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Cells. 2024 May 10;13(10):821. doi: 10.3390/cells13100821 Q25.22025

Elucidating the Role of MicroRNA-18a in Propelling a Hybrid Epithelial-Mesenchymal Phenotype and Driving Malignant Progression in ER-Negative Breast Cancer

阐明MicroRNA-18a在推动ER阴性乳腺癌杂合上皮间质表型和恶性进展中的作用 翻译改进

Madhumathy G Nair  1, Apoorva D Mavatkar  1, Chandrakala M Naidu  1, Snijesh V P  1, Anupama C E  1, Savitha Rajarajan  1, Sarthak Sahoo  2, Gayathri Mohan  3, Vishnu Sunil Jaikumar  4, Rakesh S Ramesh  5, Srinath B S  6, Mohit Kumar Jolly  2, Tessy Thomas Maliekal  3, Jyothi S Prabhu  1

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作者单位

  • 1 Division of Molecular Medicine, St. John's Research Institute, St. John's Medical College, Bangalore 560034, Karnataka, India.
  • 2 Department of Bioengineering, Indian Institute of Science (Bangalore), Bengaluru 560012, Karnataka, India.
  • 3 Cancer Research, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram 695014, Kerala, India.
  • 4 Animal Research Facility, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram 695014, Kerala, India.
  • 5 Department of Surgical Oncology, St. John's Medical College and Hospital, Bangalore 560034, Karnataka, India.
  • 6 Department of Surgical Oncology, Sri Shankara Cancer Hospital and Research Centre, Bangalore 560004, Karnataka, India.
  • DOI: 10.3390/cells13100821 PMID: 38786043

    摘要 Ai翻译

    Epigenetic alterations that lead to differential expression of microRNAs (miRNAs/miR) are known to regulate tumour cell states, epithelial-mesenchymal transition (EMT) and the progression to metastasis in breast cancer. This study explores the key contribution of miRNA-18a in mediating a hybrid E/M cell state that is pivotal to the malignant transformation and tumour progression in the aggressive ER-negative subtype of breast cancer. The expression status ... ...点击完成人机验证后继续浏览
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    期刊名:Cells

    缩写:CELLS-BASEL

    ISSN:N/A

    e-ISSN:2073-4409

    IF/分区:5.2/Q2

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    Elucidating the Role of MicroRNA-18a in Propelling a Hybrid Epithelial-Mesenchymal Phenotype and Driving Malignant Progression in ER-Negative Breast Cancer