JMCC Plus update: new opportunities, new collections, and continued growth [0.03%]
JMCC+更新：新机遇、新刊载和持续发展
Davor Pavlovic,Rebekah Gundry
Davor Pavlovic
Laurent Bultot,Natsuko Tsurudome,Emi Kumazaki et al.
Laurent Bultot et al.
Cardiac aging reflects a convergence of intrinsic molecular damage and maladaptive stress responses that progressively erode myocardial resilience. Accumulating genomic instability, telomere dysfunction, chromatin remodeling, and metabolic ...
Fan Guo,Lingmei Li,Shujuan Xu et al.
Fan Guo et al.
Lactylation is a lactate-driven post-translational modification that directly modifies lysine residues on both histone and non-histone proteins, thereby linking energy metabolism to epigenetic regulation. Its levels are dynamically orchestr...
Acute sildenafil administration decreases the susceptibility to induced atrial fibrillation in sheep [0.03%]
急性西地那非给药降低山羊诱发性房颤的易感性
George W P Madders,Nathan C Denham,David C Hutchings et al.
George W P Madders et al.
Sildenafil has been shown to decrease ventricular arrhythmias. We investigated whether sildenafil could similarly decrease atrial fibrillation (AF) burden through direct effects on atrial electrophysiology. In vivo electrophysiological stud...
RMC-6272, a selective third-generation bi-steric mTORC1 inhibitor, improves cardiac function in pressure overload-induced cardiac hypertrophy [0.03%]
选择性第三代双steric mTORC1抑制剂RMC-6272可改善压力超负荷诱导的心室肥厚小鼠的心脏功能
Mariam Rogge,Johannes Fischer,Tobias Jakobi et al.
Mariam Rogge et al.
Pathological remodeling in cardiomyocytes during heart failure is driven by excessive activation of mTORC1. Preclinical studies in mice demonstrated that reducing mTORC1 activity protects against cardiac dysfunction and hypertrophic remodel...
Spatio-temporal targeting of cardiac cells with lipid nanoparticles after myocardial infarction [0.03%]
心肌梗死后利用脂质纳米颗粒对心脏细胞进行时空定位靶向治疗
Rebecca L Harper,Gabriella E Farrugia,Crisdion Krstevski et al.
Rebecca L Harper et al.
Ischemic heart disease remains the leading cause of morbidity and mortality worldwide. While current therapies prolong survival, they do not address underlying tissue damage. Messenger RNA (mRNA)-based therapies offer a promising alternativ...
Jan M Federspiel,Jan-Christian Reil,Vasco Sequeira
Jan M Federspiel
In hypertrophic cardiomyopathy (HCM), hypertrophy often disproportionately affects the interventricular septum, especially in the obstructive form (oHCM). The reasons for this septal predilection remain debated. Here, we review emerging evi...
Doxorubicin exposure leads to cardiac fibroblast dysregulation and worsens fibrotic remodeling in the pathological heart [0.03%]
多柔比星暴露导致心脏纤维母细胞功能失调并加重病理心脏的纤维化重塑
Sukriti Bagchi,Amy Cai,Alina S Bilal et al.
Sukriti Bagchi et al.
Advances in cancer treatments have enabled long-term patient survival at increasing rates, however these therapies often have chronic adverse side effects of which cardiovascular disease is a major cause for concern. Specifically, patients ...
T-tubular remodeling occurs in a cardiomyocyte-autonomous manner following pathological mechanical stiffness exposure [0.03%]
病理性机械刚度暴露后T管重塑以心肌细胞自主方式进行
Michael Ibrahim,Vasiliki Courelli,Lan Cheng et al.
Michael Ibrahim et al.
T-tubules are invaginations of the cardiomyocyte sarcolemma, essential for excitation-contraction coupling and calcium-induced calcium release. Disruption of T-tubule structure contributes to contractile dysfunction in heart failure, yet th...
Characteristics, clinical outcomes and molecular mechanisms associated with severe diastolic dysfunction in aortic stenosis [0.03%]
主动脉瓣狭窄患者严重舒张功能障碍的特点、临床转归及分子机制
Kyriakos Panaou,Constantijn S Venema,Kees H van Bergeijk et al.
Kyriakos Panaou et al.
Objectives: We aimed to better understand patient characteristics and pathophysiological mechanisms associated with severe diastolic dysfunction in aortic stenosis patients undergoing transcatheter aortic valve implantati...