Jan M Federspiel,Jan-Christian Reil,Vasco Sequeira
Jan M Federspiel
In hypertrophic cardiomyopathy (HCM), hypertrophy often disproportionately affects the interventricular septum, especially in the obstructive form (oHCM). The reasons for this septal predilection remain debated. Here, we review emerging evi...
Doxorubicin exposure leads to cardiac fibroblast dysregulation and worsens fibrotic remodeling in the pathological heart [0.03%]
多柔比星暴露导致心脏纤维母细胞功能失调并加重病理心脏的纤维化重塑
Sukriti Bagchi,Amy Cai,Alina S Bilal et al.
Sukriti Bagchi et al.
Advances in cancer treatments have enabled long-term patient survival at increasing rates, however these therapies often have chronic adverse side effects of which cardiovascular disease is a major cause for concern. Specifically, patients ...
T-tubular remodeling occurs in a cardiomyocyte-autonomous manner following pathological mechanical stiffness exposure [0.03%]
病理性机械刚度暴露后T管重塑以心肌细胞自主方式进行
Michael Ibrahim,Vasiliki Courelli,Lan Cheng et al.
Michael Ibrahim et al.
T-tubules are invaginations of the cardiomyocyte sarcolemma, essential for excitation-contraction coupling and calcium-induced calcium release. Disruption of T-tubule structure contributes to contractile dysfunction in heart failure, yet th...
Characteristics, clinical outcomes and molecular mechanisms associated with severe diastolic dysfunction in aortic stenosis [0.03%]
主动脉瓣狭窄患者严重舒张功能障碍的特点、临床转归及分子机制
Kyriakos Panaou,Constantijn S Venema,Kees H van Bergeijk et al.
Kyriakos Panaou et al.
Objectives: We aimed to better understand patient characteristics and pathophysiological mechanisms associated with severe diastolic dysfunction in aortic stenosis patients undergoing transcatheter aortic valve implantati...
Corrigendum to "Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation" [J Mol Cell Cardiol Plus 13 (2025) 100479] [0.03%]
关于“用于虚拟疗法评估的性别特异性人类机电多尺度在硅模型”的勘误[J Mol Cell Cardiol Plus 13 (2025) 100479]
Maxx Holmes,Zhinuo Jenny Wang,Ruben Doste et al.
Maxx Holmes et al.
[This corrects the article DOI: 10.1016/j.jmccpl.2025.100479.]. © 2025 The Author(s).
Integrated heart-blood RNA editome profiling reveals circulating A-to-I editing candidates linked to dilated cardiomyopathy myocardial signatures and heart failure [0.03%]
整合的心脏-血液RNA编辑组分析揭示了与扩张型心肌病心脏特征和心力衰竭相关的新鲜血液A-to-I编辑候选者
Korina Karagianni,Mantiana Topouzi,Ilektra Mitsi et al.
Korina Karagianni et al.
Background: Dilated cardiomyopathy (DCM) is a leading cause of heart failure (HF), yet molecular signatures that are detectable in blood and mechanistically anchored in myocardial pathology remain limited. Adenosine-to-in...
Deletion of Cd248 in Postn + myofibroblast fails to attenuate pressure-overload induced cardiac remodeling and fibrosis in mice [0.03%]
Cd248在Postn+心肌纤维母细胞中的缺失未能减轻小鼠压力超负荷诱导的心脏重塑和纤维化
Donghua Li,Dongmei Zhong,Tian Tan et al.
Donghua Li et al.
Cardiac fibrosis driven by activated myofibroblasts is a central feature of pressure-overload heart disease. CD248 (Endosialin/TEM1) has been implicated as a pro-fibrotic marker in ischemic cardiac injury, but its role in pressure overload ...
RNA modifications in peripheral blood are associated with acute coronary syndrome [0.03%]
外周血的RNA修饰与急性冠脉综合征相关性研究
Miron Sopic,Victoria Stopa,Jelena Munjas et al.
Miron Sopic et al.
Acute coronary syndromes (ACS) trigger inflammatory and immune reactions, yet whether this response is associated with changes in RNA modifications remains poorly understood. We investigated global epitranscriptomic patterns in peripheral b...
Alyssa C Vadovsky,Eunji Jeong,Sandeep Banga et al.
Alyssa C Vadovsky et al.
Heart failure is chronic condition that is diagnosed when the heart is no longer able to pump enough blood to meet the physiological needs of the body. It is a progressive condition and typically manifests early on as exercise intolerance d...
Response of human iPSC-cardiomyocytes to adrenergic drugs assessed by high-throughput pericellular oxygen measurements and computational modeling [0.03%]
人诱导多能干细胞心肌细胞对肾上腺素药物的反应通过高通量细胞外氧测量和计算建模进行表征
Weizhen Li,M Amin Forouzandehmehr,David McLeod et al.
Weizhen Li et al.
Rate- and contractility-modulating drugs, such as adrenergic agonists and antagonists, are widely used in the treatment of cardiovascular conditions. Preclinical assessment of new modulators of rate, inotropy and metabolism can be aided by ...