Deletion of CHOP in beta cell protects mice from cardiovascular complications in type 2 diabetes: evidence from a pre-clinical mouse model [0.03%]
在2型糖尿病小鼠模型中CHOP基因缺失使β细胞免受心血管并发症损害：来自临床前小鼠模型的证据
Balaji Srinivas,Kiran Alluri,Nour-Eddine Rhaleb et al.
Balaji Srinivas et al.
Introduction: Cardiovascular complications are the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D), which is recognized as a major independent risk factor for coronary artery disease, strok...
Age, sex, and vessel region affect the vasomotor function and gene expression signature of the aorta in mice [0.03%]
年龄、性别和血管区域影响小鼠主动脉的血管运动功能和基因表达特征
Lars Saemann,Lotta Hartrumpf,Adrian-Iustin Georgevici et al.
Lars Saemann et al.
Introduction: Vascular aging is associated with endothelial dysfunction, changes in vascular elasticity or stiffness, and the prevalence of cardiovascular diseases. Aging differs by sex. The effects of age, sex, and vesse...
Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy [0.03%]
心脏肌细胞中CaV1.3通道簇的纳米级结构和动力学机制
Niko Schwenzer,Roman Tsukanov,Tobias Kohl et al.
Niko Schwenzer et al.
The clustering of L-type calcium channels (LTCC) for functional regulation of intracellular calcium signaling remains poorly understood. Here we applied super-resolution imaging to study CaV1.3 channel clusters in human iPSC-derived atrial ...
Quantification of morphological, functional, and biochemical features of H9c2 rat cardiomyoblast retinoic acid differentiation [0.03%]
H9c2大鼠心肌细胞分化过程中形态学、功能和生化特征的量化研究
Nicole S York,Joel E Rivera,Mohammadreza Rahmani Manesh et al.
Nicole S York et al.
Cell culture models enable advancement in our understanding of heart development and heart disease. The H9c2 rat ventricular cardiomyoblast cell line can be differentiated with retinoic acid and low serum, leading to morphological, molecula...
Cardiac magnetic resonance imaging and cardiac scintigraphy in the diagnosis of cardiac amyloidosis: A meta-analysis of 4866 patients [0.03%]
基于4866例患者的原发性心脏淀粉样变诊断中心血管磁共振与心肌闪烁显像的meta分析
Mahmoud Balata,Abdelrahman M Attia,Mohamed Ibrahim Gbreel et al.
Mahmoud Balata et al.
Introduction: Cardiac amyloidosis (CA) impacts about 20 % of elderly heart failure patients, leading to myocardial dysfunction and life-threatening risks. However, it often remains undetected due to the significant risks ...
Davor Pavlovic,Rebekah Gundry
Davor Pavlovic
Jules C Hancox,Andrew F James
Jules C Hancox
Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner [0.03%]
Wnt/β-catenin信号通过代谢底物依赖的方式调节心脏Cx43蛋白表达
Omar Kayyem,Ruonan Gu,Ying Xia et al.
Omar Kayyem et al.
Background: Both Nav1.5 and Cx43 are critical for the fast electrical impulse conduction in the myocardium and their reductions create the arrhythmogenic substrate. Wnt/β-catenin signaling is activated in arrhythmogenic ...
Systemic administration of analgesic buprenorphine, but not carprofen, affects cardiomyocyte contractility in rodents [0.03%]
全身给药的止痛剂布苯苯诺菲，而不是卡普罗芬，会影响啮齿动物的心肌细胞收缩力
Inez Duursma,Valentijn Jansen,Nicole Zaat et al.
Inez Duursma et al.
Rodents are often used in cardiac research, where they undergo a wide variety of procedures. To ensure animal welfare, the rodents are often analgesized before, during and/or after a procedure. Contractility measurements in isolated murine ...
Single-cell dynamics reveal a stress-induced decision between hypertrophy and apoptosis in neonatal rat cardiomyocytes [0.03%]
单细胞动态分析揭示新生大鼠心肌细胞应激反应中肥大与凋亡的决定过程
Bryan Chun,Lavie Ngo,Jeffrey J Saucerman
Bryan Chun
Cardiomyocyte hypertrophy and apoptosis underlie cardiomyopathies and heart failure. While previous studies have reported both hypertrophy and apoptosis at the population level, how individual cells commit to these distinct analog and digit...