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Journal of immunology (Baltimore, Md. : 1950). 2008 Apr 15;180(8):5267-74. doi: 10.4049/jimmunol.180.8.5267 Q23.42025

CD137 costimulation of CD8+ T cells confers resistance to suppression by virus-induced regulatory T cells

CD137活化可使CD8⁺T细胞免受病毒诱导的调节性T细胞的抑制作用 翻译改进

Shelly J Robertson  1, Ronald J Messer, Aaron B Carmody, Robert S Mittler, Christopher Burlak, Kim J Hasenkrug

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  • 1 Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  • DOI: 10.4049/jimmunol.180.8.5267 PMID: 18390707

    摘要 Ai翻译

    Chronic viral infections cause high levels of morbidity and mortality worldwide, making the development of effective therapies a high priority for improving human health. We have used mice infected with Friend virus as a model to study immunotherapeutic approaches to the cure of chronic retroviral infections. In chronic Friend virus infections CD4(+) T regulatory (Treg) cells suppress CD8(+) T cell effector functions critical for virus clearance. In this s... ...点击完成人机验证后继续浏览
    Copyright © Journal of immunology (Baltimore, Md. : 1950). 中文内容为AI机器翻译,仅供参考!

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    期刊名:Journal of immunology

    缩写:J IMMUNOL

    ISSN:0022-1767

    e-ISSN:1550-6606

    IF/分区:3.4/Q2

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    CD137 costimulation of CD8+ T cells confers resistance to suppression by virus-induced regulatory T cells