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Behavioural brain research. 2008 Nov 21;193(2):315-9. doi: 10.1016/j.bbr.2008.06.016 Q22.32025

Early deficits in motor coordination and cognitive dysfunction in a mouse model of the neurodegenerative lysosomal storage disorder, Sandhoff disease

Sandhoff病神经退行性溶酶体贮积症小鼠模型中运动共济失调和认知功能的早期缺陷 翻译改进

Maria Gulinello  1, Fengying Chen, Kostantin Dobrenis

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  • 1 Behavioral Core Facility, Dominick S. Purpura Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA.
  • DOI: 10.1016/j.bbr.2008.06.016 PMID: 18611415

    摘要 Ai翻译

    Mouse models of lysosomal storage diseases, including Sandhoff disease, are frequently employed to test therapies directed at the central nervous system. We backbred such mice and conducted a behavioral test battery which included sensorimotor and cognitive assessments. This is the first report of short-term memory deficits in a murine model of Sandhoff disease. We also document early onset of motor deficits using the balance beam test. ... ...点击完成人机验证后继续浏览
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    期刊名:Behavioural brain research

    缩写:BEHAV BRAIN RES

    ISSN:0166-4328

    e-ISSN:1872-7549

    IF/分区:2.3/Q2

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    Early deficits in motor coordination and cognitive dysfunction in a mouse model of the neurodegenerative lysosomal storage disorder, Sandhoff disease