Three-dimensional modeling of sensory nerve architecture and eosinophil and mast cell interactions in eosinophilic gastrointestinal disease [0.03%]
Ari M Levine,Megan Koch,Julius Herzog et al.
Ari M Levine et al.
Increased sensory nerve density has been described in type II inflammatory conditions and is linked to eosinophil and mast cell infiltration and neuropathic pain. To examine these relationships in eosinophilic gastrointestinal diseases (EGI...
Streptococcus anginosus Activates the NLRP3 Inflammasome to Promote Inflammatory Responses from Macrophages [0.03%]
链球菌激活NLRP3炎性小体促进巨噬细胞的炎症反应
Anika M Arias,Dakota M Reinartz,Chloe Sairs et al.
Anika M Arias et al.
Chronic inflammation and oral dysbiosis are common features of oral squamous cell carcinoma (OSCC). The commensal streptococci, S. anginosus, is increased in oral diseases including OSCC. Our previous work revealed that S. anginosus promote...
Chemokine receptor expression defines a trajectory from monocytes to mature macrophages in the lung [0.03%]
趋化因子受体表达定义了从单核细胞到肺成熟巨噬细胞的发育轨迹
Heather Mathie,Laura Medina-Ruiz,Fabian Schuette et al.
Heather Mathie et al.
CCR1, CCR2 and CCR5 direct recruitment of monocytes and macrophages in inflammation. However, the discrete role for each receptor in monocyte/macrophage biology remains poorly understood, with previous reports citing receptor redundancy. Us...
Immune Landscape of COVID-19 recovery: Nucleocapsid as a major target of CD8+ T cell antiviral responses in convalescent HLA-A*2+ individuals from Brazil [0.03%]
巴西康复者的HLA-A*2等位基因人群新冠病毒特异性CD8+t细胞免疫图谱：核蛋白为主要抗病毒免疫反应靶标
Ágata Lopes-Ribeiro,Geovane Marques-Ferreira,Franklin Pereira Araujo et al.
Ágata Lopes-Ribeiro et al.
Despite advanced knowledge on the SARS-CoV-2-induced immunity, a deeper understanding of how virus-specific responses are assembled upon infection is necessary. Therefore, the present work investigates the MHC-restricted virus-specific resp...
BET inhibition curbs macrophage inflammation, lipid accumulation, and atherogenesis by disrupting the YAP/TAZ-BRD4 axis [0.03%]
BET抑制通过破坏YAP/TAZ-BRD4轴来减轻巨噬细胞炎症、脂质积累和动脉粥样硬化形成
Praveen Krishna Veerasubramanian,Vijaykumar S Meli,Hamza Atcha et al.
Praveen Krishna Veerasubramanian et al.
Macrophage dysfunction is hallmark of atherosclerotic disease, characterized by inflammation and uptake of oxidized low-density lipoproteins (oxLDL). We investigate the role of the epigenetic reader bromodomain-containing protein 4 (BRD4) i...
Mapping the sepsis immune landscape across age and source of infection: lessons from single-cell multi-omics [0.03%]
脓毒症免疫图谱的跨年龄段和感染来源绘制：单细胞多组学的启示
Mihir R Atreya,Basilia Zingarelli
Mihir R Atreya
CD177 Promotes NLR Inflammasome Activation in Acute Respiratory Distress Syndrome by Remodeling Neutrophil Glycolytic Metabolism [0.03%]
CD177通过重塑中性粒细胞糖酵解代谢促进急性呼吸窘迫综合征中NLR炎症小体的激活
Dongfeng Shen,Yuejiao Sun,Yixin Xu et al.
Dongfeng Shen et al.
Acute respiratory distress syndrome (ARDS) is a high-mortality lung disorder driven by excessive neutrophil activation. While neutrophils are central to ARDS, the metabolic pathways fueling their inflammatory response remain unclear. This s...
Macrophage and fibro-adipogenic progenitor (FAP) communication in skeletal muscle regeneration: Tissue homeostasis and pathogenic remodeling [0.03%]
肌营养不良中的巨噬细胞与成脂成纤维前体细胞（FAP）相互作用：从正常骨骼肌再生到病理性肌肉修复和重建的作用机制及功能探讨
Seily Shrestha,Abbey Politeski,Sarah A Dick
Seily Shrestha
Skeletal muscle regeneration depends on coordinated interactions between macrophages, fibro-adipogenic progenitors (FAPs), and muscle stem cells (MuSCs). Following injury, macrophages transition from pro-inflammatory to anti-inflammatory ph...
Yuzhen Ouyang,Mengchuan Luo,Kailin Li et al.
Yuzhen Ouyang et al.
Exhausted T cells (Tex), characterized by impaired cytotoxic function, play a detrimental role in anti-tumor and anti-infection immunity but represent promising therapeutic targets for autoimmune diseases. Persistent exposure to auto-antige...
Macrophage heterogeneity influences cellular response to HIV infection and latency modulation [0.03%]
巨噬细胞异质性影响HIV感染及潜伏期的调节
Michelle E Wong,Laura Rikard-Bell,Salimeh Ebrahimnezhaddarzi et al.
Michelle E Wong et al.
HIV reservoirs persist in macrophages in people with HIV despite antiretroviral therapy, representing a barrier to cure. Factors which govern the establishment and reversal of HIV latency in different macrophage types remain poorly understo...