Exploring the Mechanism of Feiyanning formula and its extract Apigenin Against EGFR-TKIs Resistance in Non-Small Cell Lung cancer Based on UPLC-HRMS and Experimental Validation [0.03%]
基于UPLC-HRMS和实验验证飞泥宁方及其有效成分Apigenin抑制EGFR-TKI耐药非小细胞肺癌的作用机制研究
Yang Han,Lijing Jiao,Hailun Zhou et al.
Yang Han et al.
Ethnopharmacological relevance: Drug resistance in lung cancer poses a significant challenge in clinical treatment. Feiyanning formula (FYN) is a traditional Chinese medicine formula developed through years of clinical pr...
EBBA-detector: An effective detector for defect detection in solar panel EL images with unbalanced data [0.03%]
基于不平衡数据的光伏组件EL图像缺陷检测方法EBBA-Detector
Yixing Zhang,Ziyan Mo,Zhuan Xin et al.
Yixing Zhang et al.
Through experimental validation on a large-scale electroluminescence (EL) dataset, the proposed method has achieved significant improvements in detection performance, with a mean Average Precision (mAP) of 89.85%, outperforming other models in multiple defect category detections.
Experiment and Analysis of Termination Robustness Design for 1200 V 4H-SiC MOSFET [0.03%]
基于1200V 4H-SIC MOSFET的终端耐雪崩设计研究与分析
Mengyuan Yu,Yi Shen,Hongping Ma et al.
Mengyuan Yu et al.
TCAD simulations and experimental validation demonstrate that the improved design stabilizes BV within 2% deviation during 1000 h HTRB testing, which significantly enhances termination robustness.
Deciphering mitochondrial dysfunction in keratoconus: Insights into ACSL4 from machine learning-based bulk and single-cell transcriptome analyses and experimental validation [0.03%]
角膜扩张症中线粒体功能障碍的解析：基于机器学习的批量和单细胞转录组分析以及ACS L4的实验验证见解
Yuchen Cai,Tianyi Zhou,Xueyao Cai et al.
Yuchen Cai et al.
Keratoconus (KC) is a prevalent ectatic corneal disease and the leading cause of corneal transplantation globally. Despite evidence of mitochondrial abnormalities in KC, the underlying mechanisms remain unclear. Our aim was to investigate t...
Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation [0.03%]
探究线粒体代谢和免疫浸润在心肌梗死中的作用：生物信息学和实验验证的新见解
Jingyi Hou,Lihan Wang,Naiqiang Zhu et al.
Jingyi Hou et al.
Background: Mitochondrial metabolism and immune inflammation play pivotal roles in the MI pathogenesis of myocardial infarction (MI); however, their interplay remains unclear. This study aimed to clarify the roles of mito...
Unveiling the immunopharmacological mechanisms of Danggui Yinzi (DGYZ) in treating chronic urticaria: insights from network pharmacology and experimental validation [0.03%]
当归饮子治疗慢性荨麻疹的免疫药理机制研究：网络药理学与实验验证相结合的探索性研究
Xu-Rui Wang,An-Jing Chen,Chang-Cheng Hou et al.
Xu-Rui Wang et al.
Background: Chronic urticaria (CU), a prevalent and often debilitating allergic skin disorder, is primarily triggered by mast cell degranulation. Danggui Yinzi (DGYZ), a traditional Chinese medicine formula, has been empl...
Integrating network pharmacology, experimental validation and molecular dynamics simulation to investigate the underlying mechanism of apigenin against diabetic wound [0.03%]
整合网络药理学、实验验证和分子动力学模拟研究芹菜素抗糖尿病伤口的潜在机制
Pengpeng Pu,Fangjian Zheng,Huihui Wang et al.
Pengpeng Pu et al.
Finally, the experimental validation further confirmed the regulatory effect of API on PI3K-AKT signaling and cell apoptotic pathway.
In silico analysis of quorum sensing modulators: Insights into molecular docking and dynamics and potential therapeutic applications [0.03%]
群体感应调节剂的计算机分析：分子对接和动力学及潜在治疗应用的见解
Ali Alisaac
Ali Alisaac
Further experimental validation is needed to confirm its therapeutic implications. Copyright: © 2025 Ali Alisaac.
Enzymatic Conversion of Mixed Neem (Azadirachta indica) and Nile Tilapia (Oreochromis niloticus) Oils into Biolubricants: A Green Biocatalytic Approach [0.03%]
利用混合尼姆（Azadirachta indica）和尼罗罗非鱼（Oreochromis niloticus）油脂绿色生物催化制备生物润滑油
Francisco Simão Neto,Patrick da Silva Sousa,Rafael Leandro Fernandes Melo et al.
Francisco Simão Neto et al.
The optimal conditionsthe molar ratio of 1:5 (mol/mol), 10% biocatalyst load, and a reaction time of 48 hachieved a predicted ester conversion of 97%, with experimental validation confirming 92.80 ± 0.03%.
Molecular engineering of gold nanocluster properties via peptide ligand charge state and topological modulation [0.03%]
通过肽配体电荷态和拓扑调制调控金纳米团簇性质的分子工程学研究
Pakawat Toomjeen,Unnop Srikulwong,Adulvit Chuaephon et al.
Pakawat Toomjeen et al.
This study advances our understanding of the interactions between peptides and AuNCs and provides the basis for future experimental validation and application-driven modifications.
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