Importance of Polar Effects in Halogen-Atom Transfer from Alkyl Iodides to α‑Aminoalkyl Radicals. A Kinetic and Computational Evaluation of the Role of Structural and Medium Effects [0.03%]
结构和介质效应在碘代烷向α-氨基烷基自由基转移卤原子中的作用的动力学和计算研究
Jacopo Mancini,Chiara Stavagna,Francesco Pileri et al.
Jacopo Mancini et al.
α-Aminoalkyl radicals have emerged as practical halogen-atom transfer (XAT) agents, enabling the formation of carbon radicals from unactivated alkyl and aryl halides under mild conditions. A recent study correctly revised some of the XAT r...
Synthesis of Highly Borylated 2‑Boraindanes through Multiple Borylation of Diynes [0.03%]
二炔的多重硼化反应合成高硼化的2-硼苊化合物
Yuki Nagashima,Mone Suzuki,Takahiro Komaki et al.
Yuki Nagashima et al.
Boraindanes, composed of aromatic two-dimensional (2D) benzene and saturated three-dimensional (3D) boracycle moieties, are considered promising candidates for bioactive compounds/probes, agents for boron neutron capture therapy, and functi...
Synthesis of C sp 3 Chlorinated Compounds from Cyclopropanes, Olefins, and C-H Bonds via Photolysis of Willgerodt-Type Reagents [0.03%]
通过Willgerodt型试剂的光解由环丙烷、烯烃和C-H键合成Csp3氯化化合物
Tin V T Nguyen,Thanh V Q Nguyen,Trinh T H Tran et al.
Tin V T Nguyen et al.
Csp 3-Cl bonds are essential as diversification handles in organic synthesis and are found in many natural products and bioactive molecules. In this work, we introduce a general protocol for the selective chlorination of aryl cyclopropanes,...
Liam Grunwald,Katja-Sophia Csizi,Daniel Klose et al.
Liam Grunwald et al.
Cubane-type iron-sulfur clusters (Fe4S4) are some of the most versatile metallocofactors and, as such, among multiple functions, primarily responsible for mediating challenging electron transfers (ETs). Their efficient ET chemistry is enabl...
An "Inside-Out" Strategy Enables a 14-Step Total Synthesis of Hispidospermidin [0.03%]
“里向外”策略助力他的吡啶碱的十四步全长合成
Charis Amber,Tenta Nakamura,Matthew Amoako et al.
Charis Amber et al.
Traditionally, a retrosynthesis aims to disconnect a molecular target into simpler precursors as quickly as possible, prioritizing the early deconstruction of primary contributors to the molecule's overall structural complexity (i.e., prima...
A Glycopeptide Mosaic Vaccine Elicits Robust Antitumor Immunity by Targeting Glycan Heterogeneity [0.03%]
一种糖肽镶嵌疫苗通过靶向糖链多态性引发强有力的抗肿瘤免疫反应
Ye Wu,Wenjing Ma,Yinyu Jiang et al.
Ye Wu et al.
Aberrantly glycosylated membrane proteins represent promising targets for cancer immunotherapy. However, glycan diversity and heterogeneity pose a challenge to developing effective vaccines against tumors expressing different glycoantigens....
Rosa Gaglione,Martina Schibeci,Erika Piccolo et al.
Rosa Gaglione et al.
The human proteome represents a vast, largely untapped source of encrypted bioactive peptides with therapeutic potential. Here, we report the discovery and functional characterization of three antimicrobial encrypted peptides (EPs) derived ...
PSMA-Targeting Chimeras for Cell-Type-Specific Degradation of Surface Immune Checkpoint Protein PD-L1 [0.03%]
靶向PSMA的嵌合体用于细胞特异性降解PD-L1免疫检查点蛋白
Yuqing Luo,Xiaoxiao Gong,Keren Peng et al.
Yuqing Luo et al.
Lysosome-targeting chimera technology has been utilized to degrade proteins of interest via the endosome-lysosome pathway mediated by endogenous ligands that engage cell-surface transmembrane proteins. Despite their promising potential, cur...
Nanobody-Tethered Transposition for Dual Profiling of Histone Modification and DNA Methylation [0.03%]
基于纳米抗体的转座系统联合检测组蛋白修饰和DNA甲基化状态的新方法
Jizhou Liu,Jindi Zhou,Ziang Lu et al.
Jizhou Liu et al.
DNA methylation and histone modifications are critical epigenetic regulators that orchestrate gene expression and modulate various physiological and pathological processes. However, existing methodologies for simultaneous profiling of these...
Conformational Dynamics and Catalytic Backups in a Hyper-thermostable Engineered Archaeal Protein Tyrosine Phosphatase [0.03%]
一种工程化古菌型蛋白质酪氨酸磷酸酶的构象动力学及催化备份机制研究
Dariia Yehorova,Nikolas Alansson,Ruidan Shen et al.
Dariia Yehorova et al.
Protein tyrosine phosphatases (PTPs) are a family of enzymes that play important roles in regulating cellular signaling pathways. The activity of these enzymes is regulated by the motion of a catalytic loop that places a critical conserved ...