PITX2C deficiency promotes arrhythmogenic remodelling via oxidative stress in atrial myocytes [0.03%]
PITX2C缺乏通过氧化应激促进心房肌细胞异位生发灶形成及电重构
Andy Kim,Sébastien Gauvrit,Frederick S Vizeacoumar et al.
Andy Kim et al.
Genetic variants upstream of the paired-like homeodomain transcription factor 2 (PITX2) are the strongest risk variants associated with atrial fibrillation. However, the mechanisms downstream of PITX2 are not completely understood. Here, we...
MicroRNAs and SGLT2 inhibitors in cardiovascular disease: Shared pathways and emerging roles [0.03%]
微小核糖核酸和SGLT2抑制剂在心血管疾病中的共同通路及新兴作用
Anna Bjarvin Bhaskaran,Antoine Sakr,Desislava Doycheva
Anna Bjarvin Bhaskaran
MicroRNAs are non-coding RNA sequences capable of transport outside the cell to regulate essential cellular processes. They are able to induce structural changes implicated in prevalent cardiovascular conditions such as heart failure, ather...
The β1 adrenoceptor (AR) blocker metoprolol normalises βAR cascade and caveolar protein expression and restores β1AR responsiveness in failing right ventricular myocytes [0.03%]
β1肾上腺素能受体(AR)阻滞剂美托洛尔可校正心力衰竭右室肌细胞中βAR信号转导通路及微腔膜蛋白的表达，并恢复β1AR反应性
Ruth Norman,Rachel Stones,Amelia S Power et al.
Ruth Norman et al.
Right ventricular (RV) failure is the leading cause of death in pulmonary artery hypertension (PAH) and treatments that preserve RV contractility are urgently required. β-adrenoceptor blockers (BB) are used clinically in left ventricular f...
Coronary artery disease in smokers with low traditional risk burden: An exploratory analysis of potential genetic susceptibility [0.03%]
低传统风险负担的吸烟者冠心病的遗传易感性探索性分析
Francisco Sousa,Maria Isabel Mendonça,João Adriano Sousa et al.
Francisco Sousa et al.
Background/objectives: Coronary arterial disease (CAD) poses a significant public health challenge, with tobacco as the most predominant modifiable risk factor in young individuals. Despite a strong correlation between to...
JMCC Plus update: new opportunities, new collections, and continued growth [0.03%]
JMCC+更新：新机遇、新刊载和持续发展
Davor Pavlovic,Rebekah Gundry
Davor Pavlovic
Laurent Bultot,Natsuko Tsurudome,Emi Kumazaki et al.
Laurent Bultot et al.
Cardiac aging reflects a convergence of intrinsic molecular damage and maladaptive stress responses that progressively erode myocardial resilience. Accumulating genomic instability, telomere dysfunction, chromatin remodeling, and metabolic ...
Fan Guo,Lingmei Li,Shujuan Xu et al.
Fan Guo et al.
Lactylation is a lactate-driven post-translational modification that directly modifies lysine residues on both histone and non-histone proteins, thereby linking energy metabolism to epigenetic regulation. Its levels are dynamically orchestr...
Acute sildenafil administration decreases the susceptibility to induced atrial fibrillation in sheep [0.03%]
急性西地那非给药降低山羊诱发性房颤的易感性
George W P Madders,Nathan C Denham,David C Hutchings et al.
George W P Madders et al.
Sildenafil has been shown to decrease ventricular arrhythmias. We investigated whether sildenafil could similarly decrease atrial fibrillation (AF) burden through direct effects on atrial electrophysiology. In vivo electrophysiological stud...
RMC-6272, a selective third-generation bi-steric mTORC1 inhibitor, improves cardiac function in pressure overload-induced cardiac hypertrophy [0.03%]
选择性第三代双steric mTORC1抑制剂RMC-6272可改善压力超负荷诱导的心室肥厚小鼠的心脏功能
Mariam Rogge,Johannes Fischer,Tobias Jakobi et al.
Mariam Rogge et al.
Pathological remodeling in cardiomyocytes during heart failure is driven by excessive activation of mTORC1. Preclinical studies in mice demonstrated that reducing mTORC1 activity protects against cardiac dysfunction and hypertrophic remodel...
Spatio-temporal targeting of cardiac cells with lipid nanoparticles after myocardial infarction [0.03%]
心肌梗死后利用脂质纳米颗粒对心脏细胞进行时空定位靶向治疗
Rebecca L Harper,Gabriella E Farrugia,Crisdion Krstevski et al.
Rebecca L Harper et al.
Ischemic heart disease remains the leading cause of morbidity and mortality worldwide. While current therapies prolong survival, they do not address underlying tissue damage. Messenger RNA (mRNA)-based therapies offer a promising alternativ...