Association study of the cytochrome P450 17 gene polymorphism with personality traits in healthy subjects [0.03%]
Yoshihiko Matsumoto,Akihito Suzuki,Naoshi Shibuya et al.
Yoshihiko Matsumoto et al.
There have been several studies suggesting that sex hormones are involved in characterization of human mental function and behaviour. Recently, it has been reported that the -34T/C polymorphism of cytochrome P450 17 (CYP17) gene affects sex...
Cocaine withdrawal enhances pentobarbital-induced sleep in rats: evidence of GABAergic modulation [0.03%]
苯巴比妥诱导的小鼠睡眠受可卡因戒断的影响：γ-氨基丁酸能调节的证据
Yuan Ma,Hong Ma,Jin-Tae Hong et al.
Yuan Ma et al.
We intended to clarify whether pentobarbital-induced sleep in rats is affected during cocaine withdrawal and whether GABAergic systems are involved in this sleep. Cocaine (20mg/kg) was administered subcutaneously (s.c.) to rats once per day...
Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat [0.03%]
姜黄素对血栓栓塞性卒中模型神经保护作用的有效剂量范围及治疗窗研究
Preeti Dohare,Puja Garg,Vikas Jain et al.
Preeti Dohare et al.
Curcumin (diferuloylmethane), an active ingredient of turmeric, obtained from the powdered rhizomes of Curcuma longa Linn., has been traditionally recognized for treatment of several diseases. To evaluate the potential clinical use of curcu...
Early deficits in motor coordination and cognitive dysfunction in a mouse model of the neurodegenerative lysosomal storage disorder, Sandhoff disease [0.03%]
Sandhoff病神经退行性溶酶体贮积症小鼠模型中运动共济失调和认知功能的早期缺陷
Maria Gulinello,Fengying Chen,Kostantin Dobrenis
Maria Gulinello
Mouse models of lysosomal storage diseases, including Sandhoff disease, are frequently employed to test therapies directed at the central nervous system. We backbred such mice and conducted a behavioral test battery which included sensorimo...
Overshadowing in conditioned taste aversion or in conditioned emotional response after neonatal ventral hippocampal lesions in rats [0.03%]
大鼠出生后海马腹侧损伤后的条件化情感反应或条件化厌恶反应中的掩盖作用
Carlos Eduardo Macedo,Marie-Josée Angst,Daniel Gounot et al.
Carlos Eduardo Macedo et al.
The neonatal hippocampus lesion thought to model schizophrenia should show the same modifications in behavioural tests as other models, especially pharmacological models, namely decreased latent inhibition, blocking and overshadowing. The p...
The hemodynamics of cognitive control: the level of concentration of oxygenated hemoglobin in the superior prefrontal cortex varies as a function of performance in a modified Stroop task [0.03%]
认知控制的血流动力学：顶前额叶皮层氧合血红蛋白浓度的变化是stroop任务表现的函数
José León-Carrion,Jesús Damas-López,Juan Francisco Martín-Rodríguez et al.
José León-Carrion et al.
The purpose of this study was to establish the relationship between the hemodynamic response of prefrontal cortex (PFC) and individual differences in cognitive control, as measured by a color-word interference task. Twenty-five healthy volu...
The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats [0.03%]
cannabinoid CB1受体拮抗剂AM 4113和反激动剂AM 251对大鼠摄食行为的类似影响
Janel Hodge,Joshua P Bow,Kimberly S Plyler et al.
Janel Hodge et al.
Cannabinoid CB1 inverse agonists such as rimonabant and AM 251 hold therapeutic promise as appetite suppressants, but the extent to which non-motivational factors contribute to their anorectic effects is not fully known. Examination of the ...
Sex differences in a virtual water maze: an eye tracking and pupillometry study [0.03%]
基于眼动和瞳孔测量的虚拟水中迷宫实验中的性别差异研究
Sven C Mueller,Carl P T Jackson,Ron W Skelton
Sven C Mueller
Sex differences in human spatial navigation are well known. However, the exact strategies that males and females employ in order to navigate successfully around the environment are unclear. While some researchers propose that males prefer e...
Basal behavioral characterization of hsf1 deficient mice and its cellular and behavioral abnormalities underlying chronic unpredictable stressors [0.03%]
HSF1基因敲除小鼠的基础行为特征及其慢性不可预测应激下的细胞和行为异常表型分析
Xiongzhao Zhu,Ming Cheng,Min Peng et al.
Xiongzhao Zhu et al.
The heat shock factor 1 (HSF1) is a major transcriptional factor that controls the rapid induction of heat shock proteins in response to various environmental stressors. In this study, we globally investigated the effect of HSF1 deficiency ...
Riju Ray,James Loughead,Ze Wang et al.
Riju Ray et al.
Advances in neuroimaging and genomics provide an unprecedented opportunity to accelerate medication development for nicotine dependence and other addictions. Neuroimaging studies have begun to elucidate the functional neuroanatomy and neuro...