Unnatural Amino Acid Derivatives through Click Chemistry: Synthesis of Triazolylalanine Analogues
{{output}}
A novel tert-butyl 2-(1-oxoisolndolin-2-yl)acetate derivative is selectively alkylated with propargyl bromide in the presence of lithium hexamethyldisilazide. After removal of the tert-butyl protecting group, the resulting N-isoindolinyl (ethynylalanine) deriv... ...
