Brain, behavior, & immunity - health. 2025 Apr 17:46:100992. doi: 10.1016/j.bbih.2025.100992 Q13.52025

Acute stress-induced alterations in short-chain fatty acids: Implications for the intestinal and blood brain barriers

急性应激引起的短链脂肪酸变化：肠屏障和血脑屏障的影响翻译改进

Cristina Rosell-Cardona^{1 2 3}, Sarah-Jane Leigh¹, Emily Knox^{1 2}, Emanuela Tirelli¹, Joshua M Lyte¹, Michael S Goodson⁴, Nancy Kelley-Loughnane⁴, Maria R Aburto^{1 2}, John F Cryan^{1 2}, Gerard Clarke^{1 3}

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作者单位

¹ APC Microbiome Ireland, University College Cork, Cork, Ireland.

² Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.

³ Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland.

⁴ 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, OH, USA.

DOI: 10.1016/j.bbih.2025.100992 PMID: 40510181

摘要中英对照阅读

Unravelling the features of the whole-body response to acute stress exposures is critical to understand this neglected building block of chronic stress. A single acute stress exposure rapidly modulates gut-brain axis signalling including intestinal permeability, but the mechanisms are unclear. Microbially-produced metabolites such as short-chain fatty acids (SCFA) are key effectors within the gut-brain axis which can affect gut and brain function. The aim ... ...点击完成人机验证后继续浏览

解析急性应激暴露引起的全身反应特征，对于理解慢性应激的这一被忽视的基础部分至关重要。单次急性应激暴露可以迅速调节肠道-大脑轴信号传导，包括肠通透性，但其机制尚不清楚。微生物产生的代谢物如短链脂肪酸（SCFA）是肠道-大脑轴中的关键效应器，它们可以影响肠道和脑功能。这项工作的目的是确定急性应激是否调控肠道中SCFA的产生，并了解这对胃肠道和大脑屏障功能的影响。应激降低了结肠中的SCFA浓度，主要是丁酸盐和乙酸盐。这些SCFAs可以在体外模型中以剂量依赖的方式防止LPS引起的肠道和大脑屏障功能破坏。这种功能性保护与紧密连接的数量和形态改变有关。这些结果更好地阐明了急性应激后SCFA对屏障的作用。

关键词：急性应激；屏障；微生物代谢物；微生物-肠道-大脑轴；短链脂肪酸。

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期刊名：Brain behavior immunity health

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ISSN：2666-3546

e-ISSN：2666-3546

IF/分区：3.5/Q1

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Acute stress-induced alterations in short-chain fatty acids: Implications for the intestinal and blood brain barriers

急性应激引起的短链脂肪酸变化：肠屏障和血脑屏障的影响翻译改进

Short-chain fatty acids mediate gut microbiota-brain communication and protect the blood-brain barrier integrity

短链脂肪酸介导肠道微生物群与大脑的沟通并保护血脑屏障的完整性

Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets

胃内输注短链脂肪酸可改善断奶仔猪肠道屏障功能

Midgut microbiota affects the intestinal barrier by producing short-chain fatty acids in Apostichopus japonicus

日本海盘车肠道微生物群通过产生短链脂肪酸影响肠道屏障功能

The interaction among gut microbes, the intestinal barrier and short chain fatty acids

肠道微生物、肠屏障和短链脂肪酸之间的相互作用

Short-chain fatty acids are key mediators of the favorable effects of the Mediterranean diet on intestinal barrier integrity: data from the randomized controlled LIBRE trial

短链脂肪酸是地中海饮食通过LIBRE试验研究中的随机对照试验对肠道屏障完整性有利作用的关键调解因子：来自LIBRE试验的数据

Cefazolin Improves Anesthesia and Surgery-Induced Cognitive Impairments by Modulating Blood-Brain Barrier Function, Gut Bacteria and Short Chain Fatty Acids

通过调节血脑屏障功能、肠道细菌和短链脂肪酸，头孢唑啉改善麻醉和手术导致的认知损伤

Berberine-Based Carbon Quantum Dots Improve Intestinal Barrier Injury and Alleviate Oxidative Stress in C57BL/6 Mice with 5-Fluorouracil-Induced Intestinal Mucositis by Enhancing Gut-Derived Short-Chain Fatty Acids Contents

基于小檗碱的碳量子点通过增强肠道短链脂肪酸改善C57BL/6小鼠5-氟尿嘧啶诱导的肠黏膜炎的肠道屏障损伤和氧化应激损伤

Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood-Brain Barrier Damage

短链脂肪酸通过恢复海马神经发生和血脑屏障功能障碍缓解果糖喂养小鼠的抑郁样行为

Acute stress-induced alterations in short-chain fatty acids: Implications for the intestinal and blood brain barriers

急性应激引起的短链脂肪酸变化：肠屏障和血脑屏障的影响 翻译改进

Short-chain fatty acids mediate gut microbiota-brain communication and protect the blood-brain barrier integrity

短链脂肪酸介导肠道微生物群与大脑的沟通并保护血脑屏障的完整性

Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets

胃内输注短链脂肪酸可改善断奶仔猪肠道屏障功能

Midgut microbiota affects the intestinal barrier by producing short-chain fatty acids in Apostichopus japonicus

日本海盘车肠道微生物群通过产生短链脂肪酸影响肠道屏障功能

The interaction among gut microbes, the intestinal barrier and short chain fatty acids

肠道微生物、肠屏障和短链脂肪酸之间的相互作用

Short-chain fatty acids are key mediators of the favorable effects of the Mediterranean diet on intestinal barrier integrity: data from the randomized controlled LIBRE trial

短链脂肪酸是地中海饮食通过LIBRE试验研究中的随机对照试验对肠道屏障完整性有利作用的关键调解因子：来自LIBRE试验的数据

Cefazolin Improves Anesthesia and Surgery-Induced Cognitive Impairments by Modulating Blood-Brain Barrier Function, Gut Bacteria and Short Chain Fatty Acids

通过调节血脑屏障功能、肠道细菌和短链脂肪酸，头孢唑啉改善麻醉和手术导致的认知损伤

Berberine-Based Carbon Quantum Dots Improve Intestinal Barrier Injury and Alleviate Oxidative Stress in C57BL/6 Mice with 5-Fluorouracil-Induced Intestinal Mucositis by Enhancing Gut-Derived Short-Chain Fatty Acids Contents

基于小檗碱的碳量子点通过增强肠道短链脂肪酸改善C57BL/6小鼠5-氟尿嘧啶诱导的肠黏膜炎的肠道屏障损伤和氧化应激损伤

Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood-Brain Barrier Damage

短链脂肪酸通过恢复海马神经发生和血脑屏障功能障碍缓解果糖喂养小鼠的抑郁样行为

急性应激引起的短链脂肪酸变化：肠屏障和血脑屏障的影响翻译改进