Wastewater concentrations of rotavirus RNA are associated with infection and vaccination metrics in the USA [0.03%]
美国废水中的轮状病毒RNA浓度与感染和疫苗接种指标相关
Elana M G Chan,Alessandro Zulli,Alexandria B Boehm
Elana M G Chan
Surveillance of rotavirus infections remains critical because vaccines are underutilized in the USA. Using wastewater solids measurements of rotavirus RNA collected over one year from 185 wastewater treatment plants (WWTPs) in the USA, we i...
Gut infection and dysbiosis are hallmarks of severe SARS-CoV-2 variants [0.03%]
肠道感染和菌群失调是严重新冠病毒变异株的标志特征
Santhosh K Nagaraj,Christy M Joy,Rishad Shiraz et al.
Santhosh K Nagaraj et al.
SARS-CoV-2, the virus behind the COVID-19 pandemic, is primarily a respiratory pathogen, with host entry mediated by the ACE2 receptor that determines viral tropism. Notably, in humans, ACE2 is highly expressed in the gastrointestinal (GI) ...
Therapeutic potential of Shigella phage SSG23 against Shigella sonnei biofilms and in BALB/c mice [0.03%]
宋内志贺菌噬菌体SSG23治疗潜力及其抑制生物被膜和BALB/c小鼠感染模型中的宋内志贺菌感染的作用研究
Payel Mondal,Sanjib Das,Anaswara Ramesh et al.
Payel Mondal et al.
Multidrug-resistant (MDR) Shigella spp. threaten global health, renewing interest in phage therapy. Here, we report the isolation and characterization of a novel lytic phage, SSG23, effective against four major Shigella serovars. Phage SSG2...
Impact of naturally occurring hemagglutinin substitutions on antigenicity and fitness of influenza A(H5N1) virus [0.03%]
禽流感病毒血凝素自然突变对抗原性和毒力的影响研究
Li Wang,Masato Hatta,Chenchen Feng et al.
Li Wang et al.
In 2024, a human infection with clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) virus was identified in the United States in an individual with no known exposure. Genetic analysis revealed two hemagglutinin (HA) substitutions, P136...
Andra Buchan,Stephanie Wiedman,Kevin Lambirth et al.
Andra Buchan et al.
Megaphages are bacteriophages (i.e., phages) with exceptionally large genomes that have been discovered computationally across the globe. To date, all have evaded cultivation except phage G, which we examined with multiomics and artificial ...
JNK kinase regulates phosphorylation of HCoV-229E nucleocapsid protein [0.03%]
c-Jun氨基末端激酶调节HCoV-229E核蛋白磷酸化
Yannick Brüggemann,Toni Luise Meister,Natalie Heinen et al.
Yannick Brüggemann et al.
Identifying common host factors essential for the replication cycles of human coronaviruses (HCoV) could help uncover potential therapeutic targets. Mitogen-activated protein kinases (MAPKs) regulate critical cellular signaling pathways. Am...
Discovery and characterization of Sager Creek virus, a new orthohantavirus in prairie voles (Microtus ochrogaster) [0.03%]
萨格溪病毒的发现和分类：一种分布于大草原田鼠（Microtus ochrogaster）中的新型正汉坦病毒属病毒
Nathaniel Mull,Mert Erdin,Michael Letko et al.
Nathaniel Mull et al.
We report the discovery and characterization of a new orthohantavirus species in prairie voles (Microtus ochrogaster) named Sager Creek virus (SACRV). We performed molecular and ecological characterization of SACRV, including genome sequenc...
Transcriptomic response of mosquitoes to Japanese encephalitis virus and identification of its potential entry factors [0.03%]
日本脑炎病毒的蚊虫转录组响应及潜在受体因子识别
Mazhar Hussain,Kayvan Etebari,Rhys H Parry et al.
Mazhar Hussain et al.
Japanese encephalitis virus (JEV), an Orthoflavivirus transmitted by mosquitoes, can cause severe disease in humans, yet its interactions with mosquito vectors remain poorly understood. This study presents the first de novo assembled transc...
Zachary Schiffman,Lauren Garnett,Kaylie N Tran et al.
Zachary Schiffman et al.
Ferrets are highly susceptible to infection with several orthoebolaviruses, including Ebola virus (EBOV), yet they are refractory to infection with the orthomarburgviruses, Marburg virus (MARV) and Ravn virus. This study sought to investiga...
Development of GFP-expressing infectious clones for PRRSV using TAR cloning for antiviral drug screening [0.03%]
利用TAR克隆技术构建PRRSV-GFP表达复制子体系用于抗病毒药物筛选研究
Minze Zhang,Bang Qian,Dusan Kunec et al.
Minze Zhang et al.
Porcine reproductive and respiratory syndrome virus (PRRSV), an Arteriviridae family enveloped RNA virus, is a major swine pathogen. Using yeast transformation-associated recombination (TAR) cloning, we efficiently generated infectious PRRS...