenging, particularly for variants in clinical databases lacking experimental characterisation and for intrinsically disordered regions. Current computational appr...
Multivalent AMOTL1 Engages NEDD4-1 and KIBRA through Distinct Cooperative Binding Mechanisms [0.03%]
多功能AMOTL1通过不同的协同结合机制与NEDD4-1和KIBRA相互作用
Amber Vogel,Matthew McWhorter,Ethiene Kwok et al.
Amber Vogel et al.
The Hippo signaling pathway regulates the homeostatic balance between cell growth and apoptosis through intricate networks of multivalent protein complexes. How multivalency modulates the assembly and stability of these protein complexes re...
ModelCIF update: Supporting Emerging Classes of Computational Macromolecular Models [0.03%]
模型CIF更新：支持新兴的计算大分子模型类别
Gerardo Tauriello,Yoriko Lill,Jacopo Sgrignani et al.
Gerardo Tauriello et al.
The recent development of highly accurate protein structure prediction tools has led to a rapid expansion in the scope of computational structural biology, enabling a much wider range of modelling studies than ever before. These new in sili...
HMRPred: A Machine Learning-Based Web Resource for Identification of Heavy Metal Resistance Proteins [0.03%]
基于机器学习的重金属抗性蛋白识别网络资源HMRPred
Sneha Murmu,Jaya Krishna,Himanshushekhar Chaurasia et al.
Sneha Murmu et al.
Heavy metal contamination poses a significant threat to environmental health, agriculture, and microbial ecosystems, necessitating the identification of molecular components that confer resistance. Heavy metal resistance (HMR) proteins enab...
Bo Yuan,Subhra Kanti Das,Weilin Wang et al.
Bo Yuan et al.
Linker histone H1 plays crucial roles in nucleosome compaction and chromatin condensation. The highly basic C-terminal domain (CTD) of H1 interacts strongly with DNA, a critical aspect of its contribution to H1 function. Despite its critica...
ACCU-RATES: A web tool for accurate enzyme kinetics and initial reaction rate measurements [0.03%]
准确的酶动力学和初始反应速率测定的网络工具ACCU-RATES
Maria Filipa Pinto,António Pombinho,Rita Reis et al.
Maria Filipa Pinto et al.
Accurate determination of initial reaction rates (v0) is essential for characterizing enzyme function, designing inhibitors, and modeling biological systems. Traditional methods rely on linear approximations valid for reaction phases diffic...