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iScience. 2023 Feb 17;26(2):105995. doi: 10.1016/j.isci.2023.105995 Q14.12025

SARS-CoV-2 N protein mediates intercellular nucleic acid dispersion, a feature reduced in Omicron

SARS-CoV-2 N蛋白介导的细胞间核酸扩散，在奥密克戎变异株中该特征减弱 翻译改进

Jung-Lin Wu  1, I-I Kuan  1, Jing-You Guo  1, Wei-Chia Hsu  1, Wei-Chun Tang  2, Hsin-Ju Chan  3  4, Yu-Ju Chen  3, Bi-Chang Chen  2, Han-Chung Wu  5, James C Liao  1

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作者单位

  • 1 Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.
  • 2 Research Center for Applied Sciences, Academia Sinica, Taipei 115, Taiwan.
  • 3 Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
  • 4 Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan.
  • 5 Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 115, Taiwan.

    • DOI: 10.1016/j.isci.2023.105995 PMID: 36687314

    摘要 Ai翻译

    The coronavirus nucleocapsid (N) protein is known to bind to nucleic acids and facilitate viral genome encapsulation. Here we report that the N protein can mediate RNA or DNA entering neighboring cells through ACE2-independent, receptor (STEAP2)-mediated endocytosis, and achieve gene expression. The effect is more pronounced for the N protein of wild-type SARS-CoV-2 than that of the Omicron variant and other human coronaviruses. This effect is enhanced by ... ...点击完成人机验证后继续浏览
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    期刊名：Iscience

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    e-ISSN：2589-0042

    IF/分区：4.1/Q1

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