Dual-responsive hydrogel-coated nanoclusters for combined magnetic hyperthermia and drug delivery: a comprehensive in vitro and in vivo toxicity profiling [0.03%]
一种用于联合磁热疗和药物递送的双响应性水凝胶涂层纳米聚集体：全面的体内外毒性分析
Regan Charles R,Subhasis Sarangi,Aranganathan V
Regan Charles R
Cancer therapy demands smarter, more targeted strategies that minimise healthy tissue damage while maximising therapeutic efficacy. This study introduces Hy-Si-IONC, a dual heat- and pH-responsive hydrogel-coated magnetic nanocluster, engin...
A Novel Te-Ethosomes-loaded Thermosensitive Gel for Enhanced Transdermal Delivery and Melasma Therapy [0.03%]
一种新型载Te-_ethosomes热敏凝胶用于增强经皮递送和黄褐斑治疗的研究
Qian Zhu,Wei Zhang,Junmo Yang et al.
Qian Zhu et al.
The therapeutic potential of tectoridin for melasma treatment is limited by its poor aqueous solubility. To address this limitation, we developed tectoridin-loaded ethosomes using the film dispersion method, and optimized the formulation vi...
Galactosylated chitosan-functionalized liposome for targeted delivery of Coreopsis tinctoria flavonoids: Protective effect in acute liver injury [0.03%]
半乳糖化壳聚糖功能化脂质体靶向递送/coreopsis tinctoriaflavonoids的作用及机制研究
Juan Du,Xinmei Chen
Juan Du
Acute liver injury (ALI) is a syndrome characterized by rapid deterioration of liver function, rapid progression, and high mortality. In this study, a liver-targeted drug delivery system, galactosylated chitosan modified Coreopsis tinctoria...
Tubulin as a Well-Established Yet Underexploited Target: New Opportunities for Drugs Repurposing? [0.03%]
β-管蛋白是一个老靶点但尚待开发：再利用药物的新机遇？
Philipp O Tsvetkov
Philipp O Tsvetkov
Drug repurposing can accelerate oncology translation by leveraging approved compounds with known pharmacology; success depends on a plausible mechanism for the new indication. The microtubule cytoskeleton is a validated anticancer target, y...
Physcion-Loaded, Folic Acid-Conjugated DSPE-PEG Liposomes for Targeted Therapy of Ulcerative Colitis [0.03%]
用于溃疡性结肠炎靶向治疗的加载紫胶素的叶酸偶联DSPE-PEG脂质体
Zhenhua Guan,Yi Xu,Xuyang Liang et al.
Zhenhua Guan et al.
Conventional therapeutic agents for ulcerative colitis (UC) exhibit limited efficacy and toxic side effects. Although the natural compound physcion (PHY) demonstrates multi-target anti-inflammatory potential, its clinical application is con...
Enzyme-responsive 2-dimensional nanomaterials for targeted breast cancer treatment [0.03%]
针对乳腺癌的酶响应二维纳米材料治疗
Lavanya N,Vijayabharathi S,Mohamed Nawfal Ibraheam A M et al.
Lavanya N et al.
Breast cancer is still one of the most prevalent causes of cancer deaths globally. This is because systemic toxicity, multidrug resistance and poor tumor selectivity typically make treatment less effective. Traditional drug delivery methods...
Integrating antibody-drug conjugates, multispecific antibodies, targeted protein degradation and nanomedicine in precision oncology [0.03%]
精准肿瘤学中抗体药物偶联物、多特异性抗体、靶向蛋白降解和纳米医学的融合
Imran Ali,Mir Faiza,Arshad Mehmood et al.
Imran Ali et al.
Molecular engineering, chemical biology and translational oncology have transformed the landscape of targeted cancer therapies. Antibody-drug conjugates (ADCs) have advanced into clinically validated platforms that combine antigen-specific ...
Nanomaterials for Subcellular Organelle Targeting: Unlocking New Avenues for Enhanced Therapeutic Effectiveness [0.03%]
用于亚细胞器靶向的纳米材料：增强治疗效果的新途径
Kiarash Solouki,Muhammad Sohail
Kiarash Solouki
Subcellular organelle targeting is changing the way nanomedicine is designed, moving the field beyond simple cellular entry toward more precise intracellular localization, controlled cargo release, and functional activity within disease-rel...
Eletriptan HBr Loaded Solid Lipid Nanoparticle Integrated Microneedles: A Targeted and Minimally Invasive Approach for Migraine Management [0.03%]
一种新型布给药系统：用于偏头痛管理的固态脂质纳米粒加载电阿米三嗪氢溴酸盐集成微针方法
Ankith Nallapeta Amaranatha,Sateesha Shivally Boregowda,Shivanand Kalyanappa Mutta et al.
Ankith Nallapeta Amaranatha et al.
Eletriptan hydrobromide (EHBr) exhibits poor oral bioavailability due to extensive first-pass metabolism by CYP3A4 and P-glycoprotein mediated efflux at the blood brain barrier. Therefore, this study was conceptualized to encapsulate EHBr i...
Carbonic anhydrase modulation in the tumor microenvironment: synergistic pathways with oncolytic viruses in gastrointestinal malignancies [0.03%]
肿瘤微环境中焦磷酸酶的调节：溶瘤病毒在胃肠道恶性肿瘤中的协同途径
Reza Zolfaghari Emameh
Reza Zolfaghari Emameh
Gastrointestinal (GI) malignancies are leading causes of global cancer mortality, with advanced stages showing pronounced therapeutic resistance. A key driver of this aggression is the immunosuppressive and acidic tumor microenvironment (TM...