Bo Ye,Lu Xiao,Yuyong Xu et al.
Bo Ye et al.
Canonical WNT signaling plays critical, often opposing roles in heart development and disease, but its context-dependent mechanisms remain unclear. We hypothesized that alternative splicing of Tcf7l2, a key nuclear partner of β-catenin, co...
Differential regulation during development, aging, and disease implies heart cell specific functions of the Mediator Complex [0.03%]
发育、衰老和疾病过程中的调控差异暗示了 mediator 复合物具有心肌细胞特异性功能
Dominic W Kolonay,Chad E Grueter,Kedryn K Baskin
Dominic W Kolonay
Transcription directs the heart's development and adaptation to stress signals, and transcriptional dysregulation contributes to developmental disorders, pathological remodeling and heart failure (HF). Stereotypic changes at the mRNA level ...
Atrial electrical alterations with intact cardiac structure and contractile function in a mouse model of an HCM-linked ACTN2 variant [0.03%]
在与肥厚型心肌病相关的ACTN2突变小鼠模型中，心脏结构和收缩功能保持不变下的心房电学改变
Maya Noureddine,Sophie Broadway-Stringer,Christopher O&#x;Shea et al.
Maya Noureddine et al.
Background: Missense variants of Z-disk protein, alpha-actinin-2 (ACTN2), have been linked to hypertrophic cardiomyopathy (HCM). A novel ACTN2 missense variant, M228T, was identified in family members presenting with HCM ...
Low levels of adropin are associated with acute kidney injury after decongestion in patients with acutely decompensated heart failure [0.03%]
低adropin水平与心力衰竭急性失代偿期利尿去容量化后的急性肾损伤相关
Alexander E Berezin,Tetiana A Berezina,Evgen V Novikov et al.
Alexander E Berezin et al.
Background: Patients with acutely decompensated heart failure (ADHF) demonstrated a high risk of acute kidney injury (AKI) and its transition to acute kidney disease after diuretic therapy to reach euvolemic status. The p...
Perinatal death in pig models of hypertrophic cardiomyopathy carrying sarcomere pathogenic variants [0.03%]
携带肌节致病变异的肥厚型心肌病小鼠模型围产期死亡率升高
Tatiana Flisikowska,Björn Petersen,Giulia Mearini et al.
Tatiana Flisikowska et al.
Hypertrophic cardiomyopathy (HCM) is an autosomal-dominant disease caused by genetic variants in sarcomeric proteins, particularly in myosin binding protein C3 (MYBPC3) and myosin heavy chain 7 (MYH7). Less known is that neonatal forms of H...
Structural and functional characterization of the cardiac mitochondria-associated reticular membranes in the ob/ob mouse model [0.03%]
肥胖型小鼠心脏线粒体相关内质网膜的结构和功能表征
Hala Guedouari,Maya Dia,Juliette Geoffray et al.
Hala Guedouari et al.
Type 2 diabetes (T2D) and obesity strongly lead to diabetic cardiomyopathy (DCM). The involvement of mitochondria-associated reticular membranes (MAMs), a signaling hub in the cardiomyocyte, starts to be demonstrated in T2D-related metaboli...
Glyoxal is a superior fixative to formaldehyde in promoting antigenicity and structural integrity in murine cardiac tissues [0.03%]
甘loxal在促进小鼠心脏组织抗原性和结构完整性方面优于甲醛
Allen C T Teng,Dev Mehangrey,Ava Vandenbelt et al.
Allen C T Teng et al.
Background: Immunofluorescence (IF) is an essential technique for evaluating histological and biochemical changes in tissue specimens. A critical step in IF is sample fixation, typically achieved using formaldehyde-based ...
PP2A-B56α is a key determinant of cardiac protein phosphorylation and functional responses to β-adrenergic signalling [0.03%]
PP2A-B56α是心脏蛋白磷酸化修饰及β肾上腺素能信号转导功能反应的关键决定因子
Alican Güran,Yanlong Ji,Pan Fang et al.
Alican Güran et al.
B56α is a protein phosphatase 2 A (PP2A) regulatory subunit which modulates the heart's inotropic response to acute β-adrenergic receptor (β-AR) stimulation, although knowledge of the underlying molecular mechanisms is limited. In this s...
Performance horses as a model for exercise-associated cardiac arrhythmias and sudden cardiac death [0.03%]
以赛马作为运动相关心律失常和猝死的动物模型
Amanda Avison,Peter W Physick-Sheard,W Glen Pyle
Amanda Avison
This paper reviews the myocardial substrate of horses relative to that of humans and discusses the utility of performance horses as a model of exercise-associated cardiac arrhythmias and sudden cardiac death in athletes. The coronary circul...
Independent and synergistic roles of MEK-ERK1/2 and PKC pathways in regulating functional changes in vascular tissue following flow cessation [0.03%]
MEK-ERK1/2和PKC信号通路在调节血流阻断引起的血管功能变化中的独立及协同作用
Spyridoula Kazantzi,Lars Edvinsson,Kristian Agmund Haanes
Spyridoula Kazantzi
Background: The MEK-ERK1/2 and PKC pathways play critical roles in regulating functional changes in tissues, but their interplay remains poorly understood. The vasculature provides an ideal model to study these pathways, ...