Spatial heterogeneity, stromal phenotypes, and therapeutic vulnerabilities in colorectal cancer peritoneal metastasis [0.03%]
腹膜转移性结直肠癌的时空异质性、间质表型和治疗脆弱性
Johnny Chin-Ann Ong,Joseph J Zhao,Ying Liu et al.
Johnny Chin-Ann Ong et al.
Purpose: Peritoneal metastases (PM) in colorectal cancer (CRC) portend a poor prognosis. We sought to elucidate molecular features differentiating primary tumors (PTs) from PMs and actionable targets facilitating transcoe...
CCN1 Promotes Mesenchymal Phenotype Transition Through Activating NF-κB Signaling Pathway Regulated by S100A8 in Glioma Stem Cells [0.03%]
S100A8通过激活NF-κB信号通路促进胶质瘤干细胞间充质表型转化及其靶向逆转研究
Xing Guo,Shuhua Guo,Feng Tian et al.
Xing Guo et al.
Background: The presence of glioma stem cells (GSCs) and the occurrence of mesenchymal phenotype transition contribute to the miserable prognosis of glioblastoma (GBM). Cellular communication network factor 1 (CCN1) is up...
STAMBPL1/TRIM21 Balances AXL Stability Impacting Mesenchymal Phenotype and Immune Response in KIRC [0.03%]
STAMBPL1/TRIM21在透明细胞肾细胞癌中平衡AXL稳定性影响间质表型和免疫反应
Shiyu Huang,Xuke Qin,Shujie Fu et al.
Shiyu Huang et al.
Kidney renal clear cell carcinoma (KIRC) is recognized as an immunogenic tumor, and immunotherapy is incorporated into its treatment landscape for decades. The acquisition of a tumor mesenchymal phenotype through epithelial-to-mesenchymal t...
Overexpression of Basonuclin Zinc Finger Protein 2 in stromal cell is related to mesenchymal phenotype and immunosuppression of mucinous colorectal adenocarcinoma [0.03%]
黏液性结直肠腺癌间质细胞Basonuclin锌指蛋白2高表达与间质表型和免疫抑制相关性研究
Qing-Zhong Yin,Yuan-Jie Liu,Qian Zhang et al.
Qing-Zhong Yin et al.
Background: Mucinous carcinoma (MC) is a distinct histologic subtype of colorectal cancer (CRC) that is less studied and associated with poor prognosis. This study aimed to identify MC-specific therapeutic targets and bio...
The highly metastatic 4T1 breast carcinoma model possesses features of a hybrid epithelial/mesenchymal phenotype [0.03%]
高转移性的4T1乳腺癌模型具有上皮间充质混合表型的特征
Mary E Herndon,Mitchell Ayers,Katherine N Gibson-Corley et al.
Mary E Herndon et al.
Epithelial-mesenchymal transitions (EMTs) are thought to promote metastasis via downregulation of E-cadherin (also known as Cdh1) and upregulation of mesenchymal markers such as N-cadherin (Cdh2) and vimentin (Vim). Contrary to this, E-cadh...
GJA4 expressed on cancer associated fibroblasts (CAFs)-A 'promoter' of the mesenchymal phenotype [0.03%]
癌相关成纤维细胞(CAFs)上GJA4的表达-促间质表型形成因子
Qian-Wen Ye,Yuan-Jie Liu,Jia-Qi Li et al.
Qian-Wen Ye et al.
Background: Colorectal cancer (CRC) is the third most common cancer worldwide. Connexin is a transmembrane protein involved in gap junctions (GJs) formation. Our previous study found that connexin 37 (Cx37), encoded by ga...
UCHL3 induces radiation resistance and acquisition of mesenchymal phenotypes by deubiquitinating POLD4 in glioma stem cells [0.03%]
UCHL3通过去泛素化POLD4诱导胶质瘤干细胞放射抵抗性及间质表型的获得
Ligang Fan,Hongtao You,Xiao Jiang et al.
Ligang Fan et al.
Background: The high degree of intratumoral genomic heterogeneity is a major obstacle for glioblastoma (GBM) tumors, one of the most lethal human malignancies, and is thought to influence conventional therapeutic outcomes...
CSRP1 expression is associated with a mesenchymal, stroma-rich tumor profile and poor prognosis in colon cancer [0.03%]
基底样型结直肠癌的免疫荧光和基因表达特征
Seçil Demirkol Canli
Seçil Demirkol Canli
Background/aim: Cysteine and glycine-rich protein 1 (CSRP1) is involved in the cysteine-rich protein family and is a marker of smooth muscle lineages. In colon cancer, the expression of this gene is associated with poor p...
Elucidating the Role of MicroRNA-18a in Propelling a Hybrid Epithelial-Mesenchymal Phenotype and Driving Malignant Progression in ER-Negative Breast Cancer [0.03%]
阐明MicroRNA-18a在推动ER阴性乳腺癌杂合上皮间质表型和恶性进展中的作用
Madhumathy G Nair,Apoorva D Mavatkar,Chandrakala M Naidu et al.
Madhumathy G Nair et al.
Epigenetic alterations that lead to differential expression of microRNAs (miRNAs/miR) are known to regulate tumour cell states, epithelial-mesenchymal transition (EMT) and the progression to metastasis in breast cancer. This study explores ...
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