Inverting the Conventional Site Selectivity of Cross-Coupling of 2,4-Dichloropyrimidines [0.03%]
2,4-二氯嘧啶交叉偶联的非传统位点选择性 inversion 研究
Oliver D Jackson,Sharon R Neufeldt
Oliver D Jackson
Cross-coupling and nucleophilic aromatic substitution reactions of 2,4-dihalopyrimidines generally favor reaction at the C4 site, especially in the absence of other substituents on the pyrimidine ring. Here we review our recent discovery of...
Enzymatic Peroxidation in the Chemoenzymatic Synthesis of 13-Oxoverruculogen [0.03%]
化学酶法合成13-氧紫草酮中的酶促氧化反应
Brandon Singh,Chi P Ting
Brandon Singh
Verruculogens are fumitremorgin alkaloids that contain an eight-membered endoperoxide ring. Due to their unusual structure and bioactivity, there has been much interest in these natural products since their discovery over forty years ago. S...
Synthesis and evaluation of N-arylsulfonylated succinimides as activity-based probes [0.03%]
N-芳基磺酰氨基甲酸酯类衍生物作为活性谱探针的合成及评价研究
Jo Chvatal,Dat T Nguyen,Alexondra S Xie et al.
Jo Chvatal et al.
Activity-based protein profiling (ABPP) technology has served as a powerful platform for studying proteins for more than two decades. However, the further growth of this field depends on the development of new probe structures to expand the...
Julius Semenya,Yuanjie Yang,Elias Picazo
Julius Semenya
Metal-catalyzed cross-coupling reactions have transformed molecular synthesis. Although metal-catalyzed reactions have been used for cross-electrophile coupling reactions, they remain challenging due to homodimer formation. Recently, our gr...
Development of a Triethylborane Mediated Giese Cyclization/Aldol Reaction Cascade for the Total Synthesis of Ganoapplanin [0.03%]
发展一种三乙基硼烷介导的吉塞环化/ aldol反应级联用于Ganoapplanin的全合成
Nicolas Müller,Ondřej Kováč,Alexander Rode et al.
Nicolas Müller et al.
We present our synthetic endeavors towards the Ganoderma meroterpenoid ganoapplanin. This natural product was isolated from a Ganoderma fungus in 2016 and was found to be an inhibitor for T-type voltage-gated calcium channels. Our synthetic...
Iron-Catalyzed Stereoselective Nitrogen Atom Transfer for 1,2- cis-Selective Glycosylation [0.03%]
铁催化立体选择性氮原子转移在1,2-顺式选择性糖基化中的应用
Hao Xu,Dakang Zhang,Zixiang Jiang et al.
Hao Xu et al.
This account highlights an iron-catalyzed exclusively 1,2-cis-selective glycosylation method for aminoglycoside synthesis. This selective nitrogen atom transfer reaction is effective for a broad range of glycosyl donors and acceptors, and i...
Asymmetric Isochalcogenourea-Catalyzed Synthesis of 3,4-Dihydropyrans via (4+2)-Cycloadditions of Ethyl But-3-ynoate with Michael Acceptors [0.03%]
异硫脲催化的乙基丁炔酸酯与迈克尔受体的(4+2)环加成反应合成3,4-二氢吡喃类化合物
Mario Hofer,Magdalena Piringer,Anna Scheucher et al.
Mario Hofer et al.
We herein report the use of ethyl but-3-ynoate as a C2 building block for asymmetric (4+2)-heterocycloadditions with various Michael acceptors. Upon using chiral isochalcogenoureas as Lewis base catalysts, these reactions can be carried out...
A Hammett Study of Clostridium acetobutylicum Alcohol Dehydrogenase (CaADH): An Enzyme with Remarkable Substrate Promiscuity and Utility for Organic Synthesis [0.03%]
应用汉密尔顿研究丁酸梭菌醇脱氢酶（CaADH）：一种具有独特底物普适性和有机合成实用价值的酶
Gaurav P Kudalkar,Virendra K Tiwari,Joshua D Lee et al.
Gaurav P Kudalkar et al.
Described is a physical organic study of the reduction of three sets of carbonyl compounds by the NADPH-dependent enzyme Clostridium acetobutylicum alcohol dehydrogenase (CaADH). Previous studies in our group showed this enzyme to display b...
Acetal Substitution Reactions: Stereoelectronic Effects, Conformational Analysis, Reactivity vs. Selectivity, and Neighboring-Group Participation [0.03%]
缩醛取代反应：立体轨道效应、构象分析、活性与选择性及邻基参与作用
Yuge Chun,Khoi B Luu,K A Woerpel
Yuge Chun
Acetal substitution reactions can proceed by a number of mechanisms, but oxocarbenium ion intermediates are involved in many of these reactions. Our research has focused on understanding the conformational preferences, structures, and react...
Erin E Plasek,Brylon N Denman,Courtney C Roberts
Erin E Plasek
The synthetic potential of unsymmetrically substituted aryne intermediates is significantly hindered by regioselectivity issues. Current methods for inducing regioselectivity all rely on substrate control and are focused on non-metallated a...