Kai Chen,Xiongyi Huang,Shuo-Qing Zhang et al.
Kai Chen et al.
Previous work has demonstrated that variants of a heme protein, Rhodothermus marinus cytochrome c (Rma cyt c), catalyze abiological carbene boron-hydrogen (B-H) bond insertion with high efficiency and selectivity. Here we investigated this ...
A Protocol for Direct Stereospecific Amination of Primary, Secondary, and Tertiary Alkylboronic Esters [0.03%]
用于 primary、secondary 和 tertiary 仲基硼酸酯直接立体专一性氨化的协议
Emma K Edelstein,Andrea C Grote,Maximilian D Palkowitz et al.
Emma K Edelstein et al.
The direct, stereospecific amination of alkylboronic and borinic esters can be conducted by treatment of the organoboron compound with methoxyamine and potassium tert-butoxide. In addition to being stereospecific, this process also enables ...
"It's a (Kinetic) Trap!" - Selectively Differentiating Allylic Azide Isomers [0.03%]
“是（动力学）陷阱！”——选择性区分 allylic 氨基叠氮异构体
Joseph J Topczewski,Matthew R Porter
Joseph J Topczewski
Allylic azides are known to undergo the Winstein rearrangement and are often isolated as an equilibrating mixture of isomers. While this process has been known for almost 60 years, very few synthetic applications of this process have been r...
Jacob R Ludwig,Corinna S Schindler
Jacob R Ludwig
Olefin-olefin metathesis has led to important advances in diverse fields of research, including synthetic chemistry, materials science and chemical biology. The corresponding carbonyl-olefin metathesis also enables direct carbon-carbon bond...
Facile Synthesis of 3-Amido-Dienynes via a Tandem α-Propargylation-Isomerization of Chiral Allenamides and their Applications in Diels-Alder Cycloadditions [0.03%]
通过手性烯氨的串联α-炔丙基化-异构化反应合成3-酰胺茋化合物及其在狄尔斯-阿尔德环加成中的应用
Zhi-Xiong Ma,Li-Chao Fang,Richard P Hsung
Zhi-Xiong Ma
A series of de novo 3-amido-dienynes was synthesized via tandem α-propargylation-isomerization of chiral allenamides with moderate E/Z ratio. Reactivities of E-and Z-isomers were examined. ...
Investigating the Enantiodetermining Step of a Chiral Lewis Base Catalyzed Bromocycloetherification of Privileged Alkenes [0.03%]
优势烯烃的溴环醚化反应中手性Lewis碱催化决速步的探究
Dietrich Böse,Scott E Denmark
Dietrich Böse
The development of catalytic, enantioselective halofunctionalizations of unactivated alkenes has made significant progress in recent years. However, the identification of generally applicable catalysts for wide range of substrates has yet t...
Unexpected Rearrangement of 2-Bromoaniline under Biphasic Alkylation Conditions [0.03%]
二溴苯胺在两相烷基化条件下的意外重排反应
Scott J Barraza,Scott E Denmark
Scott J Barraza
Alkylation of 2-bromoaniline with benzyl bromide under ostensibly basic N-alkylation conditions resulted in migration of bromine from the 2- to the 4-aryl position. Herein we report our studies to elucidate the mechanism of this rearrangeme...
Understanding Site Selectivity in the Palladium-Catalyzed Cross-Coupling of Allenylsilanolates [0.03%]
探究亚烯基硅酸酯与钯催化交叉偶联的位点选择性理解
Scott E Denmark,Andrea Ambrosi
Scott E Denmark
Allenylsilanolates can undergo cross-coupling at the α- or γ-terminus, and site selectivity appears to be determined by the intrinsic transmetalation mechanism. Fine-tuning of concentration, nucleophilicity, and steric bulk of the silanol...
Unnatural Amino Acid Derivatives through Click Chemistry: Synthesis of Triazolylalanine Analogues [0.03%]
点击化学合成的非天然氨基酸衍生物：三氮唑丙氨酸类似物的合成
Pravin C Patil,Frederick A Luzzio
Pravin C Patil
A novel tert-butyl 2-(1-oxoisolndolin-2-yl)acetate derivative is selectively alkylated with propargyl bromide in the presence of lithium hexamethyldisilazide. After removal of the tert-butyl protecting group, the resulting N-isoindolinyl (e...
A Photochemical Two-Step Formal [5+2] Cycloaddition: A Condensation/Ring-Expansion Approach to Substituted Azepanes [0.03%]
光化学两步[5+2]环加成反应：合成取代氮杂庚烷的缩合/扩环策略
Scott M Thullen,David M Rubush,Tomislav Rovis
Scott M Thullen
Seven-membered nitrogen-containing heterocycles are considerably underrepresented in the literature compared to their five- and six-membered analogues. Herein, we report a relatively understudied photochemical rearrangement of N-vinylpyrrol...