Insulin use promotes pro-inflammatory changes in the transcriptome of atherosclerotic plaques in patients with diabetes mellitus [0.03%]
胰岛素使用促进糖尿病患者动脉粥样硬化斑块转录组的促炎变化
Angelle Bradford,Tadashi Yoshida,Sergiy Sukhanov et al.
Angelle Bradford et al.
Background: Diabetes Mellitus is associated with increased risk of myocardial infarctions and strokes due to accelerated atherosclerotic plaque development and rupture. The mechanisms driving plaque rupture in the diabeti...
Impaired PGC-1α-pAMPK signaling in postmenopausal women undergoing cardiac surgery and the role of nicotinamide in its reversal: Insights from a murine model [0.03%]
绝经后女性心脏手术中PGC-1α-pAMPK信号受损及烟酰胺逆转的机制：来自小鼠模型的启示
Mark Robitaille,Usman Ahmed,Juan Valencia et al.
Mark Robitaille et al.
Postmenopausal women undergoing cardiac surgery face disproportionately worse outcomes compared with men, a disparity linked to mitochondrial dysfunction following estrogen loss. We investigated sex-specific metabolic responses to cardiac s...
Metformin alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy [0.03%]
二甲双胍缓解实验性糖尿病心肌病小鼠的舒张功能障碍
Jordan S F Chan,Seyed Amirhossein Tabatabaei Dakhili,Nadeen R Wu et al.
Jordan S F Chan et al.
The first line therapy for managing type 2 diabetes (T2D), metformin, has been shown to be cardioprotective in humans and several preclinical models of cardiovascular disease. However, there has been limited interrogation into metformin's e...
Cardiomyocyte Rac1 signaling in hypertrophy, arrhythmia, and cardiac stress adaptation [0.03%]
心脏肥大、心律失常和心脏应激适应中的心肌细胞Rac1信号转导
James P Teuber,Rachel E Scissors,Matthew J Brody
James P Teuber
Cardiovascular disease remains the leading cause of mortality globally and is often marked by pathologic cardiac remodeling including hypertrophy and fibrosis that promote the progression to heart failure. Ras-related C3 botulinum toxin sub...
FABP3 and FABP4 promote lipid peroxidation injury during static cold storage of donor heart: Insights from multi-omics and therapeutic targeting [0.03%]
脂肪结合蛋白3和4促进供心静态冷保存过程中的脂质过氧化损伤：多组学及靶向治疗的新见解
Yu Feng,Yongbu Peng,Jincheng Hou et al.
Yu Feng et al.
Objectives: To clarify the mechanism of myocardial injury associated with lipid peroxidation and the role of fatty acid binding proteins FABP3/4 during Static cold storage (SCS) of donor hearts. ...
Cancer-driven cytokine immunomodulation ameliorates cardiac function and suppresses fibrosis [0.03%]
癌症驱动的细胞因子免疫调节改善心脏功能并抑制纤维化
Laris Achlaug,Lama Awwad,Irina Langier Goncalves et al.
Laris Achlaug et al.
Heart failure remains a leading cause of morbidity and mortality worldwide, with limited progress in the development of novel therapies. It has been demonstrated that tumor growth improves cardiac function and reduces myocardial fibrosis in...
Coxsackie and adenovirus receptor is a novel regulator of inflammatory response in endotoxin-induced failing heart [0.03%]
柯萨奇病毒和腺病毒受体是内毒素诱导的心力衰竭中炎性反应的新调控因子
Reo Matsumura,Mototsugu Nishii,Haruya Usuku et al.
Reo Matsumura et al.
The regulatory mechanisms for inflammatory response in the heart to endotoxin, which causes severe cardiac dysfunction, are not fully understood. We hypothesized the involvement of coxsackie and adenovirus receptor (CXADR), which can promot...
Rab10 plays a protective role in the development of pathological cardiac hypertrophy [0.03%]
Rab10在病理性心脏肥厚发生发展中的保护作用研究
Fang Xu,Min Wu,Yihan Wang et al.
Fang Xu et al.
Prolonged cardiac hypertrophy is a main risk factor for heart failure (HF). During cardiac hypertrophy remodelling, there is an increase in protein synthesis, as well as the trafficking and localization of proteins to their functional sites...
Signaling pathway alterations in hearts of a porcine model harboring a β-myosin heavy chain (MYH7-R403Q) gene variant [0.03%]
携带β-肌球蛋白重链(MYH7-R403Q)基因变异的猪模型心脏信号通路改变
Chad M Warren,David M Ryba,Gail E Geist et al.
Chad M Warren et al.
The disease-causing myosin variant (MYH7-403Q) is linked to hypertrophic cardiomyopathy (HCM). We carried out a research study of signaling pathways in heart samples from control wild-type (WT) GE Yucatán mini-pigs and their littermates ha...
YAP/TAZ deletion in vascular smooth muscle cells mirrors atherosclerosis-associated transcriptional programs [0.03%]
血管平滑肌细胞中YAP / TAZ的缺失可模拟动脉粥样硬化相关的转录程序
Fatima Daoud,Johan Holmberg,Hanna Winter et al.
Fatima Daoud et al.
The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeostasis. This study investigates the consequences of VSMC-specific YAP/TAZ deletion and its...