Endothelial injury is a central driver of systemic IFN-β toxicity and is reversible through Jak inhibition
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Oncolytic viruses (OVs) encoding interferon beta (IFN-β) are under clinical evaluation. IFN-β is an attractive transgene due to its antiproliferative and immunomodulatory properties; however, the systemic effects of sustained IFN-β expression remain poorly ... ...
