Atorvastatin pre-exposure in hypercholesterolemia remedies 27HC mediated dendritic cell dysfunctions in triple-negative breast cancer [0.03%]
阿托伐他汀预处理通过修复27HC诱导的树突状细胞功能障碍来抑制三阴性乳腺癌进展
Pritha Roy Choudhury,Mohona Chakravarti,Saurav Bera et al.
Pritha Roy Choudhury et al.
Early inception of hypercholesterolemia has led to prevalent statin pre-exposure among cancer patients. Furthermore, emerging associations between increased circulating cholesterol, dyslipidemia, and cancer recurrence have spurred the repur...
Hydrogel-based lineage-specific gene therapy prevents recurrence of corticotroph tumors [0.03%]
基于水凝胶的系谱特异性基因疗法可预防皮质醇分泌细胞肿瘤复发
Junpeng Wang,Zezheng Fang,Jiahao Wang et al.
Junpeng Wang et al.
Pituitary corticotroph tumors are the primary cause of Cushing's disease. Even after transsphenoidal surgery, residual tumor cells frequently persist, leading to a recurrence rate of approximately 20%. However, safe and effective adjuvant t...
Ligand-dependent reprogramming of HNF4A expression and function suppresses multistep hepatocarcinogenesis [0.03%]
配体依赖的HNF4A表达和功能重编程可抑制多阶段肝癌发生
Hikari Okada,Kouki Nio,Naoki Ohno et al.
Hikari Okada et al.
Activation of tumor suppressors represents an attractive strategy for cancer treatment. Hepatocyte nuclear factor 4 alpha (HNF4A) functions as a tumor suppressor in the liver by inhibiting hepatocyte proliferation; however, no effective ago...
Induced pluripotent stem cell-derived dendritic cells potentiate the efficacy of interleukin-12-expressing oncolytic HSV-1 [0.03%]
诱导多能干细胞来源的树突状细胞能够增强表达IL-12溶瘤HSV-1疗效
Satoru Taguchi,Hiroshi Fukuhara,Songjie Cai et al.
Satoru Taguchi et al.
Oncolytic herpes simplex virus type 1 (HSV-1), including marketing-approved G47Δ, elicits antitumor immunity via facilitating antigen presentation during immune-mediated clearance of infected tumor cells. Dendritic cell (DC) therapy should...
The miR-16-1-3p suppresses proliferation and invasiveness via the MDM2-p53 axis in TGF-β1 signaling in osteosarcoma [0.03%]
miR-16-1-3p通过TGF-β1信号传导中的MDM2-p53轴抑制骨肉瘤的增殖和侵袭性
Wenyu Xue,Yuzhe Wang,A V Smirnova et al.
Wenyu Xue et al.
The TGF-β signaling pathway has both tumor-suppressive and metastasis-promoting effects in cancer, yet the molecular determinants governing this switch remain unclear. Here, we investigated the miR-16-1-3p/MDM2/p53 axis as a potential regu...
Targeting SMYD2 improves immunotherapy response in experimental hepatocellular carcinoma [0.03%]
靶向SMYD2可改善实验性肝细胞癌的免疫治疗效果
Bárbara Bueloni,Mariel Fusco,Esteban Fiore et al.
Bárbara Bueloni et al.
Therapeutic options for hepatocellular carcinoma (HCC) remain scarce and limited by resistance, underscoring the need for novel approaches. The lysine methyltransferase SMYD2 is overexpressed in several cancers and regulates oncogenic signa...
Endothelial injury is a central driver of systemic IFN-β toxicity and is reversible through Jak inhibition [0.03%]
内皮损伤是全身IFN-β毒性的主要驱动因素，并可通过Janus激酶抑制逆转
Lianwen Zhang,Linh Pham,Michael B Steele et al.
Lianwen Zhang et al.
Oncolytic viruses (OVs) encoding interferon beta (IFN-β) are under clinical evaluation. IFN-β is an attractive transgene due to its antiproliferative and immunomodulatory properties; however, the systemic effects of sustained IFN-β expre...
Impact of germline RAD51D mutations on breast cancer: Susceptibility to DNA-damaging agents [0.03%]
RAD51D胚系突变与乳腺癌对DNA损伤剂的易感性关系研究
Seongyeon Jo,Wan Cheol Shim,Shinyoung Park et al.
Seongyeon Jo et al.
Germline mutations in homologous recombination-related genes significantly increase the lifetime risk of breast, ovarian, and other cancers; thus, the concept of BRCAness has been extensively studied. In this study, we aimed to investigate ...
Engineering potent TILs from an immune-excluded tumor: Insights from chondrosarcoma [0.03%]
来自免疫隔离肿瘤的工程高效TILs：软骨肉瘤的见解
Rusul Al-Marayaty,Seth M Pollack
Rusul Al-Marayaty
John W Figg,Catherine T Flores
John W Figg