Transdiagnostic determinants of Growth Differentiation Factor-15 (GDF-15) in psychiatric in-patients: age, renal indices, interleukin-6 (IL-6) and soluble urokinase plasminogen activator receptor (suPAR) [0.03%]
精神科住院患者转化诊断型生长分化因子-15(GDF-15)的决定因素：年龄、肾指标、白细胞介素-6(IL-6)和可溶性尿激酶纤溶酶原激活物受体(suPAR)
Evangelia Maria Tsapakis,Eirini Keskilidou,Apostolos Karapatis et al.
Evangelia Maria Tsapakis et al.
Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine implicated in systemic inflammatory and renal stress biology. It remains unclear whether GDF-15 reflects diagnosis-specific biology or transdiagnostic physiological b...
Subclinical neurovascular and immune correlates of post-COVID-19 syndrome detected by retinal imaging [0.03%]
基于眼底图像的后COVID综合征亚临床神经血管和免疫标志物检测结果
Michael Wunderle,Rebecca Wicklein,Andrea Ribeiro et al.
Michael Wunderle et al.
Background: Post-COVID-19 Syndrome (PCS) encompasses a range of persistent symptoms, including cognitive and autonomic disturbances, potentially linked to microvascular or neuroinflammatory mechanisms. Retinal imaging pro...
Multi-omics profiling of oral microbial functional signatures and systemic immune-metabolic features in perinatal depression [0.03%]
围产期抑郁的口腔微生物功能特征及系统性免疫代谢特征多组学研究
Kexin Xue,Chunfei Hu,Zhehao Lin et al.
Kexin Xue et al.
Background: Perinatal depression (PND) occurs during a period marked by profound endocrine, metabolic, and immune adaptation. Although alterations in immune-metabolic regulation have been reported in PND, how such changes...
Peripheral blood DNA methylation partially reports on immune cell type composition in the frontal brain [0.03%]
外周血DNA甲基化在一定程度上反映了前脑免疫细胞类型组成状况
Mandy Meijer,Maggie Po Yuan Fu,Erick Isaac Navarro-Delgado et al.
Mandy Meijer et al.
Most existing DNA methylation (DNAm) studies have used peripheral surrogate tissues to research molecular mechanisms underlying brain disorders and diseases. Initial studies comparing brain to blood primarily at the individual CpG level ana...
Filip Ängeby,Filip Ventorp,Miranda Stiernborg et al.
Filip Ängeby et al.
Background: Previous studies suggest that specific depressive symptoms such as low energy, fatigue, sleep and appetite disturbances are associated with systemic low-grade inflammation. In this study, we investigated assoc...
Interleukin-6 responses to acute stress are not altered in alcohol use disorder despite elevated baseline inflammation [0.03%]
酒精使用障碍患者的急性应激细胞因子白细胞介素-6反应不受影响
Yana Schwarze,Johanna Voges,Sarah Stenger et al.
Yana Schwarze et al.
Acute stress activates the immune system, leading to the release of pro-inflammatory cytokines, such as interleukin-6 (IL-6). Chronic alcohol consumption alters the physiological stress systems and is associated with increased chronic infla...
Preoperative depressive symptoms predict sustained postoperative inflammation and longer hospital stay after cardiac surgery [0.03%]
术前抑郁症状可预测心脏手术后持续性术后炎症和更长的住院时间
Stefan Salzmann,Frank Euteneuer,Ruben Domroese et al.
Stefan Salzmann et al.
Introduction: Psychological distress is common among patients undergoing cardiac surgery and may influence postoperative recovery and inflammation. This retrospective study examined whether preoperative depressive symptom...
Immune dysregulation and neuroinflammation in bipolar disorder: Pathophysiological insights and therapeutic perspectives [0.03%]
双相障碍中的免疫调节异常与神经炎症：病理生理学见解和治疗前景
Floriana De Cillis,Veronica Begni,Ilari D&#x;Aprile et al.
Floriana De Cillis et al.
Bipolar disorder (BD) is increasingly associated with immune system dysregulation encompassing both peripheral and central components. Peripheral low-grade inflammation, marked by elevated proinflammatory cytokines and impaired anti-inflamm...
APOE genotype is associated with Ex vivo inflammatory responses in healthy individuals: Potential implications for Alzheimer's disease [0.03%]
载脂蛋白E基因型与健康人的体外炎症反应相关：阿尔茨海默病的潜在影响
Joan Y Song,Liane E Hunter,Yun Freudenberg-Hua et al.
Joan Y Song et al.
Background: Apolipoprotein E (APOE) genotype and inflammation are each linked to Alzheimer's disease (AD) risk. The APOE-ε4 (APOE4) allele is associated with increased AD risk, while the APOE-ε2 (APOE2) allele is protec...
A targeted metabolic intervention via exercise applied after vaccination shapes kinetics and durability of serum antibody accompanied by a distinct immunometabolic signature: pilot study [0.03%]
运动结合接种疫苗对代谢的靶向干预塑造抗体动力学和持久性及其免疫代谢特征：试点研究
Siddhant Kothadiya,Kaitlyn G Holden,Gabriel P Cutshaw et al.
Siddhant Kothadiya et al.
Vaccination under deliberately varied metabolic conditions provides a framework to identify metabolic determinants of immune response to vaccine and to identify metabolic pathways that may serve as immunomodulators or future adjuvant target...