Soudanones H and I from a freshwater fungus Hongkongmyces sp [0.03%]
来自淡水真菌Hongkongmyces sp.的soudanones H和I
T&#x;ea P Cameron,Tamam El-Elimat,Sonja L Knowles et al.
T&#x;ea P Cameron et al.
Two new compounds were isolated from a freshwater fungus [Hongkongmyces sp. (strain G892)] by bioactivity-directed fractionation against Plasmodium falciparum. The structures of 1 and 2 were elucidated with the use of HRMS and NMR data, and...
Lewis Acid-Catalyzed Chemoselective Reduction of β,γ-Unsaturated-α-Keto Esters with Hantzsch's Ester [0.03%]
路易斯酸催化下的汉兹克酯与β,γ-不饱和-α-酮酸酯的选择性还原反应
Arun K Ghosh,Tristan John McDonald
Arun K Ghosh
We investigated chemoselective reduction of β,γ-unsaturated α-keto esters with Hantzsch ester in the presence of various Lewis acids. Among conditions surveyed for reduction with Hantzsch ester, stoichiometric TiCl4 (1.05 equiv) provided...
Bioinspired synthesis of a lactam analogue of abyssomicin C [0.03%]
受启发的天冬氨酸酮酸内酯合成及环化反应构建 abyssomicin C 合成途径中的关键骨架化合物
A Cole Edwards,Joshua G Pierce
A Cole Edwards
The bioinspired approach to abyssomicin C developed by Sorensen has been utilized to prepare a novel analog containing an α, β-unsaturated lactam. This synthesis was designed to utilize the intramolecular Diels-Alder reaction in late-stag...
Advances in Vicinal Dicarbo-C-H-functionalization of Five-Membered Heteroarenes via Palladium/Norbornene Cooperative Catalysis [0.03%]
钯/双环烯烃协同催化五元杂芳烃邻碳官能团化研究进展
Yun Zhou,Renhe Li,Rong Ye et al.
Yun Zhou et al.
Direct introduction of two carbon substituents to less functionalized aromatic cores has been an attractive objective for late-stage modification and streamlined synthesis of complex molecules. Using the palladium/norbornene (Pd/NBE) cooper...
Jesus M Madrigal Lombera,Ian B Seiple
Jesus M Madrigal Lombera
Resorcinolic macrolides are a large class of fungal natural products with conserved resorcinolic ester cores within highly variable ten- to fourteen-membered macrocycles. They exhibit a broad range of biological activities, depending largel...
Mahshid Attarroshan,Bryan Chacon Vazquez,Caden R Andrews et al.
Mahshid Attarroshan et al.
A copper-catalyst system for the chemoselective reduction of electronically diverse chalcones under mild reaction conditions is reported here. This straightforward method employs phenylsilane (PhSiH3) as a mild hydride source, 4,5-diazafluo...
Copper(II) NHC pincer complexes containing 1,2,3-triazole units: Synthesis, structure and catalysis for C─N bond forming reactions [0.03%]
含1,2,3-三唑单元的二价铜NHC钳形配合物：合成、结构及成氮反应催化性能研究
Mohsen Teimouri,Mahshid Attarroshan,Bruno Donnadieu et al.
Mohsen Teimouri et al.
Two new tridentate copper(II) N-heterocyclic carbene (NHC) pincer complexes with triazolyl donor groups, L2, [TrzmPymBI][PF6] and L3, [bTrzmBI][PF6], were synthesized and characterized by X-ray single crystal analysis and elemental analysis...
Gram-scale synthesis of the thiazolidinedione-based mitoNEET ligand NL-1 using a Hantzsch ester reduction [0.03%]
采用汉兹赫尔酯还原法克级合成线粒体受体MitoNEET的配体NL-1
James Mersch,Yehenew Agazie,Michael Menze et al.
James Mersch et al.
MitoNEET (CISD1), an [2Fe-2S] cluster protein located on the outer mitochondrial membrane and known for its role in cellular redox regulation and bioenergetics, has been identified as a novel ferroptosis-related drug target in neurodegenera...
John Kim,Anna Page,Ryan T Vanderlinden et al.
John Kim et al.
Chiral α-amino- and α-amidoboronates are established pharmacophores in numerous drugs and drug candidates, however, methods to prepare this motif are limited. We report the preparation of cyclic α-amino boronates via a three-component co...
Oxidative Construction of Unusual Indole-Derived Intermediates en Route to Conodusine A [0.03%]
康努多辛A生物合成中不寻常的吲哚衍生物中间体的氧化构建路径研究
Alexander J Hughes,Steven D Townsend
Alexander J Hughes
We describe several approaches to the tricyclic core of conodusine A. Synthesis of a macrocyclic alkene set the stage for 1,2-olefin difunctionalization with conodusine's pendent amine. Unanticipated reactivity of an unusually labile indole...