MitoQ Protects Against Oxidative Stress-Induced Mitochondrial Dysregulation in Human Cardiomyocytes [0.03%]
MitoQ通过抑制氧化应激诱导的线粒体功能障碍保护人类心肌细胞
Alex M Parker,Jarmon G Lees,Mitchel Tate et al.
Alex M Parker et al.
The overproduction of reactive oxygen species (ROS) and mitochondrial dysregulation are regarded as key mechanisms in the progression of cardiac remodelling in cardiometabolic diseases including heart failure. Conventional treatments are of...
Myocardial damage post short-term self-administration cocaine usage in rat [0.03%]
短期自用可卡因引起的心肌损伤的动物实验研究
Muhammad Zubair Saleem,Tian Liu,Ningjing Song et al.
Muhammad Zubair Saleem et al.
Cocaine abuse remains a significant risk with profound adverse impact on cardiovascular health. While long-term cocaine addiction-induced cardiotoxicity is well-documented, the underlying mechanism and the molecular effects of short-term re...
Cardiology's best friend: Using naturally occurring disease in dogs to understand heart disease in humans [0.03%]
cardiology的最佳伙伴：利用狗的自然发病了解人类的心脏病
W Glen Pyle
W Glen Pyle
Heart diseases are a leading cause of death globally. Laboratory and preclinical animal models of disease have been critical in advancing our understanding of the mechanisms of pathology, creating diagnostic tools, and developing therapeuti...
Semaphorin 3F is elevated in serum of heart failure patients and inhibits cardiac angiogenesis via the VEGF/Akt/eNOS pathway [0.03%]
血清半导体素3F在心力衰竭患者中升高并通过VEGF/Akt/eNOS途径抑制心脏血管生成
Diana Petrova,Miki Weberbauer,Stephanie Reichert et al.
Diana Petrova et al.
Left ventricular (LV) remodeling in heart failure (HF) is associated with vascular rarefaction and impaired angiogenesis. The inhibition of vascular endothelial growth factor (VEGF)-mediated angiogenesis is a key feature in the pathophysiol...
Combined genome and transcriptome analysis identifies molecular signatures of aortic disease in patients with Marfan syndrome [0.03%]
联合基因组和转录组分析确定了马方综合征患者主动脉疾病的分子特征
Katherine B Stanley,Alexa V Mederos,Ethan H Barksdale et al.
Katherine B Stanley et al.
Introduction: Transcriptional dysregulation in patients with Marfan syndrome (MFS) is complex and not well-defined. There are likely patient-specific and general mechanisms in the aortic pathology. In this study, we combi...
Disruption of ventricular activation by subthreshold delayed afterdepolarizations in RyR2-R420Q catecholaminergic polymorphic ventricular tachycardia [0.03%]
儿茶酚胺多形性室速 RyR2-R420Q 突变小鼠模型中亚阈值迟发后除极诱发心室激活异常
Ewan D Fowler,Salimata L Diakite,Ana M Gomez et al.
Ewan D Fowler et al.
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) carries increased risk of ventricular arrhythmias due to altered Ca2+ regulation associated with mutations in the ryanodine receptor (RyR2). Increas...
Bioinformatics tools for drug repurposing: a tutorial using heart failure as a case study [0.03%]
药物再利用的生物信息学工具教程——以心力衰竭为例研究
Ivo Fonseca,Fábio Trindade,Mário Santos et al.
Ivo Fonseca et al.
Purpose: Drug repurposing is a crucial strategy for researchers worldwide to accelerate drug development and mitigate associated risks and costs. Heart failure (HF) is a major global health problem with high prevalence an...
Genetic deletion or pharmacological inhibition of acetyl-CoA carboxylase 2 enhances fatty acid oxidation and improves cardiac function and survival in the murine ATGL knockout model of severe heart failure [0.03%]
遗传学删除或通过药物抑制乙酰辅酶A羧化酶2可以增强脂肪酸氧化作用，提高心脏ATGL敲除小鼠严重心力衰竭模型的心脏功能和存活率
Mai Usui,Yu Tsurekawa,Tatsuya Ikehara et al.
Mai Usui et al.
Impaired myocardial energetics, including fatty acid oxidation (FAO), is a hallmark feature in the pathophysiology of various disorders. Deficiency of adipose triglyceride lipase (ATGL) results in impaired FAO which leads to severe heart fa...
Blueprint of the distinct metabolite profiles of healthy pig heart chambers [0.03%]
健康猪心脏腔室不同代谢物谱系的蓝图
Retu Haikonen,Topi Meuronen,Ville Koistinen et al.
Retu Haikonen et al.
The heart is one of the most studied organs, with physiological processes and disease research. While it is well-established that significant structural and functional differences exist between the chambers, most studies focus on only a sin...
Pericellular oxygen dynamics in human cardiac fibroblasts and iPSC-cardiomyocytes in high-throughput plates: insights from experiments and modeling [0.03%]
人的心脏成纤维细胞和诱导多能干细胞心肌细胞的周边细胞氧动力学：来自实验与模型的见解
Weizhen Li,David McLeod,Sarah Antonevich et al.
Weizhen Li et al.
Adequate oxygen supply is crucial for proper cellular function. The emergence of high-throughput (HT) expansion of human stem-cell-derived cells and HT in vitro cellular assays for drug testing necessitate monitoring and understanding of th...