Finasteride-Loaded Phospholipid-Bile Salt Mixed Micelles for Targeted Follicular Delivery in Androgenetic Alopecia [0.03%]
用于雄激素性脱发的富马松脂质-胆盐混合micelles囊泡递药系统研究
Mohammad Saleh Sadeghi,Naghmeh Jabarimani,Helia Behrouzfar et al.
Mohammad Saleh Sadeghi et al.
Androgenetic alopecia (AGA) is driven by elevated scalp dihydrotestosterone. Although oral Finasteride (FNS) is clinically effective, its long-term use is limited by sexual and psychological adverse effects. Topical delivery has the potenti...
Nanomedicine Strategies for Mitigating Cancer Therapy-Related Cardiovascular Toxicity [0.03%]
纳米医学策略缓解癌症治疗相关的心血管毒性
QuZhe Lu,ZhaoWu Li,Zhi Hu et al.
QuZhe Lu et al.
Cancer therapy-induced cardiotoxicity represents a serious clinical complication driven by oxidative injury, topoisomerase IIβ-mediated DNA damage, endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and sustained inflammatory si...
Potential Therapeutic Benefits of Lutein-loaded Hydrogel in Diabetic-Induced Dermal Wound Healing [0.03%]
叶黄素载药水凝胶在糖尿病皮肤创面修复中的潜在治疗作用
Zuha Rahman,Vidhu Aeri
Zuha Rahman
Research on wound-healing agents is a growing area in modern biomedical sciences, and oxidative stress plays a significant role in the challenges of chronic wound healing. These challenges include dry dressings that lack functionality and c...
From Sound Waves to Systemic Cure: Transformative Nanotechnology-Driven Sonodynamic Strategies in Liver Cancer [0.03%]
从声波到全身治疗：纳米技术驱动的声动力学策略在肝癌中的变革性应用
Drashti Shukla,Jigal Hirawla,Devesh U Kapoor et al.
Drashti Shukla et al.
Liver cancer is the third leading cause of cancer-related deaths worldwide, with hepatocellular carcinoma (HCC) accounting for nearly 75-85% of total cases. As per recent global cancer estimates, over 900,000 new cases and more than 800,000...
Natural triterpenoid glycosides, astragaloside II and astragaloside IV resensitize multidrug-resistant cancer via interfering ATPase activity and inducing apoptosis in vitro and in vivo [0.03%]
天然三萜苷astragaloside II和astragaloside IV通过干扰ATP酶活性和诱导凋亡体内外逆转多药耐药癌症
Ying-Tzu Chang,Po-Yu Chien,Ching-Hui Su et al.
Ying-Tzu Chang et al.
Chemoresistance, often associated with multidrug resistance (MDR), is a significant challenge in cancer treatment. P-glycoprotein (P-gp) is overexpressed in various MDR cancers and is a drug efflux transporter of chemotherapeutics. Astragal...
Alendronate-conjugated liposome for targeting of osteoblastic prostate cancer: Evaluation of binding to bone matrix and in vivo targeting in a mouse model [0.03%]
一种用于靶向成骨性前列腺癌的阿伦膦酸偶联脂质体：结合到骨基质和在小鼠模型中的靶向作用的评价
Kitz Paul D Marco,Jossana A Damasco,Guoyu Yu et al.
Kitz Paul D Marco et al.
Prostate cancer bone metastases are predominantly osteoblastic, placing them in a unique position for bone-targeted drug delivery. Bone-targeted nanoparticles may be able to accumulate in aberrant bone formation inside these osteoblastic tu...
Pravastatin-Loaded Nanostructured Lipid Carriers: Formulation Optimization and In-Vivo Assessment for Antihyperlipidaemic Effect in Rats [0.03%]
载普拉伐他丁的纳米结构脂质载体制剂优化及其抗高脂血症效应的研究
Anjali More,Ameeduzzafar Zafar,Omar Awad Alsaidan et al.
Anjali More et al.
This study aimed to create nanostructured lipid carriers (NLCs) loaded with pravastatin to improve its long-term anti-hyperlipidemic effects. Preformulation research was conducted. High-shear homogenization and ultrasonication were used to ...
Lipid-based nanocarriers coupled with CO2 laser-mediated drug delivery enhance skin penetration and hair follicle targeting [0.03%]
基于脂质的纳米递送系统结合二氧化碳激光介导药物传输提高皮肤渗透性和毛囊定位性
Woan-Ruoh Lee,Wei-Ling Chou,Chien-Yu Hsiao et al.
Woan-Ruoh Lee et al.
The topical administration of hydrophilic drugs such as minoxidil and minocycline for alopecia and acne treatments remains unsatisfactory due to limited skin absorption and follicular uptake. The combination of physical and chemical enhance...
Nanocarrier based Topical Gel of Clofazimine: Advanced Therapeutic Strategy for the Treatment of Leprosy [0.03%]
用于治疗麻风病的氯法齐明纳米载体基外用凝胶：先进的治疗策略
Shailesh Chalikwar,Tanaya Dhole,Pankaj Jain et al.
Shailesh Chalikwar et al.
This study aims to formulate Clofazimine (CLOF)-loaded nanostructured lipid carriers (NLCs) for transdermal application, thereby improving the overall efficacy of the drug. NLCs loaded with clofazimine were developed using biocompatible lip...
Preparation and Evaluation of Elastic Provesicular Chrysin Carriers: A Targeted Therapeutic Strategy for Mitigating Ulcerative Colitis [0.03%]
弹性胶束状黄酮载体的制备及评价：治疗溃疡性结肠炎的靶向策略
Abeer Salama,Marwa Anwar Wagdi,Amany A El-Fadaly et al.
Abeer Salama et al.
Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel syndrome characterized by inflammation and oxidative deterioration. Our study aimed to investigate provesicular formulations (Pro) as a novel carrier for chrysin (CR) to enh...