SARS-CoV-2-infected cardiomyocytes exhibit upregulated necroptosis, but no evidence of mitochondrial permeability transition [0.03%]
SARS-CoV-2感染的心肌细胞坏死性凋亡通路上调，但未发现线粒体过渡孔开放现象
C Gross,S Chatterjee,B E Nilsson-Payant et al.
C Gross et al.
Cardiac involvement in patients infected with COVID-19, in terms of myocarditis and troponin release, is associated with higher mortality. However, the underlying mechanisms are poorly understood. Infection of cardiomyocytes derived from hu...
Persistently increased CaMKIIδ autophosphorylation mediates pathologic SR Ca loss in a murine model of Doxorubicin-induced cardiomyopathy [0.03%]
CaMKIIδ的自身磷酸化介导了多柔比星诱导的心肌病小鼠模型中病理性SR钙丢失
Anna-Lena Feder,Daniel Tarnowski,Anna-Maria Pfützenreuter et al.
Anna-Lena Feder et al.
Background: Doxorubicin (DOX)-induced cardiomyopathy (DICM) manifests as left ventricular (LV) systolic dysfunction. DOX triggers oxidative stress and CaMKIIδ activity in cardiac myocytes. CaMKIIδ activation leads to im...
Identification of circular RNA hsa-PHACTR4_0009 as a new class of biomarker for transposition of the great arteries [0.03%]
圆环RNA hsa-PHACTR4_0009作为动脉导管未闭的新生物标志物的鉴定
Neha Rawal,Anmol Gurgela,Snigdha Kumari et al.
Neha Rawal et al.
Dextro-Transposition of great arteries (d-TGA) is a cardiac birth anomaly with reversed anatomic position of the aorta and pulmonary artery, with a poor prognosis. The molecular aetiology of d-TGA remains elusive, possibly due to polygenic ...
Mitochondrial metabolic remodeling and multi-omics profiling identify plasma biomarkers of myocardial infarction [0.03%]
线粒体代谢重构及多组学分析鉴定出心肌梗死的血浆生物标志物
Selvam Paramasivan,Mitchell C Lock,Roberto A Barrero et al.
Selvam Paramasivan et al.
Mitochondrial dysfunction is a hallmark of myocardial infarction (MI), yet the molecular mechanisms linking metabolic reprogramming in the ischemic myocardium to systemic biomarker signatures remain incompletely understood. In this study, w...
Insulin use promotes pro-inflammatory changes in the transcriptome of atherosclerotic plaques in patients with diabetes mellitus [0.03%]
胰岛素使用促进糖尿病患者动脉粥样硬化斑块转录组的促炎变化
Angelle Bradford,Tadashi Yoshida,Sergiy Sukhanov et al.
Angelle Bradford et al.
Background: Diabetes Mellitus is associated with increased risk of myocardial infarctions and strokes due to accelerated atherosclerotic plaque development and rupture. The mechanisms driving plaque rupture in the diabeti...
Impaired PGC-1α-pAMPK signaling in postmenopausal women undergoing cardiac surgery and the role of nicotinamide in its reversal: Insights from a murine model [0.03%]
绝经后女性心脏手术中PGC-1α-pAMPK信号受损及烟酰胺逆转的机制：来自小鼠模型的启示
Mark Robitaille,Usman Ahmed,Juan Valencia et al.
Mark Robitaille et al.
Postmenopausal women undergoing cardiac surgery face disproportionately worse outcomes compared with men, a disparity linked to mitochondrial dysfunction following estrogen loss. We investigated sex-specific metabolic responses to cardiac s...
Metformin alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy [0.03%]
二甲双胍缓解实验性糖尿病心肌病小鼠的舒张功能障碍
Jordan S F Chan,Seyed Amirhossein Tabatabaei Dakhili,Nadeen R Wu et al.
Jordan S F Chan et al.
The first line therapy for managing type 2 diabetes (T2D), metformin, has been shown to be cardioprotective in humans and several preclinical models of cardiovascular disease. However, there has been limited interrogation into metformin's e...
Cardiomyocyte Rac1 signaling in hypertrophy, arrhythmia, and cardiac stress adaptation [0.03%]
心脏肥大、心律失常和心脏应激适应中的心肌细胞Rac1信号转导
James P Teuber,Rachel E Scissors,Matthew J Brody
James P Teuber
Cardiovascular disease remains the leading cause of mortality globally and is often marked by pathologic cardiac remodeling including hypertrophy and fibrosis that promote the progression to heart failure. Ras-related C3 botulinum toxin sub...
FABP3 and FABP4 promote lipid peroxidation injury during static cold storage of donor heart: Insights from multi-omics and therapeutic targeting [0.03%]
脂肪结合蛋白3和4促进供心静态冷保存过程中的脂质过氧化损伤：多组学及靶向治疗的新见解
Yu Feng,Yongbu Peng,Jincheng Hou et al.
Yu Feng et al.
Objectives: To clarify the mechanism of myocardial injury associated with lipid peroxidation and the role of fatty acid binding proteins FABP3/4 during Static cold storage (SCS) of donor hearts. ...
Cancer-driven cytokine immunomodulation ameliorates cardiac function and suppresses fibrosis [0.03%]
癌症驱动的细胞因子免疫调节改善心脏功能并抑制纤维化
Laris Achlaug,Lama Awwad,Irina Langier Goncalves et al.
Laris Achlaug et al.
Heart failure remains a leading cause of morbidity and mortality worldwide, with limited progress in the development of novel therapies. It has been demonstrated that tumor growth improves cardiac function and reduces myocardial fibrosis in...