Multi-pathway therapeutics in colorectal cancer: Targeting EMT, CSCs, and non-apoptotic cell death for drug resistance reversal [0.03%]
逆转药物耐药性的结直肠癌多通路治疗：靶向EMT、CSC和非凋亡性细胞死亡
Jiegang Hu,Zhiwei Tang,Narasimha M Beeraka et al.
Jiegang Hu et al.
Colorectal cancer (CRC) is a leading global malignancy, with therapeutic outcomes hampered by chemoresistance from epithelial-mesenchymal transition (EMT), colorectal cancer stem cells (CR-CSCs), and apoptosis evasion. Evidence highlights t...
Targeting Osteoporosis: Rutin-Loaded Proniosomes and Their Role in OPG/RANKL Modulation in Ovariectomized Rats [0.03%]
靶向治疗骨质疏松： rutin载药前尼奥ソーム及其在卵巢切除大鼠中对OPG / RANKL调节的作用
Abeer Salama,Amira Mohamed Mohsen,Asmaa Badawy Darwish
Abeer Salama
The current study aimed to investigate effect of Rutin loaded proniosomes on ovariectomized female rats for the treatment of osteoporosis. Rutin-loaded proniosomes (Rutin-PNs) were developed using coacervation phase separation method. The d...
ICAM-1 Targeting of Nanocarriers in a Human Blood-Brain-Barrier-on-a-Chip Complements In Vivo Brain Delivery Observations [0.03%]
人血脑屏障芯片中的纳米载体ICAM-1靶向互补体内脑递送观测结果
Marco Vigo,Sujey Palma-Florez,Rita Grimalt et al.
Marco Vigo et al.
Targeting therapeutic nanocarriers (NCs) to endothelial receptors favors transport across the blood-brain barrier (BBB), a main obstacle to access the brain. While these strategies compel validation in animals, quantitative sub-cellular res...
Mitigating Doxorubicin-Induced Toxicity in Breast Cancer Treatment with In Situ pH-Sensitive Carvedilol-loaded Transbilosomes: In Vitro and In Vivo Characterization [0.03%]
通过原位pH响应的Transbiosome递送卡维地洛减轻乳腺癌治疗中的多柔比星毒性：体外及体内研究
Tamer Mohamed Mahmoud,Mohammed Ayad Alboreadi,Fatma I Abo El-Ela et al.
Tamer Mohamed Mahmoud et al.
Doxorubicin (DRC) is widely used as a breast cancer treatment. However, its use is limited due to cardio, hepatic, and renal toxicities. Carvedilol (CVL) has emerged as a potential protective agent against DRC-induced toxicity (DIT). Despit...
Eco-Friendly Synthesis of Novel Enaminonitrile Pyridine Derivatives: 131I-Radiosynthesis, Anticancer Investigation and In-Vivo Study in Tumour Bearing Mice [0.03%]
新型烯胺腈吡啶衍生物的绿色合成：131I标记放射合成、抗肿瘤研究及荷瘤小鼠体内实验
Adli A Selim,Basma M Essa,Safaa S Shaban et al.
Adli A Selim et al.
Purpose: This study aimed to develop sustainable synthetic routes for novel enaminonitrile pyridine derivatives and evaluate a lead compound's potential as a dual-action theranostic agent for oncology, combining targeted ...
Exploring Chitosan/Clay Microparticles Enriched with Fenugreek Extract as a Potential Treatment Strategy for Infectious Diarrhea: Preclinical Investigation [0.03%]
富含香菜提取物的壳聚糖/粘土微粒作为感染性腹泻潜在治疗策略的临床前研究探索
Yan Cheng
Yan Cheng
The objective of this study was to develop a new delivery system, Fenugreek extract loaded into chitosan/clay particles, to treat bacterial diarrhea in a rat model. Microstructure studies, cell viability assay, release assay, antibacterial ...
Amorphous calcium phosphate tagged benzimidazole derivative MR10 nanoconjugate mitigates corticosteroid induced secondary osteoporosis in vivo [0.03%]
无定形钙磷酸盐标记的苯并咪唑衍生物MR10纳米缀合物可减轻糖皮质激素引起的继发性骨质疏松症
Sanjay Gopi,S Prethiba,S Madesh et al.
Sanjay Gopi et al.
Corticosteroid-induced osteoporosis leads to accelerated bone loss with associated oxidative stress, necessitating novel targeted therapeutic approaches. This work evaluates the protective efficacy of Amorphous Calcium Phosphate-tagged Benz...
Polysaccharide-Coated mPEG-PLA Nanoparticles Enhance Thymoquinone Delivery and Therapeutic Efficacy against Colorectal Cancer [0.03%]
表面活性多糖的mPEG-PLA纳米颗粒增强化橘芹生物碱的递送和抗结直肠癌功效
Shaheer Hasan Khan,Hina Younus,Masood Alam Khan
Shaheer Hasan Khan
Colorectal cancer (CRC) remains a major therapeutic challenge due to systemic toxicity and poor tumor selectivity of conventional treatments. Thymoquinone (TQ), a natural anticancer compound, faces limited clinical utility because of poor s...
Fabrication of Crosslinker-Free Chitosan-HPMC Hydrogel for Implant Coating: A new Approach for the Treatment of Osteomyelitis [0.03%]
一种治疗骨髓炎的新方法：用于医疗器械表面防感染涂层的无交联剂壳聚糖-羟丙基甲基纤维素水凝胶的制备
Mohammad Zahraei,Elahe Aghazadeh,Farid Abedin Dorkoosh et al.
Mohammad Zahraei et al.
Treatment of osteomyelitis is challenging because the systemic circulation often cannot deliver sufficient concentrations of antibiotics directly to the site of infection. The aim of this study was to fabricate a crosslinker free hydrogel c...
Mizolastine-loaded Spanlastics for treatment of Atopic Dermatitis: Immunomodulatory approach for management of inflammation [0.03%]
用于治疗特应性皮炎的 Mizolastine 荷载 Spanlastics 的免疫调节抗炎方法
Marwa G Elnaggar,Aml I Mekkawy,Amira F Taha et al.
Marwa G Elnaggar et al.
Atopic dermatitis (AD) is the most widespread chronic inflammatory skin disease characterized by impaired skin barrier, higher immunoglobulin E (IgE)-mediated sensitization, and pronounced inflammatory and immune activity. In this study, mi...