首页 文献索引 SCI期刊 AI助手
首页 正文

JACS Au. 2021 Jun 15;1(8):1147-1157. doi: 10.1021/jacsau.1c00139 Q18.72025

Multiple Roles of SARS-CoV-2 N Protein Facilitated by Proteoform-Specific Interactions with RNA, Host Proteins, and Convalescent Antibodies

SARS-CoV-2核蛋白的多种作用机制及其与RNA、宿主蛋白质和恢复期抗体特异互作的作用形式功能多样性 翻译改进

Corinne A Lutomski  1, Tarick J El-Baba  1, Jani R Bolla  1, Carol V Robinson  1

作者单位 +展开

作者单位

  • 1 Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, OX13QZ Oxford, U.K.

    • DOI: 10.1021/jacsau.1c00139 PMID: 34462738

    摘要 Ai翻译

    The SARS-CoV-2 nucleocapsid (N) protein is a highly immunogenic viral protein that plays essential roles in replication and virion assembly. Here, using native mass spectrometry, we show that dimers are the functional unit of ribonucleoprotein assembly and that N protein binds RNA with a preference for GGG motifs, a common motif in coronavirus packaging signals. Unexpectedly, proteolytic processing of N protein resulted in the formation of additional prote... ...点击完成人机验证后继续浏览
    Copyright © JACS Au. 中文内容为AI机器翻译，仅供参考！

    相关内容

    期刊名：Jacs au

    缩写：

    ISSN：N/A

    e-ISSN：2691-3704

    IF/分区：8.7/Q1

    文章目录 更多期刊信息

    全文链接
    官方链接
    PMC全文
    引文链接
    复制
    已复制！
    推荐内容
    Multiple Roles of SARS-CoV-2 N Protein Facilitated by Proteoform-Specific Interactions with RNA, Host Proteins, and Convalescent Antibodies