A protocol for the Teen Bugs study: An integrative, multi-omics approach to understanding the role of the gut microbiome and mesocorticolimbic system in adolescent mental health following early adverse caregiving [0.03%]
儿童Bugs研究协议：整合多组学方法，理解早期不良养育后的肠道微生物组和中导 limbic系统在青少年精神健康中的作用
Genesis D Flores,Zoe F Damon,Mary Ford et al.
Genesis D Flores et al.
Caregiving-related early adversities (crEAs) are potent risk factors for the development of internalizing psychopathology (e.g., depression, anxiety). Alterations to the dopaminergic mesocorticolimbic system, which supports the construction...
From case-control averages to validated subgroups: Interpreting inflammatory and neuroaxonal-injury biomarkers in schizophrenia and major depression [0.03%]
从病例对照平均值到验证亚组：精神分裂症和重大抑郁症中炎症和神经轴突损伤生物标志物的解读
Paul C Guest,Janet L Cunningham,Florian Raabe et al.
Paul C Guest et al.
Psychiatric biomarker research is characterized by subtle but potentially informative biological signals that often lie close to methodological noise. Compared with neurodegenerative or infectious diseases, candidate blood and cerebrospinal...
Maternal health behavior during pregnancy mediates the relationship between maternal stress and newborn telomere length [0.03%]
孕期母亲健康行为介导了母体压力与新生儿端粒长度的关系
Karin de Punder,Malvika Godara,Niklas Speckle et al.
Karin de Punder et al.
Background: Health behaviors play a key role in age-related disease risk and are influenced by psychosocial stress. The period of embryonic and fetal life represents among the most sensitive developmental windows at which...
Social isolation during adolescence alters novel object recognition memory, brain and gut gene expression, and microbiota composition in a sex-specific manner [0.03%]
青春期的社会孤立以性别特异性的方式改变新颖物体识别记忆、脑和肠道基因表达及微生物组构成
Raise Ahmad,Gosia Zobel,Rina Hannaford et al.
Raise Ahmad et al.
Adolescent social isolation is a known risk factor for anxiety and depression related disorders, yet its effects on brain-gut communication and potential sex differences remain unclear. We hypothesised that isolation would heighten anxiety-...
Subjective and objective working memory deficits in the post-acute phase of COVID-19 in a clinical trial population [0.03%]
新冠患者工作记忆的主观和客观缺损：一项临床试验结果
Sofie Buer,Bjørn I Hagen,Arne Søraas et al.
Sofie Buer et al.
Importance: Cognitive difficulties are commonly reported following COVID-19, yet the relationship between subjective and objective working memory (WM) deficits remains unclear. Examining both types of measures may improve...
State educational contexts in childhood and systemic inflammation in later life: Evidence from the health and retirement study [0.03%]
童年时期的国家教育背景与晚年时期机体的系统性炎症反应之间的关系——来自健康与退休调查的证据
Mateo P Farina,Heide Jackson,Jennifer A Ailshire et al.
Mateo P Farina et al.
Chronic, low-grade inflammation is a key biological mechanism linking early-life adversity to morbidity and disability in later adulthood. Although educational attainment has been consistently associated with lower inflammation, the role of...
Investigation of BOLD signal intensities in long COVID patients using 7T functional MRI [0.03%]
利用7T功能性磁共振成像研究长期COVID患者的BOLD信号强度
Maira Inderyas,Kiran Thapaliya,Sonya Marshall-Gradisnik et al.
Maira Inderyas et al.
Long COVID is increasingly associated with disruption in brain homeostasis, manifesting as severe neurological dysfunction, brain fog and cognitive impairment. This present study investigated localised cognitive deficits in long COVID patie...
Lipopolysaccharide-induced systemic inflammation alters courtship ultrasonic vocalizations in male mice [0.03%]
脂多糖诱导的小鼠全身炎症会改变雄性小鼠的求偶超声信号
Mizuki Yamamoto,Haruki Kasahara,Kazuko Hayashi et al.
Mizuki Yamamoto et al.
Background: Sickness behavior comprises a coordinated constellation of motivational, cognitive, and social alterations that emerge during systemic inflammation. Although reductions in locomotion, feeding, and social engag...
Celecoxib adjunct to antidepressants for major depressive disorder: Systematic review and meta-analysis [0.03%]
环氧化酶-2抑制剂作为抗抑郁药增效治疗重度抑郁症的疗效及安全性系统综述和meta分析
Manit Srisurapanont,Chawisa Suradom,Sirijit Suttajit
Manit Srisurapanont
This systematic review and meta-analysis of randomized, placebo-controlled trials evaluated the efficacy, acceptability, and tolerability of celecoxib as an adjunct to antidepressants for major depressive disorder (MDD). PubMed, Embase, the...
Prenatal cigarette exposure induces offspring hyperactivity and affective alterations via gut -brain axis metabolic dysregulation and region-specific neuronal hyperactivation [0.03%]
产前接触香烟通过代谢失调和区域特异性神经元过度活化诱导后代多动和情绪改变
Tian-Lei Zhang,Wen Qiu,Xin-Yu Shi et al.
Tian-Lei Zhang et al.
Prenatal cigarette exposure (PCE) is a major preventable risk factor for neurodevelopmental disorders such as attention-deficit/hyperactivity disorder (ADHD), but the underlying mechanisms extending beyond direct developmental neurotoxicity...