Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area [0.03%]
通过抑制中脑腹侧被盖区3α，5α-血清素生成来减轻大鼠行为性静止期的探索行为、抗焦虑行为、社会和性行为
Cheryl A Frye,Jason J Paris,Madeline E Rhodes
Cheryl A Frye
The progesterone (P(4)) metabolite and neurosteroid, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) acts in the midbrain ventral tegmental area (VTA) to modulate lordosis of female rats. 3alpha,5alpha-THP also mediates exploratory, aff...
Integrating the open field, elevated plus maze and light/dark box to assess different types of emotional behaviors in one single trial [0.03%]
一种新的方法在一个实验环节中同时使用明暗箱、高架十字迷宫和旷场评价小鼠不同的情绪行为学表型
André Ramos,Elayne Pereira,Gisele C Martins et al.
André Ramos et al.
Current anxiety tests do not provide, individually, a pure and complete picture of an animal's emotional profile. Therefore, many authors test their experimental hypotheses using a series of anxiety-related tests, which are thought to refle...
Influence of prenatal stress on behavioral, endocrine, and cytokine responses to adulthood bacterial endotoxin exposure [0.03%]
孕期应激对成人期细菌内毒素暴露所致行为、内分泌及细胞因子反应的影响
Rachel A Kohman,Andrew J Tarr,Cameron E Day et al.
Rachel A Kohman et al.
Prior research suggests that prenatal stress, among other effects, can lead to hyper-reactivity of the offspring's hypothalamic-pituitary-adrenal (HPA) axis and alterations in immune function. These stress-induced changes have been linked t...
Cellular prion protein modulates defensive attention and innate fear-induced behaviour evoked in transgenic mice submitted to an agonistic encounter with the tropical coral snake Oxyrhopus guibei [0.03%]
小细胞毒扁尾海蛇诱发转基因小鼠攻击性遭遇中的防御注意力和先天恐惧行为受到细胞内原核蛋白的调节
Bruno Lobão-Soares,Roger Walz,Rui Daniel Schröder Prediger et al.
Bruno Lobão-Soares et al.
The cellular prion protein (PrP(C)) is a neuronal anchored glycoprotein that has been associated with distinct functions in the CNS, such as cellular adhesion and differentiation, synaptic plasticity and cognition. Here we investigated the ...
Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats [0.03%]
慢性轻度压力产生明确的抑郁行为但产生模棱两可的焦虑样行为
Hajnalka Kompagne,György Bárdos,Gábor Szénási et al.
Hajnalka Kompagne et al.
A 3-week chronic mild stress (CMS) protocol decreased sucrose preference of rats and increased immobility in the forced swim test. It also induced social avoidance and increased grooming, but acted as if reducing anxiety in the plus-maze. S...
Spatial choices of macaque monkeys based on the visual representation of the response space: rotation of the stimuli [0.03%]
基于视觉反应空间表征的猕猴的空间选择：刺激旋转的影响
Jan Nedvidek,Tereza Nekovarova,Jan Bures
Jan Nedvidek
In earlier experiments we have demonstrated that macaque monkeys (Macaca mulatta) are able to use abstract visual stimuli presented on a computer screen to make spatial choices in the real environment. In those experiments a touch board ("r...
Association between a longer duration of illness, age and lower frontal lobe grey matter volume in schizophrenia [0.03%]
精神分裂症病程较长、年龄与额叶灰质体积降低有关联
Preethi Premkumar,Dominic Fannon,Elizabeth Kuipers et al.
Preethi Premkumar et al.
The frontal lobe has an extended maturation period and may be vulnerable to the long-term effects of schizophrenia. We tested this hypothesis by studying the relationship between duration of illness (DoI), grey matter (GM) and cerebro-spina...
Olfactory cues are sufficient to elicit social approach behaviors but not social transmission of food preference in C57BL/6J mice [0.03%]
嗅觉线索足以激发出色性接近行为但不能激发C57BL/6J小鼠食物偏好的社会传递
Bryce C Ryan,Nancy B Young,Sheryl S Moy et al.
Bryce C Ryan et al.
Mouse models for the study of autistic-like behaviors are increasingly needed to test hypotheses about the causes of autism, and to evaluate potential treatments. Both the automated three-chambered social approach test and social transmissi...
The microinjection of AMPA receptor antagonist into the accumbens shell failed to change food intake, but reduced fear-motivated behaviour in free-feeding female rats [0.03%]
AMPA受体拮抗剂微注射到伏隔核壳核未能改变自由进食大鼠的摄食行为，但减少了恐惧驱动的行为
Isabel Cristina da Cunha,Aparecida Marcelino de Nazareth,Juliano Cordova Vargas et al.
Isabel Cristina da Cunha et al.
This study investigated the effect of the AMPA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 2.5 and 5.0 nmol/side) microinjected into the core and shell sub-regions of the accumbens (Acb) nucleus, on food intake and the l...
Oligomers of the amyloid-beta protein disrupt working memory: confirmation with two behavioral procedures [0.03%]
寡聚体淀粉样蛋白-β破坏工作记忆：两种行为程序的验证结果
Alan Poling,Kineta Morgan-Paisley,John J Panos et al.
Alan Poling et al.
Converging lines of evidence suggest that oligomers of amyloid-beta play a role in the cognitive impairment characteristic of Alzheimer's disease, but only three studies have provided experimental evidence of such impairment. To provide add...