首页 文献索引 SCI期刊 AI助手
首页 正文

International journal of biological macromolecules. 2021 Oct 1:188:391-403. doi: 10.1016/j.ijbiomac.2021.08.026 Q18.52025

The method utilized to purify the SARS-CoV-2 N protein can affect its molecular properties

用于纯化SARS-CoV-2 N蛋白的方法会影响其分子特性 翻译改进

Aneta Tarczewska  1, Marta Kolonko-Adamska  2, Mirosław Zarębski  3, Jurek Dobrucki  3, Andrzej Ożyhar  4, Beata Greb-Markiewicz  5

作者单位 +展开

作者单位

  • 1 Department of Biochemistry, Molecular Biology and Biotechnology, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wroclaw, Poland. Electronic address: aneta.tarczewska@pwr.edu.pl.
  • 2 Department of Biochemistry, Molecular Biology and Biotechnology, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wroclaw, Poland. Electronic address: marta.kolonko@pwr.edu.pl.
  • 3 Department of Cell Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Cracow, Poland.
  • 4 Department of Biochemistry, Molecular Biology and Biotechnology, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wroclaw, Poland.
  • 5 Department of Biochemistry, Molecular Biology and Biotechnology, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wroclaw, Poland. Electronic address: beata.greb-markiewicz@pwr.edu.pl.

    • DOI: 10.1016/j.ijbiomac.2021.08.026 PMID: 34371045

    摘要 Ai翻译

    One of the main structural proteins of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the nucleocapsid protein (N). The basic function of this protein is to bind genomic RNA and to form a protective nucleocapsid in the mature virion. The intrinsic ability of the N protein to interact with nucleic acids makes its purification very challenging. Therefore, typically employed purification methods appear to be insufficient for removing nucleic ... ...点击完成人机验证后继续浏览
    Copyright © International journal of biological macromolecules. 中文内容为AI机器翻译，仅供参考！

    相关内容

    期刊名：International journal of biological macromolecules

    缩写：INT J BIOL MACROMOL

    ISSN：0141-8130

    e-ISSN：1879-0003

    IF/分区：8.5/Q1

    文章目录 更多期刊信息

    全文链接
    官方链接
    PMC全文
    引文链接
    复制
    已复制！
    推荐内容
    The method utilized to purify the SARS-CoV-2 N protein can affect its molecular properties