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Frontiers in aging neuroscience. 2021 Oct 13:13:748637. doi: 10.3389/fnagi.2021.748637 Q14.52025

Cefazolin Improves Anesthesia and Surgery-Induced Cognitive Impairments by Modulating Blood-Brain Barrier Function, Gut Bacteria and Short Chain Fatty Acids

通过调节血脑屏障功能、肠道细菌和短链脂肪酸,头孢唑啉改善麻醉和手术导致的认知损伤 翻译改进

Ailin Luo  1, Shan Li  1, Xuan Wang  1, Zheng Xie  1, Shiyong Li  1, Dongyu Hua  1

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  • 1 Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • DOI: 10.3389/fnagi.2021.748637 PMID: 34720997

    摘要 Ai翻译

    Emerging evidence suggests that anesthesia and surgery may induce gut dysbiosis. Gut dysbiosis leads to imbalance in circulating contents of microbiota-derived metabolites and disrupts the integrity of the blood-brain barrier (BBB), contributing to postoperative cognitive dysfunction (POCD). The composition of gut microbiota may be influenced by various antibiotics. However, how perioperative use of antibiotics affects POCD needs more explorations. In the ... ...点击完成人机验证后继续浏览
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    期刊名:Frontiers in aging neuroscience

    缩写:FRONT AGING NEUROSCI

    ISSN:1663-4365

    e-ISSN:1663-4365

    IF/分区:4.5/Q1

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    Cefazolin Improves Anesthesia and Surgery-Induced Cognitive Impairments by Modulating Blood-Brain Barrier Function, Gut Bacteria and Short Chain Fatty Acids