Beyond drug delivery: nanoparticles as active modulators of immunometabolism for treating inflammatory diseases [0.03%]
超越药物输送：纳米颗粒作为免疫代谢的活性调节剂用于治疗炎症性疾病
Hailing Wang,Ahequeli Gemingnuer,Yinan Wang et al.
Hailing Wang et al.
Immunometabolism is central to chronic inflammatory diseases, with metabolic reprogramming including dysregulated glycolysis, mitochondrial dysfunction, and excessive ROS production driving pathology in conditions like IBD, rheumatoid arthr...
Erythrocyte membrane-camouflaged doxorubicin nanoparticles for enhancing therapeutic efficacy in primary liver cancer [0.03%]
红细胞膜伪装的阿霉素纳米颗粒用于提高原发性肝癌治疗效果
Ting-Ting Hu,Ying Ding,Yi-Ren Yao et al.
Ting-Ting Hu et al.
Doxorubicin (DOX), an anthracycline antibiotic, stands as one of the most potent and clinically ubiquitous chemotherapeutic agents for cancer treatment. Despite advances in clinical supportive care, strategies to prevent DOX-induced toxicit...
Enhancing the Efficacy and Bioavailability of Isoxsuprine for the Treatment of Cardiotoxicity: In vitro and In vivo Studies [0.03%]
用于治疗心毒性异丙肾上腺素的体内和体外研究：增强其疗效和生物利用度
Asmaa M El-Kalaawy,Marwa H Elkarmalawy,Amr Gamal Fouad et al.
Asmaa M El-Kalaawy et al.
Isoxsuprine (ISX) is a blood flow-improving beta-adrenergic agonist that provides cardiotoxicity protection. However, the limited effectiveness of ISX can be attributed to a short half-life and low bioavailability. The focus of this study w...
Finasteride-Loaded Phospholipid-Bile Salt Mixed Micelles for Targeted Follicular Delivery in Androgenetic Alopecia [0.03%]
用于雄激素性脱发的富马松脂质-胆盐混合micelles囊泡递药系统研究
Mohammad Saleh Sadeghi,Naghmeh Jabarimani,Helia Behrouzfar et al.
Mohammad Saleh Sadeghi et al.
Androgenetic alopecia (AGA) is driven by elevated scalp dihydrotestosterone. Although oral Finasteride (FNS) is clinically effective, its long-term use is limited by sexual and psychological adverse effects. Topical delivery has the potenti...
Nanomedicine Strategies for Mitigating Cancer Therapy-Related Cardiovascular Toxicity [0.03%]
纳米医学策略缓解癌症治疗相关的心血管毒性
QuZhe Lu,ZhaoWu Li,Zhi Hu et al.
QuZhe Lu et al.
Cancer therapy-induced cardiotoxicity represents a serious clinical complication driven by oxidative injury, topoisomerase IIβ-mediated DNA damage, endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and sustained inflammatory si...
Potential Therapeutic Benefits of Lutein-loaded Hydrogel in Diabetic-Induced Dermal Wound Healing [0.03%]
叶黄素载药水凝胶在糖尿病皮肤创面修复中的潜在治疗作用
Zuha Rahman,Vidhu Aeri
Zuha Rahman
Research on wound-healing agents is a growing area in modern biomedical sciences, and oxidative stress plays a significant role in the challenges of chronic wound healing. These challenges include dry dressings that lack functionality and c...
From Sound Waves to Systemic Cure: Transformative Nanotechnology-Driven Sonodynamic Strategies in Liver Cancer [0.03%]
从声波到全身治疗：纳米技术驱动的声动力学策略在肝癌中的变革性应用
Drashti Shukla,Jigal Hirawla,Devesh U Kapoor et al.
Drashti Shukla et al.
Liver cancer is the third leading cause of cancer-related deaths worldwide, with hepatocellular carcinoma (HCC) accounting for nearly 75-85% of total cases. As per recent global cancer estimates, over 900,000 new cases and more than 800,000...
Natural triterpenoid glycosides, astragaloside II and astragaloside IV resensitize multidrug-resistant cancer via interfering ATPase activity and inducing apoptosis in vitro and in vivo [0.03%]
天然三萜苷astragaloside II和astragaloside IV通过干扰ATP酶活性和诱导凋亡体内外逆转多药耐药癌症
Ying-Tzu Chang,Po-Yu Chien,Ching-Hui Su et al.
Ying-Tzu Chang et al.
Chemoresistance, often associated with multidrug resistance (MDR), is a significant challenge in cancer treatment. P-glycoprotein (P-gp) is overexpressed in various MDR cancers and is a drug efflux transporter of chemotherapeutics. Astragal...
Alendronate-conjugated liposome for targeting of osteoblastic prostate cancer: Evaluation of binding to bone matrix and in vivo targeting in a mouse model [0.03%]
一种用于靶向成骨性前列腺癌的阿伦膦酸偶联脂质体：结合到骨基质和在小鼠模型中的靶向作用的评价
Kitz Paul D Marco,Jossana A Damasco,Guoyu Yu et al.
Kitz Paul D Marco et al.
Prostate cancer bone metastases are predominantly osteoblastic, placing them in a unique position for bone-targeted drug delivery. Bone-targeted nanoparticles may be able to accumulate in aberrant bone formation inside these osteoblastic tu...
Pravastatin-Loaded Nanostructured Lipid Carriers: Formulation Optimization and In-Vivo Assessment for Antihyperlipidaemic Effect in Rats [0.03%]
载普拉伐他丁的纳米结构脂质载体制剂优化及其抗高脂血症效应的研究
Anjali More,Ameeduzzafar Zafar,Omar Awad Alsaidan et al.
Anjali More et al.
This study aimed to create nanostructured lipid carriers (NLCs) loaded with pravastatin to improve its long-term anti-hyperlipidemic effects. Preformulation research was conducted. High-shear homogenization and ultrasonication were used to ...