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Disruption of ventricular activation by subthreshold delayed afterdepolarizations in RyR2-R420Q catecholaminergic polymorphic ventricular tachycardia

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Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) carries increased risk of ventricular arrhythmias due to altered Ca2+ regulation associated with mutations in the ryanodine receptor (RyR2). Increased Ca2+ ... ...