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Journal of leukocyte biology. 2013 Aug;94(2):367-76. doi: 10.1189/jlb.0313118 Q23.12025

B7-1/B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3+ regulatory T cells

B7-1/B7-2阻断可消除Foxp3阳性调节T细胞缺如情况下激活的保护性CD8 T细胞作用 翻译改进

James M Ertelt  1, Esra Z Buyukbasaran, Tony T Jiang, Jared H Rowe, Lijun Xin, Sing Sing Way

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  • 1 Division of Infectious Diseases, 3333 Burnet Ave., MLC 7017, Cincinnati, OH 45229, USA. singsing.way@cchmc.org
  • DOI: 10.1189/jlb.0313118 PMID: 23744647

    摘要 Ai翻译

    Although T cell activation has been classically described to require distinct, positive stimulation signals that include B7-1 (CD80) and B7-2 (CD86) costimulation, overriding suppression signals that avert immune-mediated host injury are equally important. How these opposing stimulation and suppression signals work together remains incompletely defined. Our recent studies demonstrate that CD8 Teff activation in response to cognate peptide stimulation is ac... ...点击完成人机验证后继续浏览
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    期刊名:Journal of leukocyte biology

    缩写:J LEUKOCYTE BIOL

    ISSN:0741-5400

    e-ISSN:1938-3673

    IF/分区:3.1/Q2

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    B7-1/B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3+ regulatory T cells