Christy H Clutter,Daniel T Leung
Christy H Clutter
Mucosal associated invariant T (MAIT) cells are part of a T cell subset that is activated upon presentation of B2 vitamin (riboflavin) metabolites by the major histocompatibility complex, class I related (MR1) protein. Though there is a cle...
Holly Linley,Shafqat Jaigirdar,Lucy Buckingham et al.
Holly Linley et al.
γδ T cells are enriched at barrier sites such as skin, gut and lung, where they protect against cancer and infections, and promote healing. They detect diverse ligands in T cell receptor-dependent or independent manners, producing large q...
Countering tumor-derived PGE2-EP2/4 signaling mediates neutrophil activation [0.03%]
对抗肿瘤源性PGE2-EＰ２／４信号转导可介导中性粒细胞活化
Johanna Bödder,Robbin Kramer,Julia Minnee et al.
Johanna Bödder et al.
Neutrophils have recently been demonstrated to play a variable role in cancer progression, likely due to adaptability to environmental signals that influence neutrophil phenotype and function. In the tumor microenvironment, tumor-derived pr...
EpCAM (CD326) is dispensable for in vitro B cell activation and maintenance of antibody-secreting cells [0.03%]
EpCAM(CD326)对于体外B细胞活化和分泌抗体的细胞维持是不需要的
Shannon R Menzel,Edith Roth,Katharina Pracht et al.
Shannon R Menzel et al.
Antibody-secreting cells (ASCs) provide the foundation for protective humoral immunity following infection or vaccination. Recent advances have revealed substantial phenotypic complexity within the ASC compartment, associated with diverse f...
Basal activation of ERK1/2 blunts the antimicrobial activity of neutrophils from old hosts against antibody-opsonized Streptococcus pneumoniae [0.03%]
老年宿主中ERK1/2基线活化削弱了中性粒细胞对抗体包被的肺炎链球菌的抗菌作用
Shaunna R Simmons,Annabel Rivera,Elsa N Bou Ghanem
Shaunna R Simmons
Age-related decline in neutrophil function reduces vaccine protection against Streptococcus pneumoniae. In vaccinated hosts, neutrophil activation via complement and Fcγ receptors mediates bacterial uptake and killing. Mechanisms behind ag...
Sirtuin 1 is an endogenous NETosis inhibitor that becomes dysfunctional in diabetes [0.03%]
沉默信息调节因子1是内源性NETosis抑制因子，糖尿病会导致其功能失调
Liang De Wang,Feng Chen,Rinkoo Dalan et al.
Liang De Wang et al.
Neutrophils release their chromatin with toxic granular proteins as neutrophil extracellular traps (NETs) when activated. Diabetes exacerbates NET formation (NETosis), resulting in tissue damage and diabetic complications such as non-healin...
ICAM-1 and vascular matrices coordinate skin S1-macrophage formation from blood PDGFRα-lineage monocyte [0.03%]
血管细胞黏附分子-1和基质协调血液来源的PDGFRα单核细胞形成皮肤S1型巨噬细胞
Yu-Tung Li,Akito Inoue,Aoi Fukuda et al.
Yu-Tung Li et al.
Extravasation control of leukocytes and their functional fates are crucial to maintain tissue homeostasis. Leukocyte lineage origin regulates these processes that blood monocytes derived from PDGFRα+ embryonic progenitors (PDGFRα-lineage)...
A conserved upstream element in the mouse Csf1r locus contributes to transcription in hematopoietic and trophoblast cells [0.03%]
小鼠Csf1r基因组中一个保守的上游元件可影响造血细胞和滋养层细胞中的转录水平
Emma Maxwell,Isis Taylor,Cameron Flegg et al.
Emma Maxwell et al.
Expression of the Csf1r gene in mice is restricted to cells of the mononuclear phagocyte system and placental trophoblasts. A conserved element (Csf1r upstream regulatory element A, CUREA) in the mouse Csf1r locus contains transcription sta...
Immunity at the edge: Cell-intrinsic roles for intestinal epithelial cells in host immunity [0.03%]
边缘的免疫作用：肠上皮细胞在宿主免疫中的固有细胞功能
Thomas Charron,Ines Hrichi,Ryan D Pardy
Thomas Charron
As the barrier between the contents of the intestines and the rest of the body, intestinal epithelial cells (IEC) occupy a crucial niche for the health of the organism. They are responsible for nutrient absorption and transfer, barrier main...
Eosinophils: Pathological Mechanisms and Novel Targeted Therapeutic Strategies Across Multiple Disease Spectrums [0.03%]
嗜酸性粒细胞：病理机制及多病谱的新型靶向治疗策略
Yuan Chen,Yuhua Liu
Yuan Chen
Eosinophils are a type of white blood cell belonging to the granulocyte family. Their cytoplasm contains eosinophilic granules that hold various biologically active substances. They perform diverse functions, participating in inflammatory r...