Paclitaxel-loaded Bone Acellular Extracellular Matrix Injectable Hydrogel for Osteosarcoma Treatment [0.03%]
载紫杉醇的骨无细胞基质注射型水凝胶用于治疗骨肉瘤
He Chen,Kaili Ye,Chaonan Zhang
He Chen
A novel local chemotherapy delivery system was developed to improve the therapeutic efficacy of paclitaxel (PTX) for osteosarcoma while reducing systemic toxicity, low bioavailability, and tumor recurrence. PTX-loaded polylactic-co-glycolic...
Development of venlafaxine hydrochloride nasal thermosensitive in-situ gel with P407/P188: enhanced bioavailability and antidepressant effects in depressive rats [0.03%]
以P407/P188为促渗剂的盐酸文拉法辛鼻用热敏凝胶给药系统的研究及其在抑郁大鼠模型中的抗抑郁作用
Yili Wu,Yujia Zhang,Dong Li et al.
Yili Wu et al.
Objective: To develop and optimise a VEN nasal thermosensitive in-situ gel for reducing the first-pass effect and enhancing bioavailability. Methods: ...
Targeted delivery of Naringenin-enriched mannosylated niosomal nanogel for effective therapy of skin cancer [0.03%]
一种用于皮肤癌有效治疗的富萘酚原儿茶酸曼醇化非离子胶束囊泡纳米凝胶的靶向传递系统
Nikita Verma,Swarnlata Saraf,Soniya Sarthi et al.
Nikita Verma et al.
Skin cancer is caused by excessive UVR exposure, which poses a serious health risk. The use of phytoconstituents as medicaments for the management of various diseases has been trending in recent years due to their fewer adverse effects than...
Advanced co-delivery nanocarriers to overcome drug resistance in breast cancer: carrier-mediated synergistic treatment by chemotherapy and gene therapy [0.03%]
用于克服乳腺癌耐药性的协同给药纳米载体：药物和基因治疗的载体介导的协同治疗
Jiale Yao,Jia Ju,Zedong Cai et al.
Jiale Yao et al.
Chemoresistance is a primary factor contributing to chemotherapy failure in breast cancer. Combining chemotherapeutic agents with nucleic acids that interfere with drug resistance-related genes can effectively overcome chemoresistance in br...
Therapeutic potential of mesenchymal stem cells-derived exosomes loaded with elemental or nano selenium on diabetic nephropathy [0.03%]
间充质干细胞外泌体递送元素硒或纳米硒治疗糖尿病肾病的潜力
Fatema Suliman Alatawi,Lashin S Ali,Khalid Elfaki Ibrahim et al.
Fatema Suliman Alatawi et al.
Endocrinologists and nephrologists continually seek new therapeutic approaches for diabetic nephropathy (DN). Lately, mesenchymal stem cell (MSC)-derived exosomes (MSC-EXs) have been applied as natural carriers for targeted drug delivery. T...
Nanomedicines for neurodegenerative ageing: nasal delivery innovations for Alzheimer's and Parkinson's disease [0.03%]
针对阿尔茨海默病和帕金森病的鼻用给药纳米药物创新
Rajshekher Upadhyay,Ayush Jain,Trivedi Karthik et al.
Rajshekher Upadhyay et al.
Alzheimer's disease and Parkinson's disease are progressive, age-related neurodegenerative disorders with increasing global prevalence, yet their treatment remains challenging despite the availability of multiple therapeutic agents. Convent...
Biased agonists for the treatment of type 2 diabetes and obesity: A novel pharmacological paradigm edging closer to clinical reality? [0.03%]
偏向性激动剂治疗2型糖尿病和肥胖：即将成为临床现实的新型药理学模式？
Ibrahim E Hashem,Baha H Abuajameia,Saghir Akhtar
Ibrahim E Hashem
Potential role of PVP/poloxamer 407 nanofibers loaded with resveratrol nanocrystals in skin cancer therapy [0.03%]
负载白藜芦醇纳米晶体的PVP/poloxamer 407纳米纤维在皮肤癌治疗中的潜在作用
Mahmoud A Elgewelly,Soha M Elmasry,Maged Wasfy Helmy et al.
Mahmoud A Elgewelly et al.
This work focused on producing resveratrol nanocrystals using a high-pressure, high-speed basic homogeniser to improve resveratrol's aqueous solubility, and subsequently electrospinning them into novel polyvinylpyrrolidone/poloxamer 407 nan...
Curcumin suppresses pancreatic cancer progression and glycolysis by modulating the circ_0001535/miR-126-5p/HIPK2 axis [0.03%]
姜黄素通过调节circ_0001535/miR-126-5p/HIPK2轴抑制胰腺癌进展和糖酵解
Luoluo Wang,Xiang Wu,Yi Ruan et al.
Luoluo Wang et al.
Although curcumin exerts anticancer effects in pancreatic cancer (PC) through various molecular pathways, its regulatory mechanisms mediated by non-coding RNA networks remain incompletely understood. This study sought to elucidate its funct...
In-situ gel systems for periodontitis: advances in localized drug delivery and regenerative therapy [0.03%]
用于牙周炎的原位凝胶系统：局部药物递送和再生疗法的研究进展
Afrasim Moin,Sateesha Shivally Boregowda,Ranjitha S et al.
Afrasim Moin et al.
Periodontitis is a chronic inflammatory condition initiated by pathogenic microbial biofilms and exacerbated by host immune responses, leading to progressive connective tissue, alveolar bone destruction and eventual tooth loss. Conventional...