Kmt2c and Kmt2d histone methyltransferase deficiencies compromise macrophage function [0.03%]
组蛋白甲基转移酶KMT2C和KMT2D缺失影响巨噬细胞功能
Burcu Al,Yerin Jung,Yubell P Alvarez et al.
Burcu Al et al.
Methylation of histone (H) 3 lysine (K) 4 has a well-established role in innate immune responses, but the contribution of H3K4 methyltransferases Kmt2c and Kmt2d in innate immunity is incompletely understood. Using conditional knockout (KO)...
Nathalia Naranjo-Pinto,Carlos Blanco-Camarillo,Nancy Mora et al.
Nathalia Naranjo-Pinto et al.
Obesity is a disease associated with an increased risk of various medical complications, including cardiovascular problems, diabetes, and infectious diseases. The higher incidence of infections in individuals with obesity is likely due to i...
Neutrophils induce effective antibody responses to the pneumococcal conjugate vaccine by inhibiting regulatory T cells [0.03%]
中性粒细胞通过抑制调节性T细胞诱导肺炎球菌结合疫苗的有效抗体反应
Essi Y I Tchalla,Anagha Betadpur,Andrew Y Khalil et al.
Essi Y I Tchalla et al.
Neutrophils are required for production of protective antibodies in response to the pneumococcal conjugate vaccine (PCV), however, the mechanisms behind that are not known. Here, using a mouse model, we found that depletion of neutrophils a...
Adrita Guha,Praneet Wahi,Girdhari Lal
Adrita Guha
The complement system constitutes a fundamental element of the innate immune response, playing a pivotal role in the identification and eradication of pathogens. The orchestration of complement component activation is closely linked to bone...
New Approach Methodologies (NAMs) Complement but Cannot Replace Animal Models in Critical Care Medicine Research [0.03%]
新近验证的方法学可补充但不能替代危重病医学研究中的动物模型方法学
Marlene E Starr,Matthew D Taylor,Longxiang Su et al.
Marlene E Starr et al.
Critical care research focuses on life-threatening conditions such as sepsis, trauma, hemorrhage, and burn injury, which account for millions of hospitalizations and hundreds of thousands of deaths annually in the United States alone. Recen...
Rachel D Loo,John Blazeck
Rachel D Loo
Emerging evidence has highlighted the influence of cellular metabolism on both cancer and T cell growth and survival, including in the context of adoptive cell immunotherapy. It is known that T cells heavily rely on glycolysis for cell prol...
Dysfunctional neutrophil response in COVID-19 infection varies by subtype [0.03%]
COVID-19感染中按亚型区分的中性粒细胞功能障碍反应不同
Onn Shaun Thein,Kylie B R Belchamber,Jon Hazeldine et al.
Onn Shaun Thein et al.
The SARS-CoV-2 virus significantly evolved with several new strains identified. Transmissibility has increased with each strain, corresponding with a decrease in mortality. We previously demonstrated novel dysfunctional neutrophil responses...
Premature birth and Cesarean section are associated with significant differences in neonatal CD4+ T cell gene expression and function [0.03%]
早产和剖宫产与新生儿CD4+T细胞基因表达和功能存在显著差异
Carlos Jesús Ventura-Martínez,Linda Aimara Kempis-Calanis,Sebastian Mijares-Guevara et al.
Carlos Jesús Ventura-Martínez et al.
Premature birth and cesarean section are associated with increased morbidity and inflammatory diseases. However, their impact on neonatal immunity remains incompletely defined. To explore how gestational age and mode of delivery contribute ...